impaired behavioral response to addictive substance Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response (Mammalian Phenotype Ontology, MP_0009750)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0009750
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Genes

42 gene mutations causing the impaired behavioral response to addictive substance phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ADORA2A adenosine A2a receptor
ADRA1B adrenoceptor alpha 1B
ADRA1D adrenoceptor alpha 1D
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
AQP4 aquaporin 4
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CCKBR cholecystokinin B receptor
CD81 CD81 molecule
CHRM5 cholinergic receptor, muscarinic 5
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CNR1 cannabinoid receptor 1 (brain)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DLG4 discs, large homolog 4 (Drosophila)
DRD1 dopamine receptor D1
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
GRM5 glutamate receptor, metabotropic 5
HIPK2 homeodomain interacting protein kinase 2
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
LRRK2 leucine-rich repeat kinase 2
NPY1R neuropeptide Y receptor Y1
OPRK1 opioid receptor, kappa 1
OPRL1 opiate receptor-like 1
OPRM1 opioid receptor, mu 1
PDLIM5 PDZ and LIM domain 5
PLAT plasminogen activator, tissue
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PRKCG protein kinase C, gamma
RGS4 regulator of G-protein signaling 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
TACR1 tachykinin receptor 1
TAOK2 TAO kinase 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
WFS1 Wolfram syndrome 1 (wolframin)