idiopathic pulmonary fibrosis Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An idiopathic interstitial pneumonia which is a distinctive type of chronic fibrosing interstitial pneumonia with thick scarring in the lung creating a honeycomb appearance. The main symptoms start insidiously as shortness of breath on exertion, cough, and diminished stamina. Other common complaints include weight loss and fatigue. The level of oxygen in the blood decreases, and the skin may take on a bluish tinge (called cyanosis) and the ends of the fingers may become thick or club-shape. In most people, symptoms worsen over a period ranging from about 6 months to several years. (Human Disease Ontology, DOID_0050156)
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Genes

16 genes associated with the disease idiopathic pulmonary fibrosis in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL5 chemokine (C-X-C motif) ligand 5
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
IL6 interleukin 6
LTA lymphotoxin alpha
MICA MHC class I polypeptide-related sequence A
MMP1 matrix metallopeptidase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
VEGFA vascular endothelial growth factor A