increased bone marrow cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description increased number of cells that make up the core cavities of bones when compared to the normal state (Mammalian Phenotype Ontology, MP_0000321)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000321
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Genes

39 gene mutations causing the increased bone marrow cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ASXL1 additional sex combs like transcriptional regulator 1
CCNE1 cyclin E1
CD47 CD47 molecule
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CNN2 calponin 2
CREBBP CREB binding protein
CSF3R colony stimulating factor 3 receptor (granulocyte)
DCC DCC netrin 1 receptor
DIAPH1 diaphanous-related formin 1
EGR1 early growth response 1
ESR2 estrogen receptor 2 (ER beta)
FLT3 fms-related tyrosine kinase 3
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
IRF8 interferon regulatory factor 8
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAM2 junctional adhesion molecule 2
LCN2 lipocalin 2
LIG1 ligase I, DNA, ATP-dependent
MPZL3 myelin protein zero-like 3
MYB v-myb avian myeloblastosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RBL1 retinoblastoma-like 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SAMD9L sterile alpha motif domain containing 9-like
SH2B3 SH2B adaptor protein 3
SHARPIN SHANK-associated RH domain interactor
SIPA1 signal-induced proliferation-associated 1
SMAP1 small ArfGAP 1
SPI1 Spi-1 proto-oncogene
SPP1 secreted phosphoprotein 1
SPTA1 spectrin, alpha, erythrocytic 1
TET2 tet methylcytosine dioxygenase 2
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast)
UROS uroporphyrinogen III synthase