immunological synapse Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction. (Gene Ontology, GO_0001772)
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28 proteins localized to the immunological synapse cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SNX27 sorting nexin family member 27 0.663342
PTPRJ protein tyrosine phosphatase, receptor type, J 0.663342
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.663342
LCK LCK proto-oncogene, Src family tyrosine kinase 0.663342
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.663342
SCIMP SLP adaptor and CSK interacting membrane protein 0.663342
CD37 CD37 molecule 0.663342
SOCS6 suppressor of cytokine signaling 6 0.663342
CD81 CD81 molecule 0.663342
CD53 CD53 molecule 0.663342
DUSP3 dual specificity phosphatase 3 0.663342
DLG1 discs, large homolog 1 (Drosophila) 0.237908
LGALS3 lectin, galactoside-binding, soluble, 3 0.237908
PDCD6IP programmed cell death 6 interacting protein 0.237908
LAT linker for activation of T cells 0.237908
BCL10 B-cell CLL/lymphoma 10 0.03318
PRKCQ protein kinase C, theta 0.03318
MYH9 myosin, heavy chain 9, non-muscle 0.03318
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.03318
CD28 CD28 molecule 0.03318
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing 0.03318
CARD11 caspase recruitment domain family, member 11 0.03318
ICAM1 intercellular adhesion molecule 1 0.03318
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.03318
RHOH ras homolog family member H 0.03318
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.03318
CORO1A coronin, actin binding protein, 1A 0.03318
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.03318
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