hypoalgesia Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description decreased sensitivity to painful stimuli; can be due to chemical intervention, neuropathies or due to damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area) (Mammalian Phenotype Ontology, MP_0003043)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0003043
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Genes

123 gene mutations causing the hypoalgesia phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADCY1 adenylate cyclase 1 (brain)
ADCY8 adenylate cyclase 8 (brain)
ADORA2A adenosine A2a receptor
AGTR2 angiotensin II receptor, type 2
ASIC3 acid sensing (proton gated) ion channel 3
BAMBI BMP and activin membrane-bound inhibitor
BBS2 Bardet-Biedl syndrome 2
BBS4 Bardet-Biedl syndrome 4
BDKRB1 bradykinin receptor B1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CALCB calcitonin-related polypeptide beta
CAPN7 calpain 7
CCKBR cholecystokinin B receptor
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CEP41 centrosomal protein 41kDa
CLCN6 chloride channel, voltage-sensitive 6
CLP1 cleavage and polyadenylation factor I subunit 1
CNR1 cannabinoid receptor 1 (brain)
CPE carboxypeptidase E
CTSC cathepsin C
DFNB31 deafness, autosomal recessive 31
EDNRB endothelin receptor type B
ERBB2IP erbb2 interacting protein
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FAAH fatty acid amide hydrolase
FLNC filamin C, gamma
FMR1 fragile X mental retardation 1
FRZB frizzled-related protein
FXR2 fragile X mental retardation, autosomal homolog 2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GALR2 galanin receptor 2
GBX1 gastrulation brain homeobox 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GPR3 G protein-coupled receptor 3
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIK1 glutamate receptor, ionotropic, kainate 1
GRIK5 glutamate receptor, ionotropic, kainate 5
GRK5 G protein-coupled receptor kinase 5
GRM5 glutamate receptor, metabotropic 5
HDAC4 histone deacetylase 4
HDC histidine decarboxylase
HMGN3 high mobility group nucleosomal binding domain 3
HOXB13 homeobox B13
HOXB8 homeobox B8
HOXD1 homeobox D1
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IL10 interleukin 10
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KCNIP3 Kv channel interacting protein 3, calsenilin
KDM8 lysine (K)-specific demethylase 8
KIF1A kinesin family member 1A
LEP leptin
LGALS1 lectin, galactoside-binding, soluble, 1
LPAR5 lysophosphatidic acid receptor 5
LXN latexin
MADD MAP-kinase activating death domain
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5
MECP2 methyl CpG binding protein 2
MGLL monoglyceride lipase
MMP9 matrix metallopeptidase 9
MRGPRD MAS-related GPR, member D
MYO7A myosin VIIA
MYSM1 Myb-like, SWIRM and MPN domains 1
NAV2 neuron navigator 2
NDN necdin, melanoma antigen (MAGE) family member
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NF2 neurofibromin 2 (merlin)
NGF nerve growth factor (beta polypeptide)
NMUR2 neuromedin U receptor 2
NPEPPS aminopeptidase puromycin sensitive
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTSR2 neurotensin receptor 2
OPRM1 opioid receptor, mu 1
OSM oncostatin M
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PCSK2 proprotein convertase subtilisin/kexin type 2
PIRT phosphoinositide-interacting regulator of transient receptor potential channels
POMK protein-O-mannose kinase
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PRLHR prolactin releasing hormone receptor
PROKR1 prokineticin receptor 1
PRX periaxin
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RALBP1 ralA binding protein 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SHANK3 SH3 and multiple ankyrin repeat domains 3
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SPP1 secreted phosphoprotein 1
SRSF4 serine/arginine-rich splicing factor 4
STOML3 stomatin (EPB72)-like 3
TAC1 tachykinin, precursor 1
TACR1 tachykinin receptor 1
TLR4 toll-like receptor 4
TPP1 tripeptidyl peptidase I
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TRPM8 transient receptor potential cation channel, subfamily M, member 8
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV3 transient receptor potential cation channel, subfamily V, member 3
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSHZ3 teashirt zinc finger homeobox 3
UBE3B ubiquitin protein ligase E3B
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VWA1 von Willebrand factor A domain containing 1