impaired glucose tolerance Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0005293
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Genes

196 gene mutations causing the impaired glucose tolerance phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACADVL acyl-CoA dehydrogenase, very long chain
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADRA1B adrenoceptor alpha 1B
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALX3 ALX homeobox 3
APOE apolipoprotein E
ASIP agouti signaling protein
ATG3 autophagy related 3
BAD BCL2-associated agonist of cell death
BBS5 Bardet-Biedl syndrome 5
BGLAP bone gamma-carboxyglutamate (gla) protein
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit
CADPS2 Ca++-dependent secretion activator 2
CARTPT CART prepropeptide
CCDC80 coiled-coil domain containing 80
CCL13 chemokine (C-C motif) ligand 13
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD38 CD38 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPJ centromere protein J
CEP19 centrosomal protein 19kDa
CHGB chromogranin B
CISD2 CDGSH iron sulfur domain 2
CLOCK clock circadian regulator
COL4A5 collagen, type IV, alpha 5
COL5A3 collagen, type V, alpha 3
CPE carboxypeptidase E
CREBBP CREB binding protein
CRH corticotropin releasing hormone
CRTC1 CREB regulated transcription coactivator 1
CSPG4 chondroitin sulfate proteoglycan 4
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5R4 cytochrome b5 reductase 4
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
E2F1 E2F transcription factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
ERO1LB ERO1-like beta (S. cerevisiae)
ESR1 estrogen receptor 1
FAM3B family with sequence similarity 3, member B
FEM1B fem-1 homolog b (C. elegans)
FFAR2 free fatty acid receptor 2
FFAR3 free fatty acid receptor 3
FFAR4 free fatty acid receptor 4
FGF21 fibroblast growth factor 21
FGL1 fibrinogen-like 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXA1 forkhead box A1
FOXO3 forkhead box O3
GCK glucokinase (hexokinase 4)
GCKR glucokinase (hexokinase 4) regulator
GEM GTP binding protein overexpressed in skeletal muscle
GIPR gastric inhibitory polypeptide receptor
GLIS3 GLIS family zinc finger 3
GLP1R glucagon-like peptide 1 receptor
GNAS GNAS complex locus
GPBAR1 G protein-coupled bile acid receptor 1
GPER1 G protein-coupled estrogen receptor 1
GPR26 G protein-coupled receptor 26
GSTA4 glutathione S-transferase alpha 4
GUCY2C guanylate cyclase 2C
GYS2 glycogen synthase 2 (liver)
HDC histidine decarboxylase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIPK3 homeodomain interacting protein kinase 3
HMGA1 high mobility group AT-hook 1
HMGN3 high mobility group nucleosomal binding domain 3
HNF4A hepatocyte nuclear factor 4, alpha
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IDE insulin-degrading enzyme
IFT88 intraflagellar transport 88
IGFBP4 insulin-like growth factor binding protein 4
IL10RB interleukin 10 receptor, beta
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
ILDR2 immunoglobulin-like domain containing receptor 2
INS insulin
INSL5 insulin-like 5
INSR insulin receptor
IP6K1 inositol hexakisphosphate kinase 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
KMT2B lysine (K)-specific methyltransferase 2B
KPTN kaptin (actin binding protein)
LCMT1 leucine carboxyl methyltransferase 1
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LPIN1 lipin 1
LRP5 low density lipoprotein receptor-related protein 5
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
MAPKBP1 mitogen-activated protein kinase binding protein 1
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MRAP2 melanocortin 2 receptor accessory protein 2
MRPS5 mitochondrial ribosomal protein S5
MTMR3 myotubularin related protein 3
NAMPT nicotinamide phosphoribosyltransferase
NCOA3 nuclear receptor coactivator 3
NCOA5 nuclear receptor coactivator 5
NEUROG3 neurogenin 3
NKIRAS2 NFKB inhibitor interacting Ras-like 2
NNT nicotinamide nucleotide transhydrogenase
NPY1R neuropeptide Y receptor Y1
NPY6R neuropeptide Y receptor Y6 (pseudogene)
NR1H4 nuclear receptor subfamily 1, group H, member 4
OMA1 OMA1 zinc metallopeptidase
ONECUT1 one cut homeobox 1
OSMR oncostatin M receptor
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PAM peptidylglycine alpha-amidating monooxygenase
PAX6 paired box 6
PBX1 pre-B-cell leukemia homeobox 1
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCSK2 proprotein convertase subtilisin/kexin type 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PDX1 pancreatic and duodenal homeobox 1
PFKM phosphofructokinase, muscle
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLIN1 perilipin 1
PLSCR3 phospholipid scramblase 3
POMC proopiomelanocortin
PPARG peroxisome proliferator-activated receptor gamma
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PRKCD protein kinase C, delta
PRKCI protein kinase C, iota
PRLH prolactin releasing hormone
PRLR prolactin receptor
PTPRN protein tyrosine phosphatase, receptor type, N
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTRF polymerase I and transcript release factor
PYY peptide YY
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RBM4 RNA binding motif protein 4
RBM4B RNA binding motif protein 4B
REG3A regenerating islet-derived 3 alpha
RGPD1 RANBP2-like and GRIP domain containing 1
RGS10 regulator of G-protein signaling 10
RGS7 regulator of G-protein signaling 7
RIMS2 regulating synaptic membrane exocytosis 2
RPH3AL rabphilin 3A-like (without C2 domains)
RPS6 ribosomal protein S6
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SEC16B SEC16 homolog B (S. cerevisiae)
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SERP1 stress-associated endoplasmic reticulum protein 1
SERTAD1 SERTA domain containing 1
SESN2 sestrin 2
SGMS1 sphingomyelin synthase 1
SH2B1 SH2B adaptor protein 1
SIDT2 SID1 transmembrane family, member 2
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC30A8 solute carrier family 30 (zinc transporter), member 8
SLX4 SLX4 structure-specific endonuclease subunit
SOCS2 suppressor of cytokine signaling 2
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
STEAP4 STEAP family member 4
STX4 syntaxin 4
STXBP3 syntaxin binding protein 3
TBC1D4 TBC1 domain family, member 4
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TERF2IP telomeric repeat binding factor 2, interacting protein
TGM2 transglutaminase 2
THRA thyroid hormone receptor, alpha
TRIB1 tribbles pseudokinase 1
TYK2 tyrosine kinase 2
UNC13A unc-13 homolog A (C. elegans)
USP22 ubiquitin specific peptidase 22
VIPR1 vasoactive intestinal peptide receptor 1
WFS1 Wolfram syndrome 1 (wolframin)
ZEB1 zinc finger E-box binding homeobox 1