hypertension Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. (Experimental Factor Ontology, EFO_0000537)
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Genes

63 proteins co-occuring with the biological term hypertension in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
AKT1 v-akt murine thymoma viral oncogene homolog 1
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
CDK2 cyclin-dependent kinase 2
CLDN7 claudin 7
CREB1 cAMP responsive element binding protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
DNM1L dynamin 1-like
EEF2 eukaryotic translation elongation factor 2
EGFR epidermal growth factor receptor
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
EIF4E eukaryotic translation initiation factor 4E
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
GATA4 GATA binding protein 4
GOLGA2 golgin A2
GSK3B glycogen synthase kinase 3 beta
IGF1R insulin-like growth factor 1 receptor
INSR insulin receptor
IRS1 insulin receptor substrate 1
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
LRP6 low density lipoprotein receptor-related protein 6
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MSN moesin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NOS3 nitric oxide synthase 3 (endothelial cell)
OXSR1 oxidative stress responsive 1
PEBP1 phosphatidylethanolamine binding protein 1
PLN phospholamban
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCA protein kinase C, alpha
PTK2 protein tyrosine kinase 2
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RGS2 regulator of G-protein signaling 2
RHOA ras homolog family member A
RPS6 ribosomal protein S6
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SCNN1B sodium channel, non voltage gated 1 beta subunit
SGK1 serum/glucocorticoid regulated kinase 1
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK39 serine threonine kinase 39
SYT2 synaptotagmin II
TPM1 tropomyosin 1 (alpha)
TSC2 tuberous sclerosis 2
VASP vasodilator-stimulated phosphoprotein
WNK1 WNK lysine deficient protein kinase 1
WNK4 WNK lysine deficient protein kinase 4