hydrochlorothiazide-4970 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the hydrochlorothiazide-4970 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGO4 argonaute RISC catalytic component 4
AJAP1 adherens junctions associated protein 1
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARNT aryl hydrocarbon receptor nuclear translocator
ARTN artemin
BIN1 bridging integrator 1
C11ORF63 chromosome 11 open reading frame 63
CABIN1 calcineurin binding protein 1
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CARF calcium responsive transcription factor
CASKIN2 CASK interacting protein 2
CCNO cyclin O
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CFAP69 cilia and flagella associated protein 69
COL8A2 collagen, type VIII, alpha 2
CSF1R colony stimulating factor 1 receptor
CTSF cathepsin F
CXCR4 chemokine (C-X-C motif) receptor 4
DMPK dystrophia myotonica-protein kinase
DPY19L1P1 DPY19L1 pseudogene 1
EDNRB endothelin receptor type B
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2
EIF5A2 eukaryotic translation initiation factor 5A2
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPHB3 EPH receptor B3
EPOR erythropoietin receptor
ERCC6 excision repair cross-complementation group 6
FABP3 fatty acid binding protein 3, muscle and heart
FAM198B family with sequence similarity 198, member B
FKBP10 FK506 binding protein 10, 65 kDa
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GAB1 GRB2-associated binding protein 1
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GJB3 gap junction protein, beta 3, 31kDa
GLRX glutaredoxin (thioltransferase)
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPC1 glypican 1
GPR153 G protein-coupled receptor 153
GPR27 G protein-coupled receptor 27
GYPB glycophorin B (MNS blood group)
HFE hemochromatosis
HIPK3 homeodomain interacting protein kinase 3
HMGN5 high mobility group nucleosome binding domain 5
HOMER3 homer scaffolding protein 3
ING4 inhibitor of growth family, member 4
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA1109 KIAA1109
KLHL25 kelch-like family member 25
LARP6 La ribonucleoprotein domain family, member 6
LRP6 low density lipoprotein receptor-related protein 6
MAP2K7 mitogen-activated protein kinase kinase 7
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NMT2 N-myristoyltransferase 2
NNAT neuronatin
NOP16 NOP16 nucleolar protein
NR4A1 nuclear receptor subfamily 4, group A, member 1
OGFR opioid growth factor receptor
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PGR progesterone receptor
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKNOX1 PBX/knotted 1 homeobox 1
PKNOX2 PBX/knotted 1 homeobox 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCG1 phospholipase C, gamma 1
POU2F2 POU class 2 homeobox 2
PRB1 proline-rich protein BstNI subfamily 1
PTAFR platelet-activating factor receptor
RAD23B RAD23 homolog B (S. cerevisiae)
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RARA retinoic acid receptor, alpha
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBM5 RNA binding motif protein 5
RIMS3 regulating synaptic membrane exocytosis 3
RNF122 ring finger protein 122
RPL35A ribosomal protein L35a
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCAPER S-phase cyclin A-associated protein in the ER
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SPARCL1 SPARC-like 1 (hevin)
SPTBN5 spectrin, beta, non-erythrocytic 5
TBCD tubulin folding cofactor D
TBRG4 transforming growth factor beta regulator 4
TIMP3 TIMP metallopeptidase inhibitor 3
TLR5 toll-like receptor 5
TRIM36 tripartite motif containing 36
TTC9 tetratricopeptide repeat domain 9
UBE2J1 ubiquitin-conjugating enzyme E2, J1
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1
WWP2 WW domain containing E3 ubiquitin protein ligase 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF230 zinc finger protein 230
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ABHD14A abhydrolase domain containing 14A
ABLIM3 actin binding LIM protein family, member 3
AGMAT agmatine ureohydrolase (agmatinase)
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARMC6 armadillo repeat containing 6
BFSP1 beaded filament structural protein 1, filensin
BIRC3 baculoviral IAP repeat containing 3
C19ORF73 chromosome 19 open reading frame 73
C1ORF115 chromosome 1 open reading frame 115
C5AR2 complement component 5a receptor 2
CA11 carbonic anhydrase XI
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC132 coiled-coil domain containing 132
CD34 CD34 molecule
CIC capicua transcriptional repressor
CLCN2 chloride channel, voltage-sensitive 2
CXADR coxsackie virus and adenovirus receptor
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DRD1 dopamine receptor D1
EFCAB2 EF-hand calcium binding domain 2
EFNA3 ephrin-A3
ETNK2 ethanolamine kinase 2
EXO5 exonuclease 5
FBRS fibrosin
FBXL15 F-box and leucine-rich repeat protein 15
FBXO22 F-box protein 22
FBXO4 F-box protein 4
FGD1 FYVE, RhoGEF and PH domain containing 1
FOXN2 forkhead box N2
GADD45G growth arrest and DNA-damage-inducible, gamma
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
HIST1H2BC histone cluster 1, H2bc
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC13 homeobox C13
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HYI hydroxypyruvate isomerase (putative)
IDI2-AS1 IDI2 antisense RNA 1
IFI27 interferon, alpha-inducible protein 27
IL4R interleukin 4 receptor
KLF3 Kruppel-like factor 3 (basic)
KLHL12 kelch-like family member 12
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRBOX4 KRAB box domain containing 4
KRT8P12 keratin 8 pseudogene 12
LOXL3 lysyl oxidase-like 3
LRP2 low density lipoprotein receptor-related protein 2
LRP5L low density lipoprotein receptor-related protein 5-like
LRRC20 leucine rich repeat containing 20
LYRM9 LYR motif containing 9
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MVP major vault protein
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NEK11 NIMA-related kinase 11
NKAIN1 Na+/K+ transporting ATPase interacting 1
NXPH4 neurexophilin 4
PAIP2B poly(A) binding protein interacting protein 2B
PGBD5 piggyBac transposable element derived 5
PGP phosphoglycolate phosphatase
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRICKLE3 prickle homolog 3 (Drosophila)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB3A RAB3A, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SKI SKI proto-oncogene
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SLMO1 slowmo homolog 1 (Drosophila)
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
STAG3 stromal antigen 3
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TCTN1 tectonic family member 1
TH tyrosine hydroxylase
TICAM1 toll-like receptor adaptor molecule 1
TMC5 transmembrane channel-like 5
TMEM121 transmembrane protein 121
TMEM212 transmembrane protein 212
TPCN1 two pore segment channel 1
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UCN urocortin
WDR62 WD repeat domain 62
WDR91 WD repeat domain 91
WFDC2 WAP four-disulfide core domain 2
ZNF428 zinc finger protein 428
ZNF639 zinc finger protein 639
ZNF778 zinc finger protein 778
ZNF816 zinc finger protein 816
ZNF862 zinc finger protein 862