immunological synapse Gene Set

Dataset GO Cellular Component Annotations
Category structural or functional annotations
Type cellular component
Description An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. (Gene Ontology, GO_0001772)
External Link http://amigo.geneontology.org/amigo/term/GO:0001772
Similar Terms
Downloads & Tools

Genes

30 proteins localized to the immunological synapse cellular component from the curated GO Cellular Component Annotations dataset.

Symbol Name
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
BCL10 B-cell CLL/lymphoma 10
CARD11 caspase recruitment domain family, member 11
CD28 CD28 molecule
CD37 CD37 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD53 CD53 molecule
CD81 CD81 molecule
CORO1A coronin, actin binding protein, 1A
DLG1 discs, large homolog 1 (Drosophila)
DUSP3 dual specificity phosphatase 3
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
ICAM1 intercellular adhesion molecule 1
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS3 lectin, galactoside-binding, soluble, 3
MYH9 myosin, heavy chain 9, non-muscle
PDCD6IP programmed cell death 6 interacting protein
PRKCQ protein kinase C, theta
PTPRJ protein tyrosine phosphatase, receptor type, J
RHOH ras homolog family member H
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
SCIMP SLP adaptor and CSK interacting membrane protein
SNX27 sorting nexin family member 27
SOCS6 suppressor of cytokine signaling 6
STOML2 stomatin (EPB72)-like 2
STX7 syntaxin 7
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa