hypertension Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0000822
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Genes

341 genes associated with the hypertension phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
ZFAT zinc finger and AT hook domain containing 2.49937
NOS3 nitric oxide synthase 3 (endothelial cell) 1.75912
PRKCE protein kinase C, epsilon 1.72215
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 1.70448
HK1 hexokinase 1 1.63258
TMPRSS6 transmembrane protease, serine 6 1.61591
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 1.48419
UMOD uromodulin 1.46277
ARHGAP42 Rho GTPase activating protein 42 1.45654
BAG6 BCL2-associated athanogene 6 1.43716
LPL lipoprotein lipase 1.43716
GPR39 G protein-coupled receptor 39 1.43716
HFE hemochromatosis 1.41863
MYO6 myosin VI 1.40061
GCKR glucokinase (hexokinase 4) regulator 1.40061
TFR2 transferrin receptor 2 1.38847
BUD13 BUD13 homolog (S. cerevisiae) 1.30781
MACROD2 MACRO domain containing 2 1.26545
NELL1 NEL-like 1 (chicken) 1.26545
PLCE1 phospholipase C, epsilon 1 1.25251
PAX5 paired box 5 1.25251
LRRC7 leucine rich repeat containing 7 1.19958
APOA5 apolipoprotein A-V 1.18704
FCRL1 Fc receptor-like 1 1.17957
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 1.17192
NELFCD negative elongation factor complex member C/D 1.17192
PRKCA protein kinase C, alpha 1.17174
VTA1 vesicle (multivesicular body) trafficking 1 1.15352
ZNF618 zinc finger protein 618 1.14655
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 1.12851
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 1.12851
NFIB nuclear factor I/B 1.12456
PIEZO2 piezo-type mechanosensitive ion channel component 2 1.11203
GSTCD glutathione S-transferase, C-terminal domain containing 1.08797
SLC39A8 solute carrier family 39 (zinc transporter), member 8 1.08774
MEF2C myocyte enhancer factor 2C 1.08774
FES FES proto-oncogene, tyrosine kinase 1.0674
NLGN1 neuroligin 1 1.06676
ASPG asparaginase 1.06211
AGBL1 ATP/GTP binding protein-like 1 1.05869
GDF3 growth differentiation factor 3 1.05616
PLG plasminogen 1.0543
LOC339529 uncharacterized LOC339529 1.04365
ARHGAP29 Rho GTPase activating protein 29 1.04365
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 1.02868
CCAR1 cell division cycle and apoptosis regulator 1 1.02549
ALX4 ALX homeobox 4 1.01962
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 1.01768
RORA RAR-related orphan receptor A 1.00952
MYH11 myosin, heavy chain 11, smooth muscle 1.00059
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 1.00059
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 1.00059
SEC31B SEC31 homolog B (S. cerevisiae) 1.00059
GPC6 glypican 6 1.00059
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.999507
SDCBP2 syndecan binding protein (syntenin) 2 0.994551
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.988702
UNC5CL unc-5 homolog C (C. elegans)-like 0.98364
CNTN4 contactin 4 0.971944
TMC6 transmembrane channel-like 6 0.969142
CNTNAP5 contactin associated protein-like 5 0.969142
AK5 adenylate kinase 5 0.962749
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.952117
MPPED2 metallophosphoesterase domain containing 2 0.951856
WWC1 WW and C2 domain containing 1 0.948789
EYA2 EYA transcriptional coactivator and phosphatase 2 0.947546
KDM4A lysine (K)-specific demethylase 4A 0.942765
SLC35F1 solute carrier family 35, member F1 0.942765
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.942765
MSRA methionine sulfoxide reductase A 0.942765
MPZL3 myelin protein zero-like 3 0.942765
FMN2 formin 2 0.942765
ARMC9 armadillo repeat containing 9 0.942765
TNR tenascin R 0.942765
MIPEPP3 mitochondrial intermediate peptidase pseudogene 3 0.942765
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.942765
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.935362
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.929444
LOC643339 uncharacterized LOC643339 0.928309
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 0.926745
CHD2 chromodomain helicase DNA binding protein 2 0.925427
PCDH15 protocadherin-related 15 0.923276
ADAMTSL1 ADAMTS-like 1 0.922222
GPATCH2L G patch domain containing 2-like 0.922222
MYO1D myosin ID 0.919744
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.919744
ELMSAN1 ELM2 and Myb/SANT-like domain containing 1 0.919744
COL8A1 collagen, type VIII, alpha 1 0.914846
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.914419
SYNE1 spectrin repeat containing, nuclear envelope 1 0.913994
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.911691
FCRL2 Fc receptor-like 2 0.906866
TRIM54 tripartite motif containing 54 0.901186
EFCAB11 EF-hand calcium binding domain 11 0.899912
YEATS4 YEATS domain containing 4 0.899912
ARRB1 arrestin, beta 1 0.899912
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.899731
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 0.891813
C8ORF34 chromosome 8 open reading frame 34 0.891649
BMPR1B bone morphogenetic protein receptor, type IB 0.882984
TSPO2 translocator protein 2 0.880922
THSD4 thrombospondin, type I, domain containing 4 0.880453
PACRG PARK2 co-regulated 0.879677
UBQLN1 ubiquilin 1 0.875451
EML5 echinoderm microtubule associated protein like 5 0.874717
FSTL4 follistatin-like 4 0.87156
ZNF221 zinc finger protein 221 0.869196
STOX2 storkhead box 2 0.868241
PHB prohibitin 0.868241
AGO2 argonaute RISC catalytic component 2 0.868241
EXOC4 exocyst complex component 4 0.868241
PHF10 PHD finger protein 10 0.868241
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 0.868241
C1ORF27 chromosome 1 open reading frame 27 0.868241
CNTN5 contactin 5 0.86743
MPV17 MpV17 mitochondrial inner membrane protein 0.866229
JAZF1 JAZF zinc finger 1 0.859871
PKD1L1 polycystic kidney disease 1 like 1 0.85593
ADAM12 ADAM metallopeptidase domain 12 0.855449
SLC39A11 solute carrier family 39, member 11 0.855449
SLCO2B1 solute carrier organic anion transporter family, member 2B1 0.851243
PLCB4 phospholipase C, beta 4 0.849438
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 0.849327
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.849215
WDR4 WD repeat domain 4 0.845725
NPAS2 neuronal PAS domain protein 2 0.840142
ARPP19 cAMP-regulated phosphoprotein, 19kDa 0.839148
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 0.838165
TF transferrin 0.824663
COL23A1 collagen, type XXIII, alpha 1 0.823019
PRKG1 protein kinase, cGMP-dependent, type I 0.81905
CD276 CD276 molecule 0.817516
PVT1 Pvt1 oncogene (non-protein coding) 0.817516
SERGEF secretion regulating guanine nucleotide exchange factor 0.810722
IDNK idnK, gluconokinase homolog (E. coli) 0.810722
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.802966
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 0.800318
COL4A1 collagen, type IV, alpha 1 0.797753
RHOBTB2 Rho-related BTB domain containing 2 0.797753
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.7965
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.7965
INTS12 integrator complex subunit 12 0.794052
CCDC180 coiled-coil domain containing 180 0.790435
FRMD4A FERM domain containing 4A 0.790435
ADD2 adducin 2 (beta) 0.790435
UNQ6494 uncharacterized LOC100129066 0.790435
CHN2 chimerin 2 0.786
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.784165
TP63 tumor protein p63 0.784165
DNAH5 dynein, axonemal, heavy chain 5 0.782369
MIR1-1HG MIR1-1 host gene 0.781779
UNC13C unc-13 homolog C (C. elegans) 0.779456
HOTTIP HOXA distal transcript antisense RNA 0.772313
HPCAL1 hippocalcin-like 1 0.771787
GAB1 GRB2-associated binding protein 1 0.770746
MAPK10 mitogen-activated protein kinase 10 0.768197
SLIT3 slit homolog 3 (Drosophila) 0.766212
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.762996
FRMD6 FERM domain containing 6 0.756753
ETV6 ets variant 6 0.756252
C9ORF129 chromosome 9 open reading frame 129 0.753299
LARGE like-glycosyltransferase 0.751382
SEPT9 septin 9 0.751382
CHODL chondrolectin 0.750439
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.747212
DPYD dihydropyrimidine dehydrogenase 0.745419
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.743226
CD163L1 CD163 molecule-like 1 0.740664
CYLD cylindromatosis (turban tumor syndrome) 0.739411
COL28A1 collagen, type XXVIII, alpha 1 0.735423
FTO fat mass and obesity associated 0.735423
ANO2 anoctamin 2, calcium activated chloride channel 0.734535
GBGT1 globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 0.730636
TSSC1 tumor suppressing subtransferable candidate 1 0.730213
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.728954
CCSER1 coiled-coil serine-rich protein 1 0.728123
THSD7A thrombospondin, type I, domain containing 7A 0.7273
PHTF2 putative homeodomain transcription factor 2 0.722896
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 0.717942
RGS7 regulator of G-protein signaling 7 0.717203
LEKR1 leucine, glutamate and lysine rich 1 0.712186
NTN1 netrin 1 0.710458
PTPRD protein tyrosine phosphatase, receptor type, D 0.707893
ING3 inhibitor of growth family, member 3 0.707523
SOX5 SRY (sex determining region Y)-box 5 0.706786
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K 0.706055
C15ORF41 chromosome 15 open reading frame 41 0.704251
CSF3R colony stimulating factor 3 receptor (granulocyte) 0.703894
CROT carnitine O-octanoyltransferase 0.701084
ATRAID all-trans retinoic acid-induced differentiation factor 0.700393
CELF5 CUGBP, Elav-like family member 5 0.69768
MSI2 musashi RNA-binding protein 2 0.69768
LOC285000 uncharacterized LOC285000 0.696681
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.694067
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.692152
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.689656
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.686922
TMX4 thioredoxin-related transmembrane protein 4 0.685437
FSCN1 fascin actin-bundling protein 1 0.684849
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.683107
LHFPL3 lipoma HMGIC fusion partner-like 3 0.682533
CWC22 CWC22 spliceosome-associated protein 0.681679
MRGPRE MAS-related GPR, member E 0.681114
MYT1L myelin transcription factor 1-like 0.677522
BRSK2 BR serine/threonine kinase 2 0.677522
SLC22A23 solute carrier family 22, member 23 0.676616
SAMD12 sterile alpha motif domain containing 12 0.675124
ACOXL acyl-CoA oxidase-like 0.675124
MALRD1 MAM and LDL receptor class A domain containing 1 0.674532
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.674238
BEAN1 brain expressed, associated with NEDD4, 1 0.672779
DPCR1 diffuse panbronchiolitis critical region 1 0.671914
PALLD palladin, cytoskeletal associated protein 0.671627
VCAN versican 0.670772
PBX3 pre-B-cell leukemia homeobox 3 0.669923
EXT2 exostosin glycosyltransferase 2 0.669362
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 0.665784
HACD3 3-hydroxyacyl-CoA dehydratase 3 0.66233
KIAA2018 KIAA2018 0.661809
SORCS1 sortilin-related VPS10 domain containing receptor 1 0.661549
EMX2OS EMX2 opposite strand/antisense RNA 0.660775
TSPYL6 TSPY-like 6 0.657736
ZBTB16 zinc finger and BTB domain containing 16 0.65699
RET ret proto-oncogene 0.656496
MATN2 matrilin 2 0.654787
PLA2G4E phospholipase A2, group IVE 0.654545
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 0.653823
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 0.653345
STK39 serine threonine kinase 39 0.652869
TRIM58 tripartite motif containing 58 0.652869
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 0.652631
CAMKMT calmodulin-lysine N-methyltransferase 0.651923
ERG v-ets avian erythroblastosis virus E26 oncogene homolog 0.651688
NXPH2 neurexophilin 2 0.65006
FIP1L1 factor interacting with PAPOLA and CPSF1 0.649139
PRKD1 protein kinase D1 0.649139
CDH13 cadherin 13 0.640562
NRXN3 neurexin 3 0.639391
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.638004
SP4 Sp4 transcription factor 0.63709
ZNF26 zinc finger protein 26 0.636862
SRPRB signal recognition particle receptor, B subunit 0.635508
STARD13 StAR-related lipid transfer (START) domain containing 13 0.63373
C11ORF74 chromosome 11 open reading frame 74 0.63373
ANKRD55 ankyrin repeat domain 55 0.63329
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.633071
MYO3B myosin IIIB 0.631765
COL4A2 collagen, type IV, alpha 2 0.629625
MED12L mediator complex subunit 12-like 0.626496
RNF216 ring finger protein 216 0.625067
DNAH8 dynein, axonemal, heavy chain 8 0.624865
ZNF84 zinc finger protein 84 0.62426
MTMR2 myotubularin related protein 2 0.622467
ITGA1 integrin, alpha 1 0.622467
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 0.62168
LPP LIM domain containing preferred translocation partner in lipoma 0.620511
SPACA3 sperm acrosome associated 3 0.620318
ZNF891 zinc finger protein 891 0.620125
AKAP13 A kinase (PRKA) anchor protein 13 0.619356
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.618783
RAP1GAP2 RAP1 GTPase activating protein 2 0.618783
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.617271
DNAH9 dynein, axonemal, heavy chain 9 0.614969
CSMD1 CUB and Sushi multiple domains 1 0.614779
SHISA9 shisa family member 9 0.613833
CR2 complement component (3d/Epstein Barr virus) receptor 2 0.612151
MARCH10 membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase 0.611781
PRKG2 protein kinase, cGMP-dependent, type II 0.610862
SYK spleen tyrosine kinase 0.610497
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.610315
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.609589
MEF2BNB-MEF2B MEF2BNB-MEF2B readthrough 0.609408
SGSH N-sulfoglucosamine sulfohydrolase 0.60709
LOC644838 uncharacterized LOC644838 0.605862
MECOM MDS1 and EVI1 complex locus 0.60465
CCDC59 coiled-coil domain containing 59 0.604478
MYO10 myosin X 0.604306
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.603622
GALNS galactosamine (N-acetyl)-6-sulfatase 0.603452
FRMD4B FERM domain containing 4B 0.603282
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 0.602268
MCM10 minichromosome maintenance complex component 10 0.600931
WDR7 WD repeat domain 7 0.599285
NCKAP5 NCK-associated protein 5 0.596707
DOCK5 dedicator of cytokinesis 5 0.596548
ASTN2 astrotactin 2 0.596389
TSHZ2 teashirt zinc finger homeobox 2 0.594972
EXOC5 exocyst complex component 5 0.594038
FAM81B family with sequence similarity 81, member B 0.594038
GAPVD1 GTPase activating protein and VPS9 domains 1 0.594038
ZNRF3 zinc and ring finger 3 0.592807
ADAM19 ADAM metallopeptidase domain 19 0.592197
UTRN utrophin 0.591893
PARK2 parkin RBR E3 ubiquitin protein ligase 0.59159
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.591289
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.591138
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.588613
ZFR2 zinc finger RNA binding protein 2 0.587592
ANK2 ankyrin 2, neuronal 0.586438
FAM19A5 family with sequence similarity 19 (chemokine (C-C motif)-like), member A5 0.585756
RAB3C RAB3C, member RAS oncogene family 0.584643
PEX5L peroxisomal biogenesis factor 5-like 0.584397
GPATCH2 G patch domain containing 2 0.58403
STRADA STE20-related kinase adaptor alpha 0.582458
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 0.582099
PHACTR2 phosphatase and actin regulator 2 0.581623
DOCK1 dedicator of cytokinesis 1 0.581623
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.581268
KALRN kalirin, RhoGEF kinase 0.581031
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.580444
METTL25 methyltransferase like 25 0.579976
SLC38A3 solute carrier family 38, member 3 0.579744
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.578589
CREB5 cAMP responsive element binding protein 5 0.578246
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.57745
GLRA3 glycine receptor, alpha 3 0.576886
SHB Src homology 2 domain containing adaptor protein B 0.576774
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 0.575991
ESRRB estrogen-related receptor beta 0.57588
TRAF1 TNF receptor-associated factor 1 0.573469
WSCD2 WSC domain containing 2 0.572823
NIPBL Nipped-B homolog (Drosophila) 0.571756
PDILT protein disulfide isomerase-like, testis expressed 0.571756
ERCC6L2 excision repair cross-complementation group 6-like 2 0.545725
FAM76B family with sequence similarity 76, member B 0.545725
C5ORF42 chromosome 5 open reading frame 42 0.524758
CEP57 centrosomal protein 57kDa 0.522995
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.500023
M6PR mannose-6-phosphate receptor (cation dependent) 0.498792
ZNF45 zinc finger protein 45 0.468945
CSMD3 CUB and Sushi multiple domains 3 0.463649
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.432155
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.408206
CLEC12B C-type lectin domain family 12, member B 0.406588
THRB thyroid hormone receptor, beta 0.40409
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.403073
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.401651
DSCAM Down syndrome cell adhesion molecule 0.400734
TMEM233 transmembrane protein 233 0.400089
SNX29 sorting nexin 29 0.396719
DRD2 dopamine receptor D2 0.395833