improved glucose tolerance Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals (Mammalian Phenotype Ontology, MP_0005292)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005292
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Genes

142 gene mutations causing the improved glucose tolerance phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
ACOT11 acyl-CoA thioesterase 11
ACOT13 acyl-CoA thioesterase 13
ACTB actin, beta
ADGRF5 adhesion G protein-coupled receptor F5
ADIPOR2 adiponectin receptor 2
AHSG alpha-2-HS-glycoprotein
AKAP5 A kinase (PRKA) anchor protein 5
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANGPTL2 angiopoietin-like 2
APOE apolipoprotein E
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ATF4 activating transcription factor 4
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BCAT2 branched chain amino-acid transaminase 2, mitochondrial
BRD2 bromodomain containing 2
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL13 chemokine (C-C motif) ligand 13
CDH23 cadherin-related 23
CERS6 ceramide synthase 6
CES1 carboxylesterase 1
CHRM3 cholinergic receptor, muscarinic 3
CIDEC cell death-inducing DFFA-like effector c
CNOT3 CCR4-NOT transcription complex, subunit 3
COL1A1 collagen, type I, alpha 1
COL4A5 collagen, type IV, alpha 5
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung)
CRBN cereblon
CREBBP CREB binding protein
CSMD1 CUB and Sushi multiple domains 1
CXCL14 chemokine (C-X-C motif) ligand 14
DBN1 drebrin 1
DGAT1 diacylglycerol O-acyltransferase 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DPP4 dipeptidyl-peptidase 4
EMC10 ER membrane protein complex subunit 10
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EPM2AIP1 EPM2A (laforin) interacting protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FFAR1 free fatty acid receptor 1
FGF23 fibroblast growth factor 23
FSTL3 follistatin-like 3 (secreted glycoprotein)
FTO fat mass and obesity associated
G0S2 G0/G1 switch 2
GAST gastrin
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCG glucagon
GCGR glucagon receptor
GDF3 growth differentiation factor 3
GHRL ghrelin/obestatin prepropeptide
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAS GNAS complex locus
GPR21 G protein-coupled receptor 21
GRB14 growth factor receptor-bound protein 14
GSK3A glycogen synthase kinase 3 alpha
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IAPP islet amyloid polypeptide
IL10RB interleukin 10 receptor, beta
INPP5K inositol polyphosphate-5-phosphatase K
INPPL1 inositol polyphosphate phosphatase-like 1
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KL klotho
KLF15 Kruppel-like factor 15
LDHA lactate dehydrogenase A
LEPR leptin receptor
LGALS12 lectin, galactoside-binding, soluble, 12
LRP6 low density lipoprotein receptor-related protein 6
LRRN3 leucine rich repeat neuronal 3
MAPK13 mitogen-activated protein kinase 13
MAPK8 mitogen-activated protein kinase 8
MAPKBP1 mitogen-activated protein kinase binding protein 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MBD5 methyl-CpG binding domain protein 5
MBOAT4 membrane bound O-acyltransferase domain containing 4
MGLL monoglyceride lipase
MIR184 microRNA 184
MOGAT2 monoacylglycerol O-acyltransferase 2
MSTN myostatin
MYO7A myosin VIIA
NCOA3 nuclear receptor coactivator 3
NLN neurolysin (metallopeptidase M3 family)
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
OPRM1 opioid receptor, mu 1
PASK PAS domain containing serine/threonine kinase
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PGR progesterone receptor
PHOX2A paired-like homeobox 2a
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G1B phospholipase A2, group IB (pancreas)
PNPLA2 patatin-like phospholipase domain containing 2
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L
PPP1R3B protein phosphatase 1, regulatory subunit 3B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCD protein kinase C, delta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RCAN2 regulator of calcineurin 2
RETN resistin
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCN3A sodium channel, voltage gated, type III alpha subunit
SDC3 syndecan 3
SERTAD2 SERTA domain containing 2
SGMS2 sphingomyelin synthase 2
SIK3 SIK family kinase 3
SLC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SOCS3 suppressor of cytokine signaling 3
SOCS7 suppressor of cytokine signaling 7
SORBS1 sorbin and SH3 domain containing 1
SPP1 secreted phosphoprotein 1
SRA1 steroid receptor RNA activator 1
SSFA2 sperm specific antigen 2
SSTR5 somatostatin receptor 5
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STRA6 stimulated by retinoic acid 6
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFB1 transforming growth factor, beta 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TXNIP thioredoxin interacting protein
UBE3B ubiquitin protein ligase E3B
UCN3 urocortin 3
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
USH1C Usher syndrome 1C (autosomal recessive, severe)
USP22 ubiquitin specific peptidase 22
ZBTB20 zinc finger and BTB domain containing 20