hydrastinine-5075 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the hydrastinine-5075 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAK1 AP2 associated kinase 1
ACBD4 acyl-CoA binding domain containing 4
ADAM22 ADAM metallopeptidase domain 22
ALMS1 Alstrom syndrome protein 1
APOA4 apolipoprotein A-IV
ATAD5 ATPase family, AAA domain containing 5
ATN1 atrophin 1
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C22ORF24 chromosome 22 open reading frame 24
CABP2 calcium binding protein 2
CHN2 chimerin 2
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CNGB3 cyclic nucleotide gated channel beta 3
CNTD2 cyclin N-terminal domain containing 2
COMT catechol-O-methyltransferase
DAZL deleted in azoospermia-like
DES desmin
DFNB31 deafness, autosomal recessive 31
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DGKQ diacylglycerol kinase, theta 110kDa
DLX5 distal-less homeobox 5
DMC1 DNA meiotic recombinase 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOCK9 dedicator of cytokinesis 9
DOK4 docking protein 4
DUSP1 dual specificity phosphatase 1
ENG endoglin
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
FAM13C family with sequence similarity 13, member C
FAM49B family with sequence similarity 49, member B
FGF4 fibroblast growth factor 4
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAS1 growth arrest-specific 1
GATA4 GATA binding protein 4
GOLGA8A golgin A8 family, member A
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GRIA3 glutamate receptor, ionotropic, AMPA 3
GSK3A glycogen synthase kinase 3 alpha
HLA-DOA major histocompatibility complex, class II, DO alpha
HNRNPM heterogeneous nuclear ribonucleoprotein M
HOXB2 homeobox B2
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
INS insulin
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KIAA0391 KIAA0391
LDAH lipid droplet associated hydrolase
LDHC lactate dehydrogenase C
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LINC00597 long intergenic non-protein coding RNA 597
LOC284244 uncharacterized LOC284244
LRRC37A3 leucine rich repeat containing 37, member A3
LY6G6C lymphocyte antigen 6 complex, locus G6C
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MPO myeloperoxidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MUC3A mucin 3A, cell surface associated
NAG18 NAG18 mRNA
NEURL1 neuralized E3 ubiquitin protein ligase 1
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NRP2 neuropilin 2
NRXN3 neurexin 3
NUP88 nucleoporin 88kDa
OPRK1 opioid receptor, kappa 1
PALM paralemmin
PCDHA9 protocadherin alpha 9
PDE10A phosphodiesterase 10A
PER1 period circadian clock 1
PID1 phosphotyrosine interaction domain containing 1
PML promyelocytic leukemia
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRKCA protein kinase C, alpha
PROX1 prospero homeobox 1
R3HDM1 R3H domain containing 1
RABGAP1L RAB GTPase activating protein 1-like
RAP1GAP RAP1 GTPase activating protein
RGS12 regulator of G-protein signaling 12
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
S1PR1 sphingosine-1-phosphate receptor 1
SAGE1 sarcoma antigen 1
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SPANXC SPANX family, member C
SPTBN5 spectrin, beta, non-erythrocytic 5
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
TCP11L1 t-complex 11, testis-specific-like 1
TJP3 tight junction protein 3
TNK2 tyrosine kinase, non-receptor, 2
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TSKS testis-specific serine kinase substrate
UBXN1 UBX domain protein 1
WDR62 WD repeat domain 62
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
ANKEF1 ankyrin repeat and EF-hand domain containing 1
ANKFY1 ankyrin repeat and FYVE domain containing 1
ARL15 ADP-ribosylation factor-like 15
ASB7 ankyrin repeat and SOCS box containing 7
BAG4 BCL2-associated athanogene 4
BEX4 brain expressed, X-linked 4
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C21ORF91 chromosome 21 open reading frame 91
CCDC88C coiled-coil domain containing 88C
CEMIP cell migration inducing protein, hyaluronan binding
CEP112 centrosomal protein 112kDa
CFAP69 cilia and flagella associated protein 69
CGREF1 cell growth regulator with EF-hand domain 1
CHM choroideremia (Rab escort protein 1)
CNN1 calponin 1, basic, smooth muscle
CNN2 calponin 2
CSF1R colony stimulating factor 1 receptor
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
EFNA3 ephrin-A3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM204A family with sequence similarity 204, member A
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FAT4 FAT atypical cadherin 4
FKBP5 FK506 binding protein 5
FNTB farnesyltransferase, CAAX box, beta
GAL3ST4 galactose-3-O-sulfotransferase 4
GDAP1 ganglioside induced differentiation associated protein 1
GJC1 gap junction protein, gamma 1, 45kDa
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPR176 G protein-coupled receptor 176
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTF2I general transcription factor IIi
H2AFJ H2A histone family, member J
HIST1H2AM histone cluster 1, H2am
HIST1H2BI histone cluster 1, H2bi
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IFI6 interferon, alpha-inducible protein 6
IKZF5 IKAROS family zinc finger 5 (Pegasus)
ITK IL2-inducible T-cell kinase
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA1456 KIAA1456
KLK6 kallikrein-related peptidase 6
LATS1 large tumor suppressor kinase 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG4 ligase IV, DNA, ATP-dependent
LRRC37A4P leucine rich repeat containing 37, member A4, pseudogene
LTBP2 latent transforming growth factor beta binding protein 2
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAN2C1 mannosidase, alpha, class 2C, member 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
NCS1 neuronal calcium sensor 1
NDP Norrie disease (pseudoglioma)
NPM3 nucleophosmin/nucleoplasmin 3
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
NUS1P3 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) pseudogene 3
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PAX9 paired box 9
PBLD phenazine biosynthesis-like protein domain containing
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PRICKLE3 prickle homolog 3 (Drosophila)
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RNF39 ring finger protein 39
RUSC2 RUN and SH3 domain containing 2
SCAMP5 secretory carrier membrane protein 5
SCD5 stearoyl-CoA desaturase 5
SEC14L2 SEC14-like 2 (S. cerevisiae)
SH2D2A SH2 domain containing 2A
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLC35F6 solute carrier family 35, member F6
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SMAD7 SMAD family member 7
SP1 Sp1 transcription factor
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
THOP1 thimet oligopeptidase 1
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast)
TMEM132A transmembrane protein 132A
TRIM25 tripartite motif containing 25
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TSC22D4 TSC22 domain family, member 4
TSPAN12 tetraspanin 12
TTC31 tetratricopeptide repeat domain 31
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
TWISTNB TWIST neighbor
TWSG1 twisted gastrulation BMP signaling modulator 1
ZBTB44 zinc finger and BTB domain containing 44
ZBTB6 zinc finger and BTB domain containing 6
ZMAT5 zinc finger, matrin-type 5
ZNF134 zinc finger protein 134
ZNF197 zinc finger protein 197
ZNF37BP zinc finger protein 37B, pseudogene
ZNF768 zinc finger protein 768