idiopathic pulmonary fibrosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An idiopathic interstitial pneumonia which is a distinctive type of chronic fibrosing interstitial pneumonia with thick scarring in the lung creating a honeycomb appearance. The main symptoms start insidiously as shortness of breath on exertion, cough, and diminished stamina. Other common complaints include weight loss and fatigue. The level of oxygen in the blood decreases, and the skin may take on a bluish tinge (called cyanosis) and the ends of the fingers may become thick or club-shape. In most people, symptoms worsen over a period ranging from about 6 months to several years. (Human Disease Ontology, DOID_0050156)
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Genes

298 genes co-occuring with the disease idiopathic pulmonary fibrosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TGFB1 transforming growth factor, beta 1 1.65295
SFTPC surfactant protein C 1.53701
MUC1 mucin 1, cell surface associated 1.52512
SFTPD surfactant protein D 1.37774
FN1 fibronectin 1 1.33327
SMAD3 SMAD family member 3 1.29615
MMP7 matrix metallopeptidase 7 1.21219
SFTPA2 surfactant protein A2 1.20569
CTGF connective tissue growth factor 1.18626
TERT telomerase reverse transcriptase 1.16863
SMAD2 SMAD family member 2 1.16563
MUC5B mucin 5B, oligomeric mucus/gel-forming 1.13755
ELMOD2 ELMO/CED-12 domain containing 2 1.12952
NOP10 NOP10 ribonucleoprotein 1.0324
DKC1 dyskeratosis congenita 1, dyskerin 1.01891
IL1B interleukin 1, beta 1.01596
NHP2 NHP2 ribonucleoprotein 1.00668
CCL2 chemokine (C-C motif) ligand 2 0.978848
CCL13 chemokine (C-C motif) ligand 13 0.978848
NOX4 NADPH oxidase 4 0.942443
CXCL8 chemokine (C-X-C motif) ligand 8 0.932484
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.928346
CD4 CD4 molecule 0.920085
CXCL10 chemokine (C-X-C motif) ligand 10 0.917611
CCL17 chemokine (C-C motif) ligand 17 0.915139
TNF tumor necrosis factor 0.898693
LTBP1 latent transforming growth factor beta binding protein 1 0.885979
SFTPA1 surfactant protein A1 0.880243
CXCL5 chemokine (C-X-C motif) ligand 5 0.871643
TIMP1 TIMP metallopeptidase inhibitor 1 0.857724
PPL periplakin 0.813052
MMP9 matrix metallopeptidase 9 0.800333
CCL22 chemokine (C-C motif) ligand 22 0.781888
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.78066
MMP1 matrix metallopeptidase 1 0.776977
CCL3 chemokine (C-C motif) ligand 3 0.774932
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.767985
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.756156
PDGFB platelet-derived growth factor beta polypeptide 0.749644
FASLG Fas ligand (TNF superfamily, member 6) 0.731381
AGER advanced glycosylation end product-specific receptor 0.728143
WISP1 WNT1 inducible signaling pathway protein 1 0.721673
CXCL11 chemokine (C-X-C motif) ligand 11 0.714005
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 0.709169
MPO myeloperoxidase 0.706351
DDR1 discoidin domain receptor tyrosine kinase 1 0.700321
SMAD7 SMAD family member 7 0.699919
MMP2 matrix metallopeptidase 2 0.694702
AEBP1 AE binding protein 1 0.692296
TNC tenascin C 0.679898
CXCR3 chemokine (C-X-C motif) receptor 3 0.6791
EDN1 endothelin 1 0.675909
ZNF467 zinc finger protein 467 0.666358
LIPF lipase, gastric 0.663181
FGF2 fibroblast growth factor 2 (basic) 0.662387
PROS2P protein S (beta) pseudogene 0.662387
COL3A1 collagen, type III, alpha 1 0.643404
LCLAT1 lysocardiolipin acyltransferase 1 0.631991
ALB albumin 0.628457
ART5 ADP-ribosyltransferase 5 0.626888
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.623359
CXCL12 chemokine (C-X-C motif) ligand 12 0.620617
LPAR1 lysophosphatidic acid receptor 1 0.61866
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 0.612401
SFTPB surfactant protein B 0.609666
CXCL17 chemokine (C-X-C motif) ligand 17 0.607323
SPPL2C signal peptide peptidase like 2C 0.59913
MMP8 matrix metallopeptidase 8 0.594843
F2RL1 coagulation factor II (thrombin) receptor-like 1 0.590169
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.586276
AQP5 aquaporin 5 0.581996
IGF1 insulin-like growth factor 1 (somatomedin C) 0.577716
ACTA2 actin, alpha 2, smooth muscle, aorta 0.577327
ANKRD42 ankyrin repeat domain 42 0.575383
S100A9 S100 calcium binding protein A9 0.569552
WNT3A wingless-type MMTV integration site family, member 3A 0.569163
XBP1 X-box binding protein 1 0.5645
SOD3 superoxide dismutase 3, extracellular 0.556344
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.550134
B3GAT3 beta-1,3-glucuronyltransferase 3 0.548583
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.541217
IGFBP5 insulin-like growth factor binding protein 5 0.538506
SRXN1 sulfiredoxin 1 0.533088
IL1RN interleukin 1 receptor antagonist 0.531928
TOLLIP toll interacting protein 0.524974
CXCR2 chemokine (C-X-C motif) receptor 2 0.504973
IL13 interleukin 13 0.503441
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.502675
GSX1 GS homeobox 1 0.501909
COL1A2 collagen, type I, alpha 2 0.500379
F2RL3 coagulation factor II (thrombin) receptor-like 3 0.499614
WNT7B wingless-type MMTV integration site family, member 7B 0.498467
ARID3A AT rich interactive domain 3A (BRIGHT-like) 0.497321
CAV1 caveolin 1, caveolae protein, 22kDa 0.493122
ROMO1 reactive oxygen species modulator 1 0.490454
ELANE elastase, neutrophil expressed 0.487027
LPAR4 lysophosphatidic acid receptor 4 0.486646
HPS1 Hermansky-Pudlak syndrome 1 0.483985
BPIFA1 BPI fold containing family A, member 1 0.483985
S100A4 S100 calcium binding protein A4 0.483224
NOX1 NADPH oxidase 1 0.483224
COL1A1 collagen, type I, alpha 1 0.478289
CXCL9 chemokine (C-X-C motif) ligand 9 0.471468
CCR2 chemokine (C-C motif) receptor 2 0.471468
CCR7 chemokine (C-C motif) receptor 7 0.465794
PPT1 palmitoyl-protein thioesterase 1 0.465038
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.460883
PTK2 protein tyrosine kinase 2 0.459751
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 0.458619
MPHOSPH9 M-phase phosphoprotein 9 0.455224
TP53 tumor protein p53 0.454093
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.452585
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.449571
LPAR2 lysophosphatidic acid receptor 2 0.448064
CCL21 chemokine (C-C motif) ligand 21 0.438282
CRP C-reactive protein, pentraxin-related 0.435275
IL1A interleukin 1, alpha 0.433021
SOCS1 suppressor of cytokine signaling 1 0.431894
CRIP1 cysteine-rich protein 1 (intestinal) 0.431519
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.430768
RETNLB resistin like beta 0.428516
AARS alanyl-tRNA synthetase 0.426265
HAVCR2 hepatitis A virus cellular receptor 2 0.42214
ACE angiotensin I converting enzyme 0.421765
TMOD3 tropomodulin 3 (ubiquitous) 0.415024
MKL1 megakaryoblastic leukemia (translocation) 1 0.413527
THY1 Thy-1 cell surface antigen 0.412031
CCL16 chemokine (C-C motif) ligand 16 0.407919
GRHL2 grainyhead-like 2 (Drosophila) 0.404184
DCLRE1C DNA cross-link repair 1C 0.400826
ICAM1 intercellular adhesion molecule 1 0.398216
HPS6 Hermansky-Pudlak syndrome 6 0.396725
KREMEN1 kringle containing transmembrane protein 1 0.395235
MAPK8 mitogen-activated protein kinase 8 0.394118
F3 coagulation factor III (thromboplastin, tissue factor) 0.392257
SOD2 superoxide dismutase 2, mitochondrial 0.388538
WAPAL wings apart-like homolog (Drosophila) 0.387051
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.386679
IL22RA2 interleukin 22 receptor, alpha 2 0.383337
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.382594
CD68 CD68 molecule 0.38111
TLR9 toll-like receptor 9 0.379256
FGF7 fibroblast growth factor 7 0.378514
DNTT DNA nucleotidylexotransferase 0.377773
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.375179
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.374438
STK17B serine/threonine kinase 17b 0.373698
VEGFA vascular endothelial growth factor A 0.372587
JUN jun proto-oncogene 0.371107
FIGF c-fos induced growth factor (vascular endothelial growth factor D) 0.36704
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.365932
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.364824
TJP1 tight junction protein 1 0.362609
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.361133
POSTN periostin, osteoblast specific factor 0.358551
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.358551
NEIL3 nei endonuclease VIII-like 3 (E. coli) 0.355604
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 0.355235
CD79A CD79a molecule, immunoglobulin-associated alpha 0.355235
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 0.354131
PTEN phosphatase and tensin homolog 0.353763
IL6 interleukin 6 0.353027
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.350452
CARD10 caspase recruitment domain family, member 10 0.348614
IL10 interleukin 10 0.348246
PPP6R2 protein phosphatase 6, regulatory subunit 2 0.345675
SAMD7 sterile alpha motif domain containing 7 0.345308
EDNRA endothelin receptor type A 0.344207
SHH sonic hedgehog 0.341639
KLK8 kallikrein-related peptidase 8 0.335412
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma 0.333949
ERAS ES cell expressed Ras 0.330295
LOX lysyl oxidase 0.3292
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 0.326281
SNAI1 snail family zinc finger 1 0.325916
TADA3 transcriptional adaptor 3 0.324823
COL6A3 collagen, type VI, alpha 3 0.324458
CAPG capping protein (actin filament), gelsolin-like 0.321909
MMP12 matrix metallopeptidase 12 0.321181
TIMP2 TIMP metallopeptidase inhibitor 2 0.316819
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.315003
IL2RA interleukin 2 receptor, alpha 0.311014
CMA1 chymase 1, mast cell 0.309204
FHIT fragile histidine triad 0.308842
HMGB1 high mobility group box 1 0.307757
MAP2K5 mitogen-activated protein kinase kinase 5 0.307033
FGF1 fibroblast growth factor 1 (acidic) 0.303059
ADGRE1 adhesion G protein-coupled receptor E1 0.297291
DEFA3 defensin, alpha 3, neutrophil-specific 0.29118
KEAP1 kelch-like ECH-associated protein 1 0.290462
FOXA3 forkhead box A3 0.287235
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.282225
VCAN versican 0.280439
DEFB104B defensin, beta 104B 0.277227
OPTN optineurin 0.276158
DEFA1 defensin, alpha 1 0.275445
DEFA1B defensin, alpha 1B 0.275445
CD151 CD151 molecule (Raph blood group) 0.272597
SPP1 secreted phosphoprotein 1 0.269398
DEFB1 defensin, beta 1 0.269043
DMBT1 deleted in malignant brain tumors 1 0.268687
KRT8 keratin 8, type II 0.263014
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.26266
CD34 CD34 molecule 0.261245
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 0.260891
LTB4R leukotriene B4 receptor 0.260891
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.257358
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.257005
MIR21 microRNA 21 0.254536
AKAP9 A kinase (PRKA) anchor protein 9 0.251718
H3F3A H3 histone, family 3A 0.251015
H3F3B H3 histone, family 3B (H3.3B) 0.251015
IGFBP3 insulin-like growth factor binding protein 3 0.24715
TGFB3 transforming growth factor, beta 3 0.245046
FGF10 fibroblast growth factor 10 0.242945
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative) 0.242945
ART1 ADP-ribosyltransferase 1 0.242595
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 0.240497
ADAM19 ADAM metallopeptidase domain 19 0.239799
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 0.23945
IL17RB interleukin 17 receptor B 0.238403
TIMP4 TIMP metallopeptidase inhibitor 4 0.236312
TGFBR1 transforming growth factor, beta receptor 1 0.236312
TLR3 toll-like receptor 3 0.235616
HIPK2 homeodomain interacting protein kinase 2 0.235616
SMO smoothened, frizzled class receptor 0.235616
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.234573
USB1 U6 snRNA biogenesis 1 0.22937
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) 0.228679
IL23A interleukin 23, alpha subunit p19 0.225917
S100A8 S100 calcium binding protein A8 0.224884
KRT19 keratin 19, type I 0.222822
ECE1 endothelin converting enzyme 1 0.222479
PLG plasminogen 0.221793
YY1 YY1 transcription factor 0.219398
MIR210 microRNA 210 0.219398
TAGLN2 transgelin 2 0.218715
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 0.218034
MIR185 microRNA 185 0.215992
ART3 ADP-ribosyltransferase 3 0.215992
FOXP3 forkhead box P3 0.209918
HDAC4 histone deacetylase 4 0.208579
IL4R interleukin 4 receptor 0.208579
DKK4 dickkopf WNT signaling pathway inhibitor 4 0.204923
IL1R1 interleukin 1 receptor, type I 0.202618
MIRLET7D microRNA let-7d 0.20229
CCL4 chemokine (C-C motif) ligand 4 0.201308
NMNAT1 nicotinamide nucleotide adenylyltransferase 1 0.200982
RTEL1 regulator of telomere elongation helicase 1 0.200006
F2R coagulation factor II (thrombin) receptor 0.198709
TIGAR TP53 induced glycolysis regulatory phosphatase 0.198709
TMEM67 transmembrane protein 67 0.198386
MMP25 matrix metallopeptidase 25 0.197099
ING4 inhibitor of growth family, member 4 0.196139
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.195183
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 0.194865
CALCR calcitonin receptor 0.192344
MAP2K1 mitogen-activated protein kinase kinase 1 0.191097
GRP gastrin-releasing peptide 0.189551
CD53 CD53 molecule 0.188632
ISPD isoprenoid synthase domain containing 0.188632
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.188022
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.188022
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.187719
CNTFR ciliary neurotrophic factor receptor 0.18651
AGO1 argonaute RISC catalytic component 1 0.18591
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.18472
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3 0.184424
KRT18 keratin 18, type I 0.183541
C5AR1 complement component 5a receptor 1 0.18151
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 0.181222
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.17952
PIDD1 p53-induced death domain protein 1 0.17896
DNM2 dynamin 2 0.177851
TFRC transferrin receptor 0.177029
ARG1 arginase 1 0.175947
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.175146
HDAC9 histone deacetylase 9 0.175146
HLTF helicase-like transcription factor 0.174881
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.174617
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.172799
IL4 interleukin 4 0.171785
BMP4 bone morphogenetic protein 4 0.167915
FZD2 frizzled class receptor 2 0.166995
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.166319
FBN2 fibrillin 2 0.166095
WNT1 wingless-type MMTV integration site family, member 1 0.165435
CCL19 chemokine (C-C motif) ligand 19 0.165217
DDIT3 DNA-damage-inducible transcript 3 0.163111
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.163111
SULF2 sulfatase 2 0.162109
CD83 CD83 molecule 0.161716
OLFM4 olfactomedin 4 0.161331
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.160203
CD207 CD207 molecule, langerin 0.159838
RNASE3 ribonuclease, RNase A family, 3 0.159124
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.158778
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.157602