hepatic steatosis Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description The presence of steatosis in the liver. (Human Phenotype Ontology, HP_0001397)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0001397
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Genes

181 genes associated with the hepatic steatosis phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
PNPLA3 patatin-like phospholipase domain containing 3 2.31699
LOC157273 uncharacterized LOC157273 1.87215
SAMM50 SAMM50 sorting and assembly machinery component 1.67588
PARVB parvin, beta 1.55262
NCAN neurocan 1.50306
COL13A1 collagen, type XIII, alpha 1 1.12851
TP63 tumor protein p63 1.07523
FDFT1 farnesyl-diphosphate farnesyltransferase 1 1.0674
CRACR2A calcium release activated channel regulator 2A 1.05869
EHBP1L1 EH domain binding protein 1-like 1 1.05066
TMEM56-RWDD3 TMEM56-RWDD3 readthrough 1.00059
SLC38A8 solute carrier family 38, member 8 1.00059
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 1.00059
LOC643339 uncharacterized LOC643339 0.969142
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.969142
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 0.969142
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 0.942765
YIPF1 Yip1 domain family, member 1 0.919744
MSRA methionine sulfoxide reductase A 0.896199
DCLK1 doublecortin-like kinase 1 0.882984
MACROD2 MACRO domain containing 2 0.882984
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.882984
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 0.882984
SLC46A3 solute carrier family 46, member 3 0.855449
ARL15 ADP-ribosylation factor-like 15 0.784773
RBMS3 RNA binding motif, single stranded interacting protein 3 0.781779
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 0.706055
SHROOM3 shroom family member 3 0.644641
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.62227
SLC14A2 solute carrier family 14 (urea transporter), member 2 0.62227
CAND1 cullin-associated and neddylation-dissociated 1 0.594349
ZSCAN16 zinc finger and SCAN domain containing 16 0.594349
SCN5A sodium channel, voltage gated, type V alpha subunit 0.594349
SYN3 synapsin III 0.594349
PARK2 parkin RBR E3 ubiquitin protein ligase 0.594349
SASH1 SAM and SH3 domain containing 1 0.594349
ATXN10 ataxin 10 0.594349
MIER2 mesoderm induction early response 1, family member 2 0.593267
SLC44A4 solute carrier family 44, member 4 0.593267
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) 0.593113
JARID2 jumonji, AT rich interactive domain 2 0.591138
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.588175
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.588175
CCDC28A coiled-coil domain containing 28A 0.588029
RCSD1 RCSD domain containing 1 0.587447
SHISA6 shisa family member 6 0.587447
RHOBTB1 Rho-related BTB domain containing 1 0.587447
LOC729950 uncharacterized LOC729950 0.587447
HCG18 HLA complex group 18 (non-protein coding) 0.587447
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.587447
TMEM132D transmembrane protein 132D 0.587447
FFAR4 free fatty acid receptor 4 0.587447
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 0.587303
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.587303
LINC00483 long intergenic non-protein coding RNA 483 0.587303
KAZN kazrin, periplakin interacting protein 0.587303
SDK1 sidekick cell adhesion molecule 1 0.583422
RYR2 ryanodine receptor 2 (cardiac) 0.583422
CRYL1 crystallin, lambda 1 0.582458
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.581386
ZNF212 zinc finger protein 212 0.57928
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.579165
SLC45A1 solute carrier family 45, member 1 0.579165
CGNL1 cingulin-like 1 0.579165
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.579165
CCR6 chemokine (C-C motif) receptor 6 0.579165
SCAPER S-phase cyclin A-associated protein in the ER 0.579165
LOC100132891 0.579165
PDE4D phosphodiesterase 4D, cAMP-specific 0.579165
ZNF282 zinc finger protein 282 0.579165
LINC00511 long intergenic non-protein coding RNA 511 0.579165
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.579165
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.579165
CELF2 CUGBP, Elav-like family member 2 0.579165
DSCAM Down syndrome cell adhesion molecule 0.579165
C4ORF50 chromosome 4 open reading frame 50 0.579165
NTM neurotrimin 0.579165
TRIOBP TRIO and F-actin binding protein 0.579165
GPM6A glycoprotein M6A 0.579165
USP48 ubiquitin specific peptidase 48 0.579165
PDGFC platelet derived growth factor C 0.579165
CNGB1 cyclic nucleotide gated channel beta 1 0.578704
EGFR epidermal growth factor receptor 0.578704
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.578704
ELOVL6 ELOVL fatty acid elongase 6 0.578704
ARHGAP42 Rho GTPase activating protein 42 0.578704
COL19A1 collagen, type XIX, alpha 1 0.578704
TCTN2 tectonic family member 2 0.578704
DRC1 dynein regulatory complex subunit 1 0.578704
UST uronyl-2-sulfotransferase 0.578704
STK19 serine/threonine kinase 19 0.578704
RAB31 RAB31, member RAS oncogene family 0.578704
KLRC1 killer cell lectin-like receptor subfamily C, member 1 0.578704
NUSAP1 nucleolar and spindle associated protein 1 0.578704
ESR1 estrogen receptor 1 0.578704
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.578704
IGF1R insulin-like growth factor 1 receptor 0.578704
PRKCB protein kinase C, beta 0.578704
NCLN nicalin 0.578704
PALLD palladin, cytoskeletal associated protein 0.578704
CER1 cerberus 1, DAN family BMP antagonist 0.578704
LRP1B low density lipoprotein receptor-related protein 1B 0.578704
DIAPH3 diaphanous-related formin 3 0.578704
FLRT3 fibronectin leucine rich transmembrane protein 3 0.578704
DZANK1 double zinc ribbon and ankyrin repeat domains 1 0.578704
MCF2L MCF.2 cell line derived transforming sequence-like 0.578704
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.578704
ADAMTSL4 ADAMTS-like 4 0.578704
BANF2 barrier to autointegration factor 2 0.578704
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.578704
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.578704
ROR2 receptor tyrosine kinase-like orphan receptor 2 0.578704
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 0.578704
SH2D3C SH2 domain containing 3C 0.578704
TTPAL tocopherol (alpha) transfer protein-like 0.578704
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.578704
SBF2 SET binding factor 2 0.578704
NELL1 NEL-like 1 (chicken) 0.578704
EFNA1 ephrin-A1 0.578704
FAN1 FANCD2/FANCI-associated nuclease 1 0.578704
CD48 CD48 molecule 0.577337
EPHA5 EPH receptor A5 0.577224
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.577224
ARID5B AT rich interactive domain 5B (MRF1-like) 0.577224
TJP2 tight junction protein 2 0.577224
LAMC2 laminin, gamma 2 0.577224
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.577224
MYO5C myosin VC 0.576886
C7ORF33 chromosome 7 open reading frame 33 0.576886
TIAM1 T-cell lymphoma invasion and metastasis 1 0.576886
FLJ45831 0.576549
TMEM132B transmembrane protein 132B 0.576549
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.576549
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 0.576437
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.576437
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.576437
LOC100506207 uncharacterized LOC100506207 0.576437
LINC00536 long intergenic non-protein coding RNA 536 0.576437
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.576437
ELAVL2 ELAV like neuron-specific RNA binding protein 2 0.576437
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.576437
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.576437
ACER2 alkaline ceramidase 2 0.576437
ANK2 ankyrin 2, neuronal 0.576437
MIR31HG MIR31 host gene 0.576437
COL4A1 collagen, type IV, alpha 1 0.576437
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 0.576437
LRRC2 leucine rich repeat containing 2 0.576437
FRMD6 FERM domain containing 6 0.576437
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.576437
ZSCAN23 zinc finger and SCAN domain containing 23 0.576437
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.576437
THTPA thiamine triphosphatase 0.576437
HOPX HOP homeobox 0.576437
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 0.576437
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.576437
NALCN sodium leak channel, non selective 0.576437
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.576102
TPRG1 tumor protein p63 regulated 1 0.57588
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B 0.575547
TMEM56 transmembrane protein 56 0.575216
NRG1 neuregulin 1 0.574776
MYOM3 myomesin 3 0.574666
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.574666
NCAM1 neural cell adhesion molecule 1 0.574666
EYS eyes shut homolog (Drosophila) 0.574666
IQGAP1 IQ motif containing GTPase activating protein 1 0.574338
TMEM163 transmembrane protein 163 0.574338
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 0.574338
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.55667
TECRL trans-2,3-enoyl-CoA reductase-like 0.539897
FAM208A family with sequence similarity 208, member A 0.531556
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 0.522995
PLD5 phospholipase D family, member 5 0.522136
GCKR glucokinase (hexokinase 4) regulator 0.508017
CC2D2A coiled-coil and C2 domain containing 2A 0.50668
ATXN7L1 ataxin 7-like 1 0.506024
ZHX2 zinc fingers and homeoboxes 2 0.501459
PTPRG protein tyrosine phosphatase, receptor type, G 0.494506
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 0.475047
RYR3 ryanodine receptor 3 0.441549