increased autoantibody level Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease (Mammalian Phenotype Ontology, MP_0003725)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003725
Similar Terms
Downloads & Tools

Genes

91 gene mutations causing the increased autoantibody level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
AIRE autoimmune regulator
APCS amyloid P component, serum
APOE apolipoprotein E
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BHLHE40 basic helix-loop-helix family, member e40
BLNK B-cell linker
C1QA complement component 1, q subcomponent, A chain
C4A complement component 4A (Rodgers blood group)
CD1D CD1d molecule
CD22 CD22 molecule
CD276 CD276 molecule
CD72 CD72 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CR2 complement component (3d/Epstein Barr virus) receptor 2
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DNASE1 deoxyribonuclease I
DTX1 deltex 1, E3 ubiquitin ligase
E2F2 E2F transcription factor 2
ESR1 estrogen receptor 1
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBN1 fibrillin 1
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCMR Fc fragment of IgM receptor
FCRLB Fc receptor-like B
FOXP3 forkhead box P3
GADD45A growth arrest and DNA-damage-inducible, alpha
GPR132 G protein-coupled receptor 132
GPX7 glutathione peroxidase 7
HAVCR1 hepatitis A virus cellular receptor 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10RA interleukin 10 receptor, alpha
IL12RB2 interleukin 12 receptor, beta 2
IL2RB interleukin 2 receptor, beta
IL6ST interleukin 6 signal transducer
INS insulin
JAK1 Janus kinase 1
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LIG4 ligase IV, DNA, ATP-dependent
LYN LYN proto-oncogene, Src family tyrosine kinase
MIR210 microRNA 210
MTA2 metastasis associated 1 family, member 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRP3 NLR family, pyrin domain containing 3
PDCD1 programmed cell death 1
PGAP3 post-GPI attachment to proteins 3
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PKN1 protein kinase N1
PLCL2 phospholipase C-like 2
POLB polymerase (DNA directed), beta
PRKCD protein kinase C, delta
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF5 Ras association (RalGDS/AF-6) domain family member 5
RC3H1 ring finger and CCCH-type domains 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SCARA5 scavenger receptor class A, member 5
SCARF1 scavenger receptor class F, member 1
SIAE sialic acid acetylesterase
SIRT1 sirtuin 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYK spleen tyrosine kinase
SYT7 synaptotagmin VII
TANK TRAF family member-associated NFKB activator
TBC1D10C TBC1 domain family, member 10C
THBS1 thrombospondin 1
TIMD4 T-cell immunoglobulin and mucin domain containing 4
TLR8 toll-like receptor 8
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TNIP1 TNFAIP3 interacting protein 1
TRAF3IP2 TRAF3 interacting protein 2
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21
TROVE2 TROVE domain family, member 2
TUSC2 tumor suppressor candidate 2
TYROBP TYRO protein tyrosine kinase binding protein
UNC93B1 unc-93 homolog B1 (C. elegans)
WAS Wiskott-Aldrich syndrome
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZC3H12A zinc finger CCCH-type containing 12A