increased alimentary system tumor incidence Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description greater than the expected number of tumors originating in the alimentary system in a given population in a given time period (Mammalian Phenotype Ontology, MP_0010292)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0010292
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Genes

56 gene mutations causing the increased alimentary system tumor incidence phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
APC adenomatous polyposis coli
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX2 caudal type homeobox 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DCC DCC netrin 1 receptor
GAST gastrin
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GON4L gon-4-like (C. elegans)
GPX7 glutathione peroxidase 7
HELQ helicase, POLQ-like
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IL10 interleukin 10
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LIG4 ligase IV, DNA, ATP-dependent
LTBP4 latent transforming growth factor beta binding protein 4
LZTS1 leucine zipper, putative tumor suppressor 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MLH1 mutL homolog 1
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MUC2 mucin 2, oligomeric mucus/gel-forming
NFE2L2 nuclear factor, erythroid 2-like 2
NLRP6 NLR family, pyrin domain containing 6
NUAK2 NUAK family, SNF1-like kinase, 2
NUDT1 nudix (nucleoside diphosphate linked moiety X)-type motif 1
PAX6 paired box 6
PER2 period circadian clock 2
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
PPARD peroxisome proliferator-activated receptor delta
PTCH1 patched 1
PTEN phosphatase and tensin homolog
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
SGOL1 shugoshin-like 1 (S. pombe)
SIRT2 sirtuin 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SSBP2 single-stranded DNA binding protein 2
STK11 serine/threonine kinase 11
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TES testin LIM domain protein
TFF1 trefoil factor 1
TGFB1 transforming growth factor, beta 1
TLR2 toll-like receptor 2
TNK1 tyrosine kinase, non-receptor, 1
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated