high-density lipoprotein particle Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process. (Gene Ontology, GO_0034364)
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121 proteins co-occuring with the high-density lipoprotein particle cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
LPA lipoprotein, Lp(a) 3.92287
APOA1 apolipoprotein A-I 3.49438
APOA2 apolipoprotein A-II 3.30458
LCAT lecithin-cholesterol acyltransferase 2.95705
CETP cholesteryl ester transfer protein, plasma 2.80868
APOB apolipoprotein B 2.61726
PLTP phospholipid transfer protein 2.40009
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 2.39187
APOE apolipoprotein E 2.38042
LPL lipoprotein lipase 2.07724
PON1 paraoxonase 1 1.85731
SCARB1 scavenger receptor class B, member 1 1.79707
APOC3 apolipoprotein C-III 1.75211
COG2 component of oligomeric golgi complex 2 1.73561
SPINK5 serine peptidase inhibitor, Kazal type 5 1.73184
LIPG lipase, endothelial 1.68177
LIPC lipase, hepatic 1.62886
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 1.49493
APOL1 apolipoprotein L, 1 1.30873
INS insulin 1.24079
SAA1 serum amyloid A1 1.22516
APOM apolipoprotein M 1.1429
APOD apolipoprotein D 1.08222
NAT10 N-acetyltransferase 10 (GCN5-related) 1.07765
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 1.0408
CRP C-reactive protein, pentraxin-related 0.978074
ALB albumin 0.940215
APOA4 apolipoprotein A-IV 0.897646
PON3 paraoxonase 3 0.881477
LDLR low density lipoprotein receptor 0.852502
SHBG sex hormone-binding globulin 0.811652
CXCL14 chemokine (C-X-C motif) ligand 14 0.794229
APOC2 apolipoprotein C-II 0.79148
CMA1 chymase 1, mast cell 0.725705
MYDGF myeloid-derived growth factor 0.698223
APOF apolipoprotein F 0.682027
APOC1 apolipoprotein C-I 0.668559
PLA2G1B phospholipase A2, group IB (pancreas) 0.643144
JPH3 junctophilin 3 0.629892
TGM4 transglutaminase 4 0.626483
SAA2 serum amyloid A2 0.614165
DLL1 delta-like 1 (Drosophila) 0.613318
FAM83H family with sequence similarity 83, member H 0.59896
APOA1BP apolipoprotein A-I binding protein 0.559285
CHD1L chromodomain helicase DNA binding protein 1-like 0.54936
PDZK1 PDZ domain containing 1 0.541117
IGLV1-47 immunoglobulin lambda variable 1-47 0.532898
LBP lipopolysaccharide binding protein 0.519798
MPO myeloperoxidase 0.500664
PON2 paraoxonase 2 0.472412
PCTP phosphatidylcholine transfer protein 0.469203
ZDHHC23 zinc finger, DHHC-type containing 23 0.462798
CLU clusterin 0.459602
COG1 component of oligomeric golgi complex 1 0.448451
ASRGL1 asparaginase like 1 0.424353
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 0.414164
SAA4 serum amyloid A4, constitutive 0.397035
VCAM1 vascular cell adhesion molecule 1 0.367771
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 0.367006
PCOLCE2 procollagen C-endopeptidase enhancer 2 0.365859
HPR haptoglobin-related protein 0.362804
HDLBP high density lipoprotein binding protein 0.35899
PPARA peroxisome proliferator-activated receptor alpha 0.355563
PLA2G12B phospholipase A2, group XIIB 0.354042
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.350243
APOA5 apolipoprotein A-V 0.331719
USF1 upstream transcription factor 1 0.304027
NOS3 nitric oxide synthase 3 (endothelial cell) 0.303655
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.30254
APOH apolipoprotein H (beta-2-glycoprotein I) 0.300682
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 0.29586
POMC proopiomelanocortin 0.295489
DLX3 distal-less homeobox 3 0.291417
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.290308
HMGA2 high mobility group AT-hook 2 0.273
NPC1 Niemann-Pick disease, type C1 0.269701
ICAM1 intercellular adhesion molecule 1 0.26166
HBA1 hemoglobin, alpha 1 0.259109
GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 0.254743
HBA2 hemoglobin, alpha 2 0.253653
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.251476
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 0.24894
APOO apolipoprotein O 0.238119
MBOAT7 membrane bound O-acyltransferase domain containing 7 0.235607
SELE selectin E 0.225267
TF transferrin 0.223143
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 0.218212
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.212974
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.207451
ANGPTL3 angiopoietin-like 3 0.204718
LEP leptin 0.203022
ZNF202 zinc finger protein 202 0.202684
IL6 interleukin 6 0.199993
CTSC cathepsin C 0.196669
FAM65B family with sequence similarity 65, member B 0.181524
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.18093
BGN biglycan 0.179167
SCP2 sterol carrier protein 2 0.175188
NR1H3 nuclear receptor subfamily 1, group H, member 3 0.172468
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.171937
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.169604
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.169099
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 0.16477
APC2 adenomatosis polyposis coli 2 0.161905
LEF1 lymphoid enhancer-binding factor 1 0.160863
C4B complement component 4B (Chido blood group) 0.159268
BPI bactericidal/permeability-increasing protein 0.15776
PLA2G10 phospholipase A2, group X 0.156342
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.142444
OSBPL8 oxysterol binding protein-like 8 0.140143
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.139025
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 0.137947
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.137623
IRF6 interferon regulatory factor 6 0.13597
HDX highly divergent homeobox 0.135938
IGBP1 immunoglobulin (CD79A) binding protein 1 0.13417
TMPRSS15 transmembrane protease, serine 15 0.133233
PHEX phosphate regulating endopeptidase homolog, X-linked 0.131891
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.131633
MSRA methionine sulfoxide reductase A 0.130411
ACACA acetyl-CoA carboxylase alpha 0.12898