increased alpha-beta t cell number Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater number of T cells that expresses an alpha-beta T cell receptor complex (Mammalian Phenotype Ontology, MP_0012764)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0012764
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Genes

157 gene mutations causing the increased alpha-beta t cell number phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR4 atypical chemokine receptor 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADRM1 adhesion regulating molecule 1
AKAP9 A kinase (PRKA) anchor protein 9
ANPEP alanyl (membrane) aminopeptidase
APOE apolipoprotein E
ARL4D ADP-ribosylation factor-like 4D
B2M beta-2-microglobulin
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BBC3 BCL2 binding component 3
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BHLHE40 basic helix-loop-helix family, member e40
BLNK B-cell linker
BMF Bcl2 modifying factor
BTK Bruton agammaglobulinemia tyrosine kinase
C17ORF62 chromosome 17 open reading frame 62
CARD11 caspase recruitment domain family, member 11
CBFB core-binding factor, beta subunit
CCL13 chemokine (C-C motif) ligand 13
CCR2 chemokine (C-C motif) receptor 2
CCR4 chemokine (C-C motif) receptor 4
CCR7 chemokine (C-C motif) receptor 7
CD19 CD19 molecule
CD274 CD274 molecule
CD4 CD4 molecule
CD40LG CD40 ligand
CD48 CD48 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD8A CD8a molecule
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CDK6 cyclin-dependent kinase 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CENPJ centromere protein J
CHD2 chromodomain helicase DNA binding protein 2
CHD7 chromodomain helicase DNA binding protein 7
CIITA class II, major histocompatibility complex, transactivator
CLEC4G C-type lectin domain family 4, member G
COL10A1 collagen, type X, alpha 1
CRTAM cytotoxic and regulatory T cell molecule
CTSV cathepsin V
CXCR2 chemokine (C-X-C motif) receptor 2
DCK deoxycytidine kinase
DLL1 delta-like 1 (Drosophila)
DUSP4 dual specificity phosphatase 4
E2F1 E2F transcription factor 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FAM83G family with sequence similarity 83, member G
FBXO7 F-box protein 7
FOXP2 forkhead box P2
FOXP3 forkhead box P3
GPR15 G protein-coupled receptor 15
GRAP GRB2-related adaptor protein
HAVCR1 hepatitis A virus cellular receptor 1
HELLS helicase, lymphoid-specific
HLA-A major histocompatibility complex, class I, A
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGN5 high mobility group nucleosome binding domain 5
HP1BP3 heterochromatin protein 1, binding protein 3
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFNG interferon, gamma
IL10 interleukin 10
IL13RA1 interleukin 13 receptor, alpha 1
IL15RA interleukin 15 receptor, alpha
IL17RA interleukin 17 receptor A
IL2 interleukin 2
IL2RB interleukin 2 receptor, beta
IL6ST interleukin 6 signal transducer
IL9R interleukin 9 receptor
IRF1 interferon regulatory factor 1
ITGAD integrin, alpha D
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITK IL2-inducible T-cell kinase
JAK3 Janus kinase 3
LAG3 lymphocyte-activation gene 3
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAT linker for activation of T cells
LGALS9B lectin, galactoside-binding, soluble, 9B
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MIR155 microRNA 155
MMP9 matrix metallopeptidase 9
MPG N-methylpurine-DNA glycosylase
MPZL2 myelin protein zero-like 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYSM1 Myb-like, SWIRM and MPN domains 1
NCOA3 nuclear receptor coactivator 3
NDFIP1 Nedd4 family interacting protein 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NLRP3 NLR family, pyrin domain containing 3
NOD2 nucleotide-binding oligomerization domain containing 2
NPY1R neuropeptide Y receptor Y1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PITX3 paired-like homeodomain 3
PLA2G2D phospholipase A2, group IID
PNP purine nucleoside phosphorylase
POLB polymerase (DNA directed), beta
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP5C protein phosphatase 5, catalytic subunit
PRKCH protein kinase C, eta
PRMT3 protein arginine methyltransferase 3
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RC3H1 ring finger and CCCH-type domains 1
REG3G regenerating islet-derived 3 gamma
RGS3 regulator of G-protein signaling 3
RRAS related RAS viral (r-ras) oncogene homolog
RUNX1 runt-related transcription factor 1
S1PR1 sphingosine-1-phosphate receptor 1
SCARF1 scavenger receptor class F, member 1
SETD1A SET domain containing 1A
SETDB1 SET domain, bifurcated 1
SGMS1 sphingomyelin synthase 1
SGPL1 sphingosine-1-phosphate lyase 1
SH2D1A SH2 domain containing 1A
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SLC39A3 solute carrier family 39 (zinc transporter), member 3
SPNS2 spinster homolog 2 (Drosophila)
SPTA1 spectrin, alpha, erythrocytic 1
STK17B serine/threonine kinase 17b
SYK spleen tyrosine kinase
SYTL1 synaptotagmin-like 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX21 T-box 21
TCF12 transcription factor 12
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1
TMEM127 transmembrane protein 127
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNIP1 TNFAIP3 interacting protein 1
TOM1L2 target of myb1-like 2 (chicken)
TRIB2 tribbles pseudokinase 2
UNC13D unc-13 homolog D (C. elegans)
UNC93B1 unc-93 homolog B1 (C. elegans)
USP42 ubiquitin specific peptidase 42
VTCN1 V-set domain containing T cell activation inhibitor 1
WDTC1 WD and tetratricopeptide repeats 1
ZBTB7B zinc finger and BTB domain containing 7B
ZC3H12D zinc finger CCCH-type containing 12D
ZNF175 zinc finger protein 175