homatropine-5477 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the homatropine-5477 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM22 ADAM metallopeptidase domain 22
ADORA1 adenosine A1 receptor
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDOB aldolase B, fructose-bisphosphate
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
ARHGAP33 Rho GTPase activating protein 33
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
B9D1 B9 protein domain 1
BAIAP2 BAI1-associated protein 2
BAIAP3 BAI1-associated protein 3
BMP15 bone morphogenetic protein 15
C21ORF2 chromosome 21 open reading frame 2
C5AR1 complement component 5a receptor 1
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CCDC132 coiled-coil domain containing 132
CD47 CD47 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELA2A chymotrypsin-like elastase family, member 2A
CFP complement factor properdin
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CUL4B cullin 4B
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ETV5 ets variant 5
EVI5 ecotropic viral integration site 5
FGFR1 fibroblast growth factor receptor 1
FST follistatin
GEMIN8 gem (nuclear organelle) associated protein 8
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GGT1 gamma-glutamyltransferase 1
GLRX3 glutaredoxin 3
GLS glutaminase
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPR15 G protein-coupled receptor 15
HFE hemochromatosis
HIPK3 homeodomain interacting protein kinase 3
HOXA9 homeobox A9
ITGB4 integrin, beta 4
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KRT2 keratin 2, type II
LAPTM5 lysosomal protein transmembrane 5
LIG4 ligase IV, DNA, ATP-dependent
MAGEA3 melanoma antigen family A3
MAPK13 mitogen-activated protein kinase 13
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARS methionyl-tRNA synthetase
MFGE8 milk fat globule-EGF factor 8 protein
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP3 matrix metallopeptidase 3
NOX1 NADPH oxidase 1
NPY neuropeptide Y
PDZD2 PDZ domain containing 2
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PICALM phosphatidylinositol binding clathrin assembly protein
PLD2 phospholipase D2
PON3 paraoxonase 3
PQBP1 polyglutamine binding protein 1
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PTGDR prostaglandin D2 receptor (DP)
PYGB phosphorylase, glycogen; brain
RAI2 retinoic acid induced 2
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RHEB Ras homolog enriched in brain
RNF6 ring finger protein (C3H2C3 type) 6
RPGR retinitis pigmentosa GTPase regulator
RPL10L ribosomal protein L10-like
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCRN3 secernin 3
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SGK2 serum/glucocorticoid regulated kinase 2
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SOS2 son of sevenless homolog 2 (Drosophila)
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SS18 synovial sarcoma translocation, chromosome 18
STAT5B signal transducer and activator of transcription 5B
STON1 stonin 1
TMEM259 transmembrane protein 259
TMEM63A transmembrane protein 63A
TMPRSS6 transmembrane protease, serine 6
TRIM23 tripartite motif containing 23
TRIM48 tripartite motif containing 48
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBA7 ubiquitin-like modifier activating enzyme 7
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
WDR76 WD repeat domain 76
ZC3H13 zinc finger CCCH-type containing 13
ZMYND8 zinc finger, MYND-type containing 8
ZNF287 zinc finger protein 287
ZNRF4 zinc and ring finger 4

decreased expression

Symbol Name
ALDOC aldolase C, fructose-bisphosphate
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARMC7 armadillo repeat containing 7
ATAD3A ATPase family, AAA domain containing 3A
ATG9A autophagy related 9A
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
C2ORF44 chromosome 2 open reading frame 44
C5 complement component 5
C7ORF43 chromosome 7 open reading frame 43
CCDC94 coiled-coil domain containing 94
CD302 CD302 molecule
CHMP6 charged multivesicular body protein 6
CLDND1 claudin domain containing 1
CLSPN claspin
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRLF1 cytokine receptor-like factor 1
CTNND2 catenin (cadherin-associated protein), delta 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERO1L ERO1-like (S. cerevisiae)
EYA2 EYA transcriptional coactivator and phosphatase 2
F8 coagulation factor VIII, procoagulant component
FAM86C1 family with sequence similarity 86, member C1
FBXL2 F-box and leucine-rich repeat protein 2
FBXO31 F-box protein 31
FCHO1 FCH domain only 1
FGGY FGGY carbohydrate kinase domain containing
FLT4 fms-related tyrosine kinase 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GATA6 GATA binding protein 6
GMEB1 glucocorticoid modulatory element binding protein 1
HIST1H2BJ histone cluster 1, H2bj
HMOX1 heme oxygenase 1
IL15RA interleukin 15 receptor, alpha
INO80D INO80 complex subunit D
INTS9 integrator complex subunit 9
IRF2BP1 interferon regulatory factor 2 binding protein 1
JMJD4 jumonji domain containing 4
KAT2A K(lysine) acetyltransferase 2A
KLK5 kallikrein-related peptidase 5
LNPEP leucyl/cystinyl aminopeptidase
LZTS3 leucine zipper, putative tumor suppressor family member 3
MFSD12 major facilitator superfamily domain containing 12
MITF microphthalmia-associated transcription factor
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NIPAL2 NIPA-like domain containing 2
NPFFR1 neuropeptide FF receptor 1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NPY5R neuropeptide Y receptor Y5
NUP62CL nucleoporin 62kDa C-terminal like
PARPBP PARP1 binding protein
PCSK7 proprotein convertase subtilisin/kexin type 7
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PELI1 pellino E3 ubiquitin protein ligase 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G3 phospholipase A2, group III
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
POMZP3 POM121 and ZP3 fusion
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNH1 ribonuclease/angiogenin inhibitor 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SETMAR SET domain and mariner transposase fusion gene
SGPP1 sphingosine-1-phosphate phosphatase 1
SH2D4A SH2 domain containing 4A
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
SNIP1 Smad nuclear interacting protein 1
SPINK5 serine peptidase inhibitor, Kazal type 5
STBD1 starch binding domain 1
STX1A syntaxin 1A (brain)
TBX19 T-box 19
TESC tescalcin
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TMEM115 transmembrane protein 115
TMEM159 transmembrane protein 159
TMEM183A transmembrane protein 183A
TMEM53 transmembrane protein 53
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC23 tetratricopeptide repeat domain 23
TWF2 twinfilin actin binding protein 2
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZNF34 zinc finger protein 34
ZNF442 zinc finger protein 442
ZNF639 zinc finger protein 639
ZNF696 zinc finger protein 696
ZNF747 zinc finger protein 747
ZSCAN26 zinc finger and SCAN domain containing 26