ikappab kinase complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. (Gene Ontology, GO_0008385)
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114 proteins co-occuring with the ikappab kinase complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 3.00666
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.27752
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.12895
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 1.61706
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.48532
BCL10 B-cell CLL/lymphoma 10 1.48475
TNF tumor necrosis factor 1.41362
MALT1 MALT1 paracaspase 1.31735
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.25443
CHUK conserved helix-loop-helix ubiquitous kinase 1.18492
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 1.16953
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.11531
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 1.07207
UBE2N ubiquitin-conjugating enzyme E2N 0.97565
TBK1 TANK-binding kinase 1 0.970331
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.96792
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.939742
TRAF5 TNF receptor-associated factor 5 0.930304
IL1B interleukin 1, beta 0.811652
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.809817
CDC37 cell division cycle 37 0.792396
RNF31 ring finger protein 31 0.779583
TANK TRAF family member-associated NFKB activator 0.741416
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.728836
TRAF2 TNF receptor-associated factor 2 0.709693
IRF3 interferon regulatory factor 3 0.707482
TNIP1 TNFAIP3 interacting protein 1 0.697784
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.680284
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.648721
TMEM189 transmembrane protein 189 0.647003
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.644429
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 0.634586
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.628613
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.62393
SIVA1 SIVA1, apoptosis-inducing factor 0.620529
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.611625
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.606973
CARD11 caspase recruitment domain family, member 11 0.600644
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.59896
EDARADD EDAR-associated death domain 0.596014
IRAK4 interleukin-1 receptor-associated kinase 4 0.585105
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.575495
RIPK2 receptor-interacting serine-threonine kinase 2 0.569664
SHARPIN SHANK-associated RH domain interactor 0.565092
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.565092
TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 0.561358
TRADD TNFRSF1A-associated via death domain 0.561358
BIRC2 baculoviral IAP repeat containing 2 0.558457
MYD88 myeloid differentiation primary response 88 0.551838
TRAPPC9 trafficking protein particle complex 9 0.551425
JUN jun proto-oncogene 0.548535
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.546885
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.536183
TRAF1 TNF receptor-associated factor 1 0.510826
TRAF3 TNF receptor-associated factor 3 0.508383
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.502288
CUEDC2 CUE domain containing 2 0.499447
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.496205
RRAS related RAS viral (r-ras) oncogene homolog 0.493371
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.488115
CARD14 caspase recruitment domain family, member 14 0.472011
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.452825
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.449245
NLRP4 NLR family, pyrin domain containing 4 0.448054
IRAK1 interleukin-1 receptor-associated kinase 1 0.440916
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.427104
CD40 CD40 molecule, TNF receptor superfamily member 5 0.421212
BCL2L1 BCL2-like 1 0.405582
ZBTB17 zinc finger and BTB domain containing 17 0.396648
BATF basic leucine zipper transcription factor, ATF-like 0.387751
ZNF10 zinc finger protein 10 0.385436
CYLD cylindromatosis (turban tumor syndrome) 0.377354
PARK2 parkin RBR E3 ubiquitin protein ligase 0.366623
FAM188A family with sequence similarity 188, member A 0.365859
TRIO trio Rho guanine nucleotide exchange factor 0.359371
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B 0.357086
UBD ubiquitin D 0.356705
TRAF3IP2 TRAF3 interacting protein 2 0.356324
MIB2 mindbomb E3 ubiquitin protein ligase 2 0.351382
IRF7 interferon regulatory factor 7 0.333225
NLRC5 NLR family, CARD domain containing 5 0.332848
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.331719
HOMER3 homer scaffolding protein 3 0.326453
BIRC3 baculoviral IAP repeat containing 3 0.320451
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.315586
OPTN optineurin 0.307004
TLR4 toll-like receptor 4 0.30626
PTEN phosphatase and tensin homolog 0.305143
CCND1 cyclin D1 0.300682
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.284769
TNIK TRAF2 and NCK interacting kinase 0.278509
ICAM1 intercellular adhesion molecule 1 0.271167
IRAK2 interleukin-1 receptor-associated kinase 2 0.2708
ATG10 autophagy related 10 0.25547
ISG15 ISG15 ubiquitin-like modifier 0.252564
CARD17 caspase recruitment domain family, member 17 0.245323
FAF1 Fas (TNFRSF6) associated factor 1 0.241716
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.233101
TRAF4 TNF receptor-associated factor 4 0.217511
NOD1 nucleotide-binding oligomerization domain containing 1 0.210203
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.207451
MMP9 matrix metallopeptidase 9 0.202009
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 0.196339
SUMO3 small ubiquitin-like modifier 3 0.188274
ATM ATM serine/threonine kinase 0.183025
MAVS mitochondrial antiviral signaling protein 0.178011
GBP1 guanylate binding protein 1, interferon-inducible 0.176024
SUMO2 small ubiquitin-like modifier 2 0.176024
NCOA3 nuclear receptor coactivator 3 0.168847
RGS16 regulator of G-protein signaling 16 0.165697
PRKD1 protein kinase D1 0.161693
CARD9 caspase recruitment domain family, member 9 0.157218
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.156863
ZHX2 zinc fingers and homeoboxes 2 0.156688