i-kappab kinase/nf-kappab signaling Gene Set

Dataset GO Biological Process Annotations
Category structural or functional annotations
Type biological process
Description The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. (Gene Ontology, GO_0007249)
External Link http://amigo.geneontology.org/amigo/term/GO:0007249
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Genes

44 genes participating in the i-kappab kinase/nf-kappab signaling biological process from the curated GO Biological Process Annotations dataset.

Symbol Name
AVPR2 arginine vasopressin receptor 2
AZI2 5-azacytidine induced 2
BCL3 B-cell CLL/lymphoma 3
BTK Bruton agammaglobulinemia tyrosine kinase
CD14 CD14 molecule
CHUK conserved helix-loop-helix ubiquitous kinase
HACD3 3-hydroxyacyl-CoA dehydratase 3
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1
IRAK2 interleukin-1 receptor-associated kinase 2
LY96 lymphocyte antigen 96
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAP3K7 mitogen-activated protein kinase kinase kinase 7
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NKIRAS1 NFKB inhibitor interacting Ras-like 1
NKIRAS2 NFKB inhibitor interacting Ras-like 2
NLRC3 NLR family, CARD domain containing 3
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIPK2 receptor-interacting serine-threonine kinase 2
RIPK3 receptor-interacting serine-threonine kinase 3
RPS27A ribosomal protein S27a
SNIP1 Smad nuclear interacting protein 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3
TANK TRAF family member-associated NFKB activator
TBK1 TANK-binding kinase 1
TIAF1 TGFB1-induced anti-apoptotic factor 1
TICAM1 toll-like receptor adaptor molecule 1
TIFA TRAF-interacting protein with forkhead-associated domain
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TLR8 toll-like receptor 8
TNIP2 TNFAIP3 interacting protein 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
ZNF675 zinc finger protein 675