ikappab kinase complex Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. (Gene Ontology, GO_0008385)
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Genes

7 proteins localized to the ikappab kinase complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.663342
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.663342
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.663342
CHUK conserved helix-loop-helix ubiquitous kinase 0.663342
PYCARD PYD and CARD domain containing 0.237908
TRIM40 tripartite motif containing 40 0.237908
PYDC1 PYD (pyrin domain) containing 1 0.237908