increased b cell proliferation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than normal expansion rate of the B cell population by cell division in response to stimuli (Mammalian Phenotype Ontology, MP_0005154)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005154
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Genes

56 gene mutations causing the increased b cell proliferation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL3 B-cell CLL/lymphoma 3
BIRC3 baculoviral IAP repeat containing 3
BTLA B and T lymphocyte associated
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CD22 CD22 molecule
CD300C CD300c molecule
CD72 CD72 molecule
CD81 CD81 molecule
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DTX1 deltex 1, E3 ubiquitin ligase
ELF4 E74-like factor 4 (ets domain transcription factor)
FASLG Fas ligand (TNF superfamily, member 6)
GABPB2 GA binding protein transcription factor, beta subunit 2
GAPT GRB2-binding adaptor protein, transmembrane
GPR132 G protein-coupled receptor 132
IGHM immunoglobulin heavy constant mu
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL2 interleukin 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LYN LYN proto-oncogene, Src family tyrosine kinase
MARK2 MAP/microtubule affinity-regulating kinase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA3 nuclear receptor coactivator 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OTUD7B OTU deubiquitinase 7B
PARP14 poly (ADP-ribose) polymerase family, member 14
PAWR PRKC, apoptosis, WT1, regulator
PDCD1 programmed cell death 1
PKN1 protein kinase N1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLCL2 phospholipase C-like 2
POU2AF1 POU class 2 associating factor 1
PPARG peroxisome proliferator-activated receptor gamma
PRKCD protein kinase C, delta
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RHOG ras homolog family member G
S1PR2 sphingosine-1-phosphate receptor 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SFN stratifin
SIAE sialic acid acetylesterase
SLPI secretory leukocyte peptidase inhibitor
SPTA1 spectrin, alpha, erythrocytic 1
SYK spleen tyrosine kinase
TANK TRAF family member-associated NFKB activator
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNIP1 TNFAIP3 interacting protein 1
TYROBP TYRO protein tyrosine kinase binding protein
UNC93B1 unc-93 homolog B1 (C. elegans)
WIPF1 WAS/WASL interacting protein family, member 1