hexylcaine-6244 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the hexylcaine-6244 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACYP1 acylphosphatase 1, erythrocyte (common) type
ADAM15 ADAM metallopeptidase domain 15
ADAM17 ADAM metallopeptidase domain 17
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALDOB aldolase B, fructose-bisphosphate
AOX1 aldehyde oxidase 1
APP amyloid beta (A4) precursor protein
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AVL9 AVL9 homolog (S. cerevisiase)
BMP4 bone morphogenetic protein 4
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit
BTD biotinidase
CACTIN cactin, spliceosome C complex subunit
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBX7 chromobox homolog 7
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CORO1B coronin, actin binding protein, 1B
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
EPB41L1 erythrocyte membrane protein band 4.1-like 1
FAM134B family with sequence similarity 134, member B
FGFR2 fibroblast growth factor receptor 2
FXR2 fragile X mental retardation, autosomal homolog 2
GLUL glutamate-ammonia ligase
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPC1 glypican 1
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC11 homeobox C11
IBSP integrin-binding sialoprotein
ICOSLG inducible T-cell co-stimulator ligand
IGL immunoglobulin lambda locus
IL4R interleukin 4 receptor
IL5RA interleukin 5 receptor, alpha
KLC2 kinesin light chain 2
KLF9 Kruppel-like factor 9
LIG4 ligase IV, DNA, ATP-dependent
LINS lines homolog (Drosophila)
LOC730101 uncharacterized LOC730101
LRRC61 leucine rich repeat containing 61
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MET MET proto-oncogene, receptor tyrosine kinase
MID1 midline 1
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MRPS12 mitochondrial ribosomal protein S12
MTMR1 myotubularin related protein 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFE2L3 nuclear factor, erythroid 2-like 3
NOTCH2 notch 2
OGFR opioid growth factor receptor
OVOL1 ovo-like zinc finger 1
PBX2 pre-B-cell leukemia homeobox 2
PCDHGB5 protocadherin gamma subfamily B, 5
PDLIM7 PDZ and LIM domain 7 (enigma)
PGAP1 post-GPI attachment to proteins 1
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PPAP2B phosphatidic acid phosphatase type 2B
PPP5C protein phosphatase 5, catalytic subunit
PSD4 pleckstrin and Sec7 domain containing 4
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RALB v-ral simian leukemia viral oncogene homolog B
RASAL2 RAS protein activator like 2
RCAN1 regulator of calcineurin 1
RUNX1 runt-related transcription factor 1
S100A13 S100 calcium binding protein A13
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SH3BP2 SH3-domain binding protein 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SPRR2B small proline-rich protein 2B
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SSR1 signal sequence receptor, alpha
STX7 syntaxin 7
SUGP1 SURP and G patch domain containing 1
SUGP2 SURP and G patch domain containing 2
TAT tyrosine aminotransferase
TET3 tet methylcytosine dioxygenase 3
TEX261 testis expressed 261
TLE4 transducin-like enhancer of split 4
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM222 transmembrane protein 222
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPMT thiopurine S-methyltransferase
TRAK1 trafficking protein, kinesin binding 1
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VPRBP Vpr (HIV-1) binding protein
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ACTL8 actin-like 8
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANKRD28 ankyrin repeat domain 28
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATAD3A ATPase family, AAA domain containing 3A
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BRAF B-Raf proto-oncogene, serine/threonine kinase
C9ORF91 chromosome 9 open reading frame 91
CA11 carbonic anhydrase XI
CAMTA2 calmodulin binding transcription activator 2
CAPN5 calpain 5
CDKL3 cyclin-dependent kinase-like 3
CENPC centromere protein C
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CIDEC cell death-inducing DFFA-like effector c
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPPED1 calcineurin-like phosphoesterase domain containing 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNM1 dynamin 1
DOCK1 dedicator of cytokinesis 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERCC5 excision repair cross-complementation group 5
ERN2 endoplasmic reticulum to nucleus signaling 2
ETAA1 Ewing tumor-associated antigen 1
EYA2 EYA transcriptional coactivator and phosphatase 2
F8 coagulation factor VIII, procoagulant component
FAM184A family with sequence similarity 184, member A
FBXW12 F-box and WD repeat domain containing 12
FHOD1 formin homology 2 domain containing 1
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H1E histone cluster 1, H1e
IFT22 intraflagellar transport 22
IL15RA interleukin 15 receptor, alpha
IL2 interleukin 2
IRAK4 interleukin-1 receptor-associated kinase 4
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KIAA0895 KIAA0895
KIZ kizuna centrosomal protein
LAMA3 laminin, alpha 3
LRRC49 leucine rich repeat containing 49
LY6G5C lymphocyte antigen 6 complex, locus G5C
LYRM9 LYR motif containing 9
MTMR11 myotubularin related protein 11
MYO1E myosin IE
NDRG4 NDRG family member 4
ORAI3 ORAI calcium release-activated calcium modulator 3
PADI1 peptidyl arginine deiminase, type I
PARG poly (ADP-ribose) glycohydrolase
PDE12 phosphodiesterase 12
PGP phosphoglycolate phosphatase
PILRB paired immunoglobin-like type 2 receptor beta
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRPH peripherin
PRSS16 protease, serine, 16 (thymus)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RGS19 regulator of G-protein signaling 19
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPL13P5 ribosomal protein L13 pseudogene 5
RWDD3 RWD domain containing 3
S100A4 S100 calcium binding protein A4
SCGB2A2 secretoglobin, family 2A, member 2
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SECTM1 secreted and transmembrane 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SMR3A submaxillary gland androgen regulated protein 3A
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYCP2 synaptonemal complex protein 2
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TFF2 trefoil factor 2
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TTC23 tetratricopeptide repeat domain 23
UBXN6 UBX domain protein 6
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VEGFC vascular endothelial growth factor C
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZDHHC14 zinc finger, DHHC-type containing 14
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF219 zinc finger protein 219
ZNF473 zinc finger protein 473
ZNF571 zinc finger protein 571
ZNF586 zinc finger protein 586
ZNF668 zinc finger protein 668
ZNF767P zinc finger family member 767, pseudogene