increased body size Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description larger than average body weight, height and/or length of an organism compared to controls (Mammalian Phenotype Ontology, MP_0001264)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001264
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Genes

240 gene mutations causing the increased body size phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACADVL acyl-CoA dehydrogenase, very long chain
ACE angiotensin I converting enzyme
ADIPOQ adiponectin, C1Q and collagen domain containing
AFF4 AF4/FMR2 family, member 4
AGA aspartylglucosaminidase
AGRP agouti related neuropeptide
AHR aryl hydrocarbon receptor
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ALMS1 Alstrom syndrome protein 1
ALPI alkaline phosphatase, intestinal
ALS2 amyotrophic lateral sclerosis 2 (juvenile)
ANGPTL6 angiopoietin-like 6
ANKRD26 ankyrin repeat domain 26
ANXA7 annexin A7
AR androgen receptor
ASIP agouti signaling protein
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
ATXN2 ataxin 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5
B9D1 B9 protein domain 1
BAG3 BCL2-associated athanogene 3
BBIP1 BBSome interacting protein 1
BBS1 Bardet-Biedl syndrome 1
BBS12 Bardet-Biedl syndrome 12
BBS2 Bardet-Biedl syndrome 2
BBS4 Bardet-Biedl syndrome 4
BBS5 Bardet-Biedl syndrome 5
BCAM basal cell adhesion molecule (Lutheran blood group)
BDNF brain-derived neurotrophic factor
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
BRCA1 breast cancer 1, early onset
BRD2 bromodomain containing 2
BRS3 bombesin-like receptor 3
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CARTPT CART prepropeptide
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX7 chromobox homolog 7
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CELF4 CUGBP, Elav-like family member 4
CEP19 centrosomal protein 19kDa
CER1 cerberus 1, DAN family BMP antagonist
CINP cyclin-dependent kinase 2 interacting protein
CLOCK clock circadian regulator
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
CORIN corin, serine peptidase
CPE carboxypeptidase E
CRH corticotropin releasing hormone
CRTC1 CREB regulated transcription coactivator 1
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSMD1 CUB and Sushi multiple domains 1
CSPG4 chondroitin sulfate proteoglycan 4
CTF1 cardiotrophin 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DDO D-aspartate oxidase
DIO1 deiodinase, iodothyronine, type I
DLL1 delta-like 1 (Drosophila)
DMXL2 Dmx-like 2
DNM1L dynamin 1-like
DRD2 dopamine receptor D2
DRG2 developmentally regulated GTP binding protein 2
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EYA3 EYA transcriptional coactivator and phosphatase 3
FAS Fas cell surface death receptor
FEN1 flap structure-specific endonuclease 1
FFAR2 free fatty acid receptor 2
FGF21 fibroblast growth factor 21
FGL1 fibrinogen-like 1
FMR1 fragile X mental retardation 1
FSHR follicle stimulating hormone receptor
GCG glucagon
GCK glucokinase (hexokinase 4)
GDF15 growth differentiation factor 15
GHR growth hormone receptor
GHRHR growth hormone releasing hormone receptor
GNAS GNAS complex locus
GNRHR gonadotropin-releasing hormone receptor
GPC3 glypican 3
GPR12 G protein-coupled receptor 12
GPR39 G protein-coupled receptor 39
GRB10 growth factor receptor-bound protein 10
GRM8 glutamate receptor, metabotropic 8
GSTP1 glutathione S-transferase pi 1
GUCY2C guanylate cyclase 2C
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HDAC6 histone deacetylase 6
HDC histidine decarboxylase
HFE hemochromatosis
HNF4G hepatocyte nuclear factor 4, gamma
HOXC10 homeobox C10
HPRT1 hypoxanthine phosphoribosyltransferase 1
HRH1 histamine receptor H1
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
IDUA iduronidase, alpha-L-
IGF2R insulin-like growth factor 2 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL1R1 interleukin 1 receptor, type I
IL5 interleukin 5
IL6 interleukin 6
INHBA inhibin, beta A
IRS2 insulin receptor substrate 2
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KDM3A lysine (K)-specific demethylase 3A
KLF6 Kruppel-like factor 6
KLHDC2 kelch domain containing 2
KPTN kaptin (actin binding protein)
KRT7 keratin 7, type II
KSR2 kinase suppressor of ras 2
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LHCGR luteinizing hormone/choriogonadotropin receptor
LIN9 lin-9 DREAM MuvB core complex component
LPL lipoprotein lipase
LTA lymphotoxin alpha
MARVELD2 MARVEL domain containing 2
MC3R melanocortin 3 receptor
MC4R melanocortin 4 receptor
MECP2 methyl CpG binding protein 2
MEP1B meprin A, beta
MKKS McKusick-Kaufman syndrome
MMP9 matrix metallopeptidase 9
MRAP2 melanocortin 2 receptor accessory protein 2
MSTN myostatin
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MTUS1 microtubule associated tumor suppressor 1
NCOA1 nuclear receptor coactivator 1
NCOA3 nuclear receptor coactivator 3
NEIL1 nei endonuclease VIII-like 1 (E. coli)
NGFR nerve growth factor receptor
NHLH2 nescient helix loop helix 2
NMU neuromedin U
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPB neuropeptide B
NPR3 natriuretic peptide receptor 3
NPY1R neuropeptide Y receptor Y1
NPY2R neuropeptide Y receptor Y2
NPY5R neuropeptide Y receptor Y5
NTSR1 neurotensin receptor 1 (high affinity)
NUAK2 NUAK family, SNF1-like kinase, 2
OCA2 oculocutaneous albinism II
OMA1 OMA1 zinc metallopeptidase
OPRM1 opioid receptor, mu 1
PANK1 pantothenate kinase 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE3B phosphodiesterase 3B, cGMP-inhibited
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEG3 paternally expressed 3
PER2 period circadian clock 2
PEX11A peroxisomal biogenesis factor 11 alpha
PITX3 paired-like homeodomain 3
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
PLSCR3 phospholipid scramblase 3
PNPLA2 patatin-like phospholipase domain containing 2
POMC proopiomelanocortin
PPARA peroxisome proliferator-activated receptor alpha
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PREP prolyl endopeptidase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PRLH prolactin releasing hormone
PRLHR prolactin releasing hormone receptor
PTCH1 patched 1
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN3 protein tyrosine phosphatase, non-receptor type 3
PYY peptide YY
RAI1 retinoic acid induced 1
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RB1 retinoblastoma 1
RDH16 retinol dehydrogenase 16 (all-trans)
RNF10 ring finger protein 10
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RSBN1 round spermatid basic protein 1
RSC1A1 regulatory solute carrier protein, family 1, member 1
RYR1 ryanodine receptor 1 (skeletal)
SCIMP SLP adaptor and CSK interacting membrane protein
SELM selenoprotein M
SERF1A small EDRK-rich factor 1A (telomeric)
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SHANK3 SH3 and multiple ankyrin repeat domains 3
SIM1 single-minded family bHLH transcription factor 1
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SMAD3 SMAD family member 3
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNAP47 synaptosomal-associated protein, 47kDa
SNRPN small nuclear ribonucleoprotein polypeptide N
SOCS2 suppressor of cytokine signaling 2
SOST sclerostin
SPRN shadow of prion protein homolog (zebrafish)
SPTBN1 spectrin, beta, non-erythrocytic 1
SPTBN2 spectrin, beta, non-erythrocytic 2
SQSTM1 sequestosome 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5B signal transducer and activator of transcription 5B
STC2 stanniocalcin 2
TACR3 tachykinin receptor 3
TERF2IP telomeric repeat binding factor 2, interacting protein
TGM2 transglutaminase 2
THBS3 thrombospondin 3
THRA thyroid hormone receptor, alpha
TLR5 toll-like receptor 5
TNF tumor necrosis factor
TRIM32 tripartite motif containing 32
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSFM Ts translation elongation factor, mitochondrial
TTC39B tetratricopeptide repeat domain 39B
TTC8 tetratricopeptide repeat domain 8
TUB tubby bipartite transcription factor
TXNDC2 thioredoxin domain containing 2 (spermatozoa)
TYK2 tyrosine kinase 2
UBE3A ubiquitin protein ligase E3A
VIM vimentin
WBP5 WW domain binding protein 5
WDTC1 WD and tetratricopeptide repeats 1
XYLB xylulokinase homolog (H. influenzae)
ZC3H4 zinc finger CCCH-type containing 4
ZEB1 zinc finger E-box binding homeobox 1
ZMIZ2 zinc finger, MIZ-type containing 2