increased b cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than normal number of cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells; these cells are involved in humoral immunity (Mammalian Phenotype Ontology, MP_0005014)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005014
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Genes

178 gene mutations causing the increased b cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AICDA activation-induced cytidine deaminase
AIRE autoimmune regulator
AKAP13 A kinase (PRKA) anchor protein 13
APOE apolipoprotein E
AR androgen receptor
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
AVPR1A arginine vasopressin receptor 1A
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BANK1 B-cell scaffold protein with ankyrin repeats 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL3 B-cell CLL/lymphoma 3
BCLAF1 BCL2-associated transcription factor 1
BIRC3 baculoviral IAP repeat containing 3
BLNK B-cell linker
BMF Bcl2 modifying factor
BST1 bone marrow stromal cell antigen 1
BTK Bruton agammaglobulinemia tyrosine kinase
C1ORF198 chromosome 1 open reading frame 198
CCR2 chemokine (C-C motif) receptor 2
CCR6 chemokine (C-C motif) receptor 6
CD22 CD22 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD69 CD69 molecule
CD72 CD72 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD79A CD79a molecule, immunoglobulin-associated alpha
CD79B CD79b molecule, immunoglobulin-associated beta
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CYLD cylindromatosis (turban tumor syndrome)
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGKZ diacylglycerol kinase, zeta
DLK1 delta-like 1 homolog (Drosophila)
DLL1 delta-like 1 (Drosophila)
ELF4 E74-like factor 4 (ets domain transcription factor)
EPS15 epidermal growth factor receptor pathway substrate 15
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBN1 fibrillin 1
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCMR Fc fragment of IgM receptor
FES FES proto-oncogene, tyrosine kinase
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FOXN1 forkhead box N1
FSHR follicle stimulating hormone receptor
GAPT GRB2-binding adaptor protein, transmembrane
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
HAX1 HCLS1 associated protein X-1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ICOS inducible T-cell co-stimulator
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
IL6ST interleukin 6 signal transducer
IRF8 interferon regulatory factor 8
ITFG2 integrin alpha FG-GAP repeat containing 2
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITK IL2-inducible T-cell kinase
JAK1 Janus kinase 1
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLHL6 kelch-like family member 6
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LCN2 lipocalin 2
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LTA lymphotoxin alpha
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LYN LYN proto-oncogene, Src family tyrosine kinase
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MCPH1 microcephalin 1
MED18 mediator complex subunit 18
MIR150 microRNA 150
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1G myosin IG
NCOA3 nuclear receptor coactivator 3
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRP6 NLR family, pyrin domain containing 6
NR1D2 nuclear receptor subfamily 1, group D, member 2
OTUD7B OTU deubiquitinase 7B
PARP14 poly (ADP-ribose) polymerase family, member 14
PDCD1 programmed cell death 1
PEX3 peroxisomal biogenesis factor 3
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PKN1 protein kinase N1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PNP purine nucleoside phosphorylase
POLB polymerase (DNA directed), beta
PRKCD protein kinase C, delta
PRKCH protein kinase C, eta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRJ protein tyrosine phosphatase, receptor type, J
RAG1 recombination activating gene 1
RAG2 recombination activating gene 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RGS1 regulator of G-protein signaling 1
RGS13 regulator of G-protein signaling 13
RGS3 regulator of G-protein signaling 3
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
S1PR2 sphingosine-1-phosphate receptor 2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCARF1 scavenger receptor class F, member 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SEPT8 septin 8
SH2B2 SH2B adaptor protein 2
SH2B3 SH2B adaptor protein 3
SH2D1A SH2 domain containing 1A
SH3BP2 SH3-domain binding protein 2
SIAE sialic acid acetylesterase
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIGLEC10 sialic acid binding Ig-like lectin 10
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SPI1 Spi-1 proto-oncogene
SPTA1 spectrin, alpha, erythrocytic 1
SSBP2 single-stranded DNA binding protein 2
TANK TRAF family member-associated NFKB activator
TCF3 transcription factor 3
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TET2 tet methylcytosine dioxygenase 2
TGFBI transforming growth factor, beta-induced, 68kDa
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TMEM189 transmembrane protein 189
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP8L2 tumor necrosis factor, alpha-induced protein 8-like 2
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNIP1 TNFAIP3 interacting protein 1
TOM1L2 target of myb1-like 2 (chicken)
TRAF3IP2 TRAF3 interacting protein 2
TYROBP TYRO protein tyrosine kinase binding protein
UNC93B1 unc-93 homolog B1 (C. elegans)
URI1 URI1, prefoldin-like chaperone
VAV1 vav 1 guanine nucleotide exchange factor
VCAM1 vascular cell adhesion molecule 1
VPREB1 pre-B lymphocyte 1
WAS Wiskott-Aldrich syndrome
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZBTB1 zinc finger and BTB domain containing 1
ZC3H12A zinc finger CCCH-type containing 12A
ZNF318 zinc finger protein 318