immunological synapse Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. (Gene Ontology, GO_0001772)
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Genes

184 proteins co-occuring with the immunological synapse cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
LCK LCK proto-oncogene, Src family tyrosine kinase 1.70014
CD4 CD4 molecule 1.65753
VAV1 vav 1 guanine nucleotide exchange factor 1.60593
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 1.39963
CTLA4 cytotoxic T-lymphocyte-associated protein 4 1.38516
ICAM1 intercellular adhesion molecule 1 1.37188
PRF1 perforin 1 (pore forming protein) 1.30336
STX11 syntaxin 11 1.23766
CD6 CD6 molecule 1.21531
FYB FYN binding protein 1.17311
CD69 CD69 molecule 1.14699
ALCAM activated leukocyte cell adhesion molecule 1.14546
CD247 CD247 molecule 1.12858
LAT linker for activation of T cells 1.10868
CRTAM cytotoxic and regulatory T cell molecule 1.01684
KLRK1 killer cell lectin-like receptor subfamily K, member 1 1.01684
CD80 CD80 molecule 1.00695
EZR ezrin 0.980987
PRKCQ protein kinase C, theta 0.963107
DCT dopachrome tautomerase 0.943059
DOCK8 dedicator of cytokinesis 8 0.94211
CD226 CD226 molecule 0.883782
HLA-B major histocompatibility complex, class I, B 0.880094
PLCG1 phospholipase C, gamma 1 0.875028
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.870885
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.856176
POM121L2 POM121 transmembrane nucleoporin-like 2 0.840564
SKAP1 src kinase associated phosphoprotein 1 0.818075
CD86 CD86 molecule 0.809817
CD276 CD276 molecule 0.79927
DIABLO diablo, IAP-binding mitochondrial protein 0.797436
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.781412
MSN moesin 0.771363
CARD11 caspase recruitment domain family, member 11 0.771363
BCL10 B-cell CLL/lymphoma 10 0.769083
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.767715
UNC13D unc-13 homolog D (C. elegans) 0.761342
RRAS2 related RAS viral (r-ras) oncogene homolog 2 0.749094
TBATA thymus, brain and testes associated 0.742769
STXBP2 syntaxin binding protein 2 0.726599
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.723472
FMNL1 formin-like 1 0.721688
CDC42 cell division cycle 42 0.708366
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.700423
RAB27A RAB27A, member RAS oncogene family 0.685954
RDX radixin 0.681591
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing 0.670725
SNX27 sorting nexin family member 27 0.664664
MAL mal, T-cell differentiation protein 0.64958
CD40 CD40 molecule, TNF receptor superfamily member 5 0.645716
PTPRJ protein tyrosine phosphatase, receptor type, J 0.625206
TBC1D10C TBC1 domain family, member 10C 0.616709
CD58 CD58 molecule 0.611625
CD200R1L CD200 receptor 1-like 0.60655
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 0.601066
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.596855
FSCN1 fascin actin-bundling protein 1 0.593912
HLA-E major histocompatibility complex, class I, E 0.593492
BTLA B and T lymphocyte associated 0.593072
WAS Wiskott-Aldrich syndrome 0.582594
BCR breakpoint cluster region 0.570913
CD40LG CD40 ligand 0.563432
DLG1 discs, large homolog 1 (Drosophila) 0.551838
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.548122
CD81 CD81 molecule 0.540706
SLAMF1 signaling lymphocytic activation molecule family member 1 0.537827
PTPN3 protein tyrosine phosphatase, non-receptor type 3 0.528798
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.528798
CORO1A coronin, actin binding protein, 1A 0.528388
DEF6 differentially expressed in FDCP 6 homolog (mouse) 0.525522
CD48 CD48 molecule 0.521841
FAT1 FAT atypical cadherin 1 0.516532
PLA2G12A phospholipase A2, group XIIA 0.495395
DBNL drebrin-like 0.492966
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.492561
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.490539
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 0.483676
IL2 interleukin 2 0.474018
GNLY granulysin 0.465998
ORAI1 ORAI calcium release-activated calcium modulator 1 0.458404
SYTL5 synaptotagmin-like 5 0.458404
SYK spleen tyrosine kinase 0.454019
GLIS2 GLIS family zinc finger 2 0.453223
LAG3 lymphocyte-activation gene 3 0.45004
INF2 inverted formin, FH2 and WH2 domain containing 0.449245
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.448451
DOK4 docking protein 4 0.445672
ICAM2 intercellular adhesion molecule 2 0.442104
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.438542
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 0.438542
THEMIS thymocyte selection associated 0.43538
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.427497
ICAM5 intercellular adhesion molecule 5, telencephalin 0.422389
CD209 CD209 molecule 0.419644
CDC42SE1 CDC42 small effector 1 0.41886
CYTIP cytohesin 1 interacting protein 0.41886
CD2AP CD2-associated protein 0.415337
MALT1 MALT1 paracaspase 0.414946
FASLG Fas ligand (TNF superfamily, member 6) 0.412992
CDC42SE2 CDC42 small effector 2 0.400139
STX12 syntaxin 12 0.399751
MCF2 MCF.2 cell line derived transforming sequence 0.394323
ICOS inducible T-cell co-stimulator 0.393549
CD9 CD9 molecule 0.392775
VAV3 vav 3 guanine nucleotide exchange factor 0.392388
CD82 CD82 molecule 0.378507
SOCS6 suppressor of cytokine signaling 6 0.378507
FYN FYN proto-oncogene, Src family tyrosine kinase 0.377738
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.377738
GRAP2 GRB2-related adaptor protein 2 0.376586
CCR7 chemokine (C-C motif) receptor 7 0.37505
STX7 syntaxin 7 0.373899
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 0.35899
SLAMF6 SLAM family member 6 0.358609
SDCBP syndecan binding protein (syntenin) 0.357467
CD19 CD19 molecule 0.354802
VTI1B vesicle transport through interaction with t-SNAREs 1B 0.351382
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.336241
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 0.33511
ICAM3 intercellular adhesion molecule 3 0.328708
WIPF1 WAS/WASL interacting protein family, member 1 0.326453
SH2D1A SH2 domain containing 1A 0.3227
WDR11 WD repeat domain 11 0.321201
FOXP3 forkhead box P3 0.315586
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.304771
ITK IL2-inducible T-cell kinase 0.303283
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 0.299569
VAV2 vav 2 guanine nucleotide exchange factor 0.294007
SYTL2 synaptotagmin-like 2 0.293637
SYT7 synaptotagmin VII 0.289938
KLRC1 killer cell lectin-like receptor subfamily C, member 1 0.284032
AS3MT arsenite methyltransferase 0.283295
ICOSLG inducible T-cell co-stimulator ligand 0.282189
SPRED1 sprouty-related, EVH1 domain containing 1 0.282189
RRAS related RAS viral (r-ras) oncogene homolog 0.275936
LY9 lymphocyte antigen 9 0.271533
PDCD1LG2 programmed cell death 1 ligand 2 0.268603
PLEK pleckstrin 0.264215
STOML2 stomatin (EPB72)-like 2 0.26312
UNC119 unc-119 homolog (C. elegans) 0.257289
KIF13B kinesin family member 13B 0.252927
PDCD6IP programmed cell death 6 interacting protein 0.252564
CD84 CD84 molecule 0.252564
FMN1 formin 1 0.251839
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.243519
HCLS1 hematopoietic cell-specific Lyn substrate 1 0.240276
UMOD uromodulin 0.238478
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.238119
CTSA cathepsin A 0.229532
CXCR4 chemokine (C-X-C motif) receptor 4 0.229532
UNC13B unc-13 homolog B (C. elegans) 0.228464
CD200R1 CD200 receptor 1 0.221025
GRB2 growth factor receptor-bound protein 2 0.220321
TSG101 tumor susceptibility 101 0.215761
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.215063
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.208137
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 0.199325
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.198325
PRDX1 peroxiredoxin 1 0.196669
CD244 CD244 molecule, natural killer cell receptor 2B4 0.194698
HLA-C major histocompatibility complex, class I, C 0.194371
GNG8 guanine nucleotide binding protein (G protein), gamma 8 0.191456
IGHV3-9 immunoglobulin heavy variable 3-9 0.190814
SCRIB scribbled planar cell polarity protein 0.187646
IGLV7-43 immunoglobulin lambda variable 7-43 0.186397
SP8 Sp8 transcription factor 0.185777
SHPK sedoheptulokinase 0.185777
BICD2 bicaudal D homolog 2 (Drosophila) 0.184853
ULBP1 UL16 binding protein 1 0.178588
EBAG9 estrogen receptor binding site associated, antigen, 9 0.175188
LGALS8 lectin, galactoside-binding, soluble, 8 0.174635
RILP Rab interacting lysosomal protein 0.172201
DOCK2 dedicator of cytokinesis 2 0.171673
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.166405
SH2B3 SH2B adaptor protein 3 0.165697
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.165697
STIM1 stromal interaction molecule 1 0.164089
NRP1 neuropilin 1 0.163641
HLA-A major histocompatibility complex, class I, A 0.162546
IL4 interleukin 4 0.160456
LYN LYN proto-oncogene, Src family tyrosine kinase 0.159462
CLEC4M C-type lectin domain family 4, member M 0.159268
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 0.159268
GUK1 guanylate kinase 1 0.159268