hypothyroidism Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A thyroid gland disease which involves an underproduction of thyroid hormone. (Human Disease Ontology, DOID_1459)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0000821
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Genes

79 genes associated with the hypothyroidism phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
SH2B3 SH2B adaptor protein 3 1.53903
ATXN2 ataxin 2 1.52822
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 1.40373
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 1.38752
VAV3 vav 3 guanine nucleotide exchange factor 1.36327
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.30029
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor 1.0158
HLA-B major histocompatibility complex, class I, B 1.01103
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.00059
PDE8B phosphodiesterase 8B 1.00059
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.984214
C6ORF15 chromosome 6 open reading frame 15 0.969142
INSR insulin receptor 0.919744
RECQL5 RecQ protein-like 5 0.887931
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.882984
ASIC2 acid sensing (proton gated) ion channel 2 0.882984
ZNF804B zinc finger protein 804B 0.882984
C1QTNF6 C1q and tumor necrosis factor related protein 6 0.855449
MTF1 metal-regulatory transcription factor 1 0.855449
HCG22 HLA complex group 22 0.849662
LOC100506999 uncharacterized LOC100506999 0.825497
TSHZ2 teashirt zinc finger homeobox 2 0.825497
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 0.802966
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.7965
PFKP phosphofructokinase, platelet 0.790435
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.784165
RAB20 RAB20, member RAS oncogene family 0.767696
CLECL1 C-type lectin-like 1 0.767696
CALN1 calneuron 1 0.762459
PRKCE protein kinase C, epsilon 0.752335
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.738997
ZDHHC17 zinc finger, DHHC-type containing 17 0.734535
THSD4 thrombospondin, type I, domain containing 4 0.726078
PCDH15 protocadherin-related 15 0.726078
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.703894
SNAP47 synaptosomal-associated protein, 47kDa 0.700393
AGER advanced glycosylation end product-specific receptor 0.693745
BTNL2 butyrophilin-like 2 0.690584
CNTNAP2 contactin associated protein-like 2 0.678743
FOXE1 forkhead box E1 0.672779
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa 0.667145
FKTN fukutin 0.664442
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.647116
RBP4 retinol binding protein 4, plasma 0.642222
VMP1 vacuole membrane protein 1 0.639858
TTLL6 tubulin tyrosine ligase-like family member 6 0.633071
TRIM15 tripartite motif containing 15 0.630903
CAPZB capping protein (actin filament) muscle Z-line, beta 0.630903
ANKRD26 ankyrin repeat domain 26 0.626701
DFNB31 deafness, autosomal recessive 31 0.621485
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.618783
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 0.618783
IL2RA interleukin 2 receptor, alpha 0.613082
CLDN2 claudin 2 0.613082
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.611229
KIRREL3 kin of IRRE like 3 (Drosophila) 0.611229
CHL1 cell adhesion molecule L1-like 0.609408
KLHL29 kelch-like family member 29 0.609408
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.609408
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.60762
URI1 URI1, prefoldin-like chaperone 0.605862
OPCML opioid binding protein/cell adhesion molecule-like 0.600766
DAAM1 dishevelled associated activator of morphogenesis 1 0.595915
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.592807
TNNT3 troponin T type 3 (skeletal, fast) 0.591289
CNTN4 contactin 4 0.589794
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.588321
GPC5 glypican 5 0.588321
ERICH1 glutamate-rich 1 0.583059
PDE10A phosphodiesterase 10A 0.581861
ERCC5 excision repair cross-complementation group 5 0.57836
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.57836
MACROD2 MACRO domain containing 2 0.574995
MAN1C1 mannosidase, alpha, class 1C, member 1 0.573902
HCG9 HLA complex group 9 (non-protein coding) 0.487671
FGFR1OP FGFR1 oncogene partner 0.462619
LEMD2 LEM domain containing 2 0.425272
CLEC16A C-type lectin domain family 16, member A 0.425272
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.425039