heart valve disease Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right). (Human Disease Ontology, DOID_4079)
Similar Terms
Downloads & Tools

Genes

725 genes co-occuring with the disease heart valve disease in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ELN elastin 2.11974
FBN1 fibrillin 1 1.9825
PDLIM1 PDZ and LIM domain 1 1.91453
NPPA natriuretic peptide A 1.78399
OPN3 opsin 3 1.72319
ACE angiotensin I converting enzyme 1.6877
PDZK1IP1 PDZK1 interacting protein 1 1.51018
NOTCH1 notch 1 1.45485
NPPB natriuretic peptide B 1.45089
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.42279
EFS embryonal Fyn-associated substrate 1.41446
CRP C-reactive protein, pentraxin-related 1.3821
VWF von Willebrand factor 1.37381
FBN2 fibrillin 2 1.30226
TNNI3 troponin I type 3 (cardiac) 1.27955
WRNIP1 Werner helicase interacting protein 1 1.2521
AVL9 AVL9 homolog (S. cerevisiase) 1.2356
SPP1 secreted phosphoprotein 1 1.13755
CPB1 carboxypeptidase B1 (tissue) 1.13036
BMP2 bone morphogenetic protein 2 1.12994
JAG1 jagged 1 1.12614
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 1.07572
LECT1 leukocyte cell derived chemotaxin 1 1.07362
TNXB tenascin XB 1.04756
TNXA tenascin XA (pseudogene) 1.03914
GTF2IRD1 GTF2I repeat domain containing 1 1.03704
REN renin 1.0265
GTF2I general transcription factor IIi 1.02608
RUNX2 runt-related transcription factor 2 1.01427
B3GAT3 beta-1,3-glucuronyltransferase 3 1.00963
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein 1.00499
WDR20 WD repeat domain 20 1.00077
DNAH8 dynein, axonemal, heavy chain 8 0.995283
COL5A2 collagen, type V, alpha 2 0.986007
SOS1 son of sevenless homolog 1 (Drosophila) 0.980952
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 0.978006
MMP2 matrix metallopeptidase 2 0.962891
TBX1 T-box 1 0.95369
MGAM maltase-glucoamylase 0.942027
CMA1 chymase 1, mast cell 0.939949
HGD homogentisate 1,2-dioxygenase 0.938289
TNNT2 troponin T type 2 (cardiac) 0.9238
LAX1 lymphocyte transmembrane adaptor 1 0.908553
PLN phospholamban 0.89623
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.895
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 0.889258
GATA4 GATA binding protein 4 0.88475
TBRG1 transforming growth factor beta regulator 1 0.882701
GATA5 GATA binding protein 5 0.879014
MMP9 matrix metallopeptidase 9 0.872462
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 0.872462
LIMK1 LIM domain kinase 1 0.871643
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.869596
ALB albumin 0.866321
DCN decorin 0.835198
MMP1 matrix metallopeptidase 1 0.825768
TGFBR1 transforming growth factor, beta receptor 1 0.821667
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 0.812232
MGP matrix Gla protein 0.811821
TNMD tenomodulin 0.811411
CS citrate synthase 0.806077
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.802385
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 0.796232
TGFB1 transforming growth factor, beta 1 0.787213
F2 coagulation factor II (thrombin) 0.783116
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 0.778204
FUT2 fucosyltransferase 2 (secretor status included) 0.778204
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 0.775341
FLNA filamin A, alpha 0.772479
GJA5 gap junction protein, alpha 5, 40kDa 0.763086
BGN biglycan 0.754527
SPTBN1 spectrin, beta, non-erythrocytic 1 0.753713
PF4 platelet factor 4 0.748017
SH3PXD2B SH3 and PX domains 2B 0.74761
TIMP1 TIMP metallopeptidase inhibitor 1 0.74761
ALPL alkaline phosphatase, liver/bone/kidney 0.746391
ETV3 ets variant 3 0.746391
NOS3 nitric oxide synthase 3 (endothelial cell) 0.74436
ALPPL2 alkaline phosphatase, placental-like 2 0.733811
ALPP alkaline phosphatase, placental 0.733406
OR3A1 olfactory receptor, family 3, subfamily A, member 1 0.728952
BLVRA biliverdin reductase A 0.727738
COL11A1 collagen, type XI, alpha 1 0.727738
PLAT plasminogen activator, tissue 0.727738
FN1 fibronectin 1 0.724907
YME1L1 YME1-like 1 ATPase 0.717232
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 0.714005
C7ORF49 chromosome 7 open reading frame 49 0.713601
HP haptoglobin 0.71078
AHSG alpha-2-HS-glycoprotein 0.708767
ADRB1 adrenoceptor beta 1 0.707961
F3 coagulation factor III (thromboplastin, tissue factor) 0.705144
HPR haptoglobin-related protein 0.70434
EXTL3 exostosin-like glycosyltransferase 3 0.703134
MSTO1 misato 1, mitochondrial distribution and morphology regulator 0.700321
DHDH dihydrodiol dehydrogenase (dimeric) 0.696306
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.694702
PRB3 proline-rich protein BstNI subfamily 3 0.691896
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.688291
EDN1 endothelin 1 0.687491
CALN1 calneuron 1 0.678701
NELFA negative elongation factor complex member A 0.675112
STK25 serine/threonine kinase 25 0.673917
TBX5 T-box 5 0.670333
TRAT1 T cell receptor associated transmembrane adaptor 1 0.66755
HBA2 hemoglobin, alpha 2 0.664372
DUOXA1 dual oxidase maturation factor 1 0.661594
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.658818
MAP2K2 mitogen-activated protein kinase kinase 2 0.656046
CA5B carbonic anhydrase VB, mitochondrial 0.650508
PKD1P6 polycystic kidney disease 1 (autosomal dominant) pseudogene 6 0.650113
FBLN1 fibulin 1 0.649718
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.647743
ACYP1 acylphosphatase 1, erythrocyte (common) type 0.63907
STK3 serine/threonine kinase 3 0.638676
IGLV2-8 immunoglobulin lambda variable 2-8 0.638282
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 0.634349
CNTN3 contactin 3 (plasmacytoma associated) 0.633956
COL3A1 collagen, type III, alpha 1 0.628065
TUBGCP4 tubulin, gamma complex associated protein 4 0.626495
LATS2 large tumor suppressor kinase 2 0.626103
ICAM1 intercellular adhesion molecule 1 0.622967
AGTR1 angiotensin II receptor, type 1 0.621792
IGLV5-48 immunoglobulin lambda variable 5-48 (non-functional) 0.620226
BGLAP bone gamma-carboxyglutamate (gla) protein 0.617486
HBA1 hemoglobin, alpha 1 0.615138
TIMP2 TIMP metallopeptidase inhibitor 2 0.610448
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 0.608494
IGLV9-49 immunoglobulin lambda variable 9-49 0.606152
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.60225
GALNS galactosamine (N-acetyl)-6-sulfatase 0.59913
LDLR low density lipoprotein receptor 0.596012
TNC tenascin C 0.590558
APOB apolipoprotein B 0.58433
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 0.58433
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 0.581996
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 0.581996
IL6 interleukin 6 0.578883
IGLV2-14 immunoglobulin lambda variable 2-14 0.578883
HAND2 heart and neural crest derivatives expressed 2 0.578494
SMAD2 SMAD family member 2 0.578494
SOX9 SRY (sex determining region Y)-box 9 0.576161
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.575772
SLC38A4 solute carrier family 38, member 4 0.572662
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.571884
STK26 serine/threonine protein kinase 26 0.571884
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.5645
COL5A3 collagen, type V, alpha 3 0.563335
IDS iduronate 2-sulfatase 0.562558
MON1A MON1 secretory trafficking family member A 0.562558
THRB thyroid hormone receptor, beta 0.561781
PRAC1 prostate cancer susceptibility candidate 1 0.557897
NPPC natriuretic peptide C 0.556344
ACYP2 acylphosphatase 2, muscle type 0.543542
BMP4 bone morphogenetic protein 4 0.543155
ACP6 acid phosphatase 6, lysophosphatidic 0.542767
SLN sarcolipin 0.542379
RERE arginine-glutamic acid dipeptide (RE) repeats 0.535022
GLS glutaminase 0.533861
PRRC2A proline-rich coiled-coil 2A 0.531541
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.530768
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 0.529222
MYL12B myosin, light chain 12B, regulatory 0.526904
TTN titin 0.526904
MYRF myelin regulatory factor 0.52536
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 0.524202
TIMP4 TIMP metallopeptidase inhibitor 4 0.520346
NF1 neurofibromin 1 0.517649
MDH1 malate dehydrogenase 1, NAD (soluble) 0.51534
LTBP3 latent transforming growth factor beta binding protein 3 0.514956
LUM lumican 0.512264
COX5A cytochrome c oxidase subunit Va 0.508808
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.508424
TPM1 tropomyosin 1 (alpha) 0.502292
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.500761
ADO 2-aminoethanethiol (cysteamine) dioxygenase 0.498849
TNF tumor necrosis factor 0.498467
ADM adrenomedullin 0.493122
F8 coagulation factor VIII, procoagulant component 0.491597
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.490072
PGRMC1 progesterone receptor membrane component 1 0.489311
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 0.487407
PTGDR prostaglandin D2 receptor (DP) 0.487407
DLG3 discs, large homolog 3 (Drosophila) 0.486266
CD68 CD68 molecule 0.483985
VMAC vimentin-type intermediate filament associated coiled-coil protein 0.482844
HRAS Harvey rat sarcoma viral oncogene homolog 0.482464
HOPX HOP homeobox 0.481705
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.479807
DYNLRB1 dynein, light chain, roadblock-type 1 0.479047
LTBP2 latent transforming growth factor beta binding protein 2 0.477909
BAGE2 B melanoma antigen family, member 2 0.477151
GJA1 gap junction protein, alpha 1, 43kDa 0.476772
GIN1 gypsy retrotransposon integrase 1 0.475634
FBLN5 fibulin 5 0.471089
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.465416
TSHR thyroid stimulating hormone receptor 0.464283
F10 coagulation factor X 0.458996
CPLX4 complexin 4 0.458996
COL2A1 collagen, type II, alpha 1 0.458996
TRPS1 trichorhinophalangeal syndrome I 0.457864
SLK STE20-like kinase 0.452962
MVD mevalonate (diphospho) decarboxylase 0.451831
PFKM phosphofructokinase, muscle 0.448817
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.447311
VCAM1 vascular cell adhesion molecule 1 0.446558
MLX MLX, MAX dimerization protein 0.443547
VCAN versican 0.437154
HLA-DOB major histocompatibility complex, class II, DO beta 0.436402
SP7 Sp7 transcription factor 0.433397
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.429266
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.428891
ICK intestinal cell (MAK-like) kinase 0.42739
MAP2K1 mitogen-activated protein kinase kinase 1 0.427015
APOC4 apolipoprotein C-IV 0.427015
VKORC1 vitamin K epoxide reductase complex, subunit 1 0.42589
CD59 CD59 molecule, complement regulatory protein 0.42589
PTCH1 patched 1 0.424389
HIRA histone cell cycle regulator 0.424014
CLTCL1 clathrin, heavy chain-like 1 0.421765
WBSCR22 Williams Beuren syndrome chromosome region 22 0.419892
NSUN5 NOP2/Sun domain family, member 5 0.419142
IRF6 interferon regulatory factor 6 0.412779
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 0.412779
APOE apolipoprotein E 0.406425
PIR pirin (iron-binding nuclear protein) 0.403811
PTER phosphotriesterase related 0.401945
FMOD fibromodulin 0.401199
PTH parathyroid hormone 0.398589
PKN2 protein kinase N2 0.395608
DSE dermatan sulfate epimerase 0.394118
RGS18 regulator of G-protein signaling 18 0.391513
IGLV1-36 immunoglobulin lambda variable 1-36 0.390769
GLS2 glutaminase 2 (liver, mitochondrial) 0.387794
TLR4 toll-like receptor 4 0.384451
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 0.384451
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 0.383337
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 0.381481
ROM1 retinal outer segment membrane protein 1 0.380368
IDUA iduronidase, alpha-L- 0.374068
BCL7B B-cell CLL/lymphoma 7B 0.373698
CA2 carbonic anhydrase II 0.373328
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 0.373328
KIAA0101 KIAA0101 0.372587
APOA1 apolipoprotein A-I 0.372587
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.372217
PHF12 PHD finger protein 12 0.368149
GATA6 GATA binding protein 6 0.36704
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.366301
ESPN espin 0.365562
CTGF connective tissue growth factor 0.364085
MMP3 matrix metallopeptidase 3 0.362609
C1D C1D nuclear receptor corepressor 0.362239
ALYREF Aly/REF export factor 0.359657
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 0.358551
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.357814
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 0.357446
IGF1 insulin-like growth factor 1 (somatomedin C) 0.356709
CD34 CD34 molecule 0.355972
PLAC8 placenta-specific 8 0.353763
CD79A CD79a molecule, immunoglobulin-associated alpha 0.353763
GRB2 growth factor receptor-bound protein 2 0.352291
TBL2 transducin (beta)-like 2 0.348614
PPT1 palmitoyl-protein thioesterase 1 0.347144
SRR serine racemase 0.347144
CTSS cathepsin S 0.342006
PCDH8 protocadherin 8 0.341639
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.337975
MRAP melanocortin 2 receptor accessory protein 0.337975
ENO3 enolase 3 (beta, muscle) 0.334315
COG2 component of oligomeric golgi complex 2 0.333218
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.332852
LRP5 low density lipoprotein receptor-related protein 5 0.332487
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.332121
MPG N-methylpurine-DNA glycosylase 0.332121
CROCC ciliary rootlet coiled-coil, rootletin 0.331025
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.331025
VCX variable charge, X-linked 0.331025
KNG1 kininogen 1 0.330295
ZNF74 zinc finger protein 74 0.3292
IGLV1-47 immunoglobulin lambda variable 1-47 0.328469
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.32774
SIRPA signal-regulatory protein alpha 0.321909
TRIM25 tripartite motif containing 25 0.320817
LSR lipolysis stimulated lipoprotein receptor 0.320454
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.319726
GH2 growth hormone 2 0.319363
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.316819
S100A5 S100 calcium binding protein A5 0.312827
C6ORF25 chromosome 6 open reading frame 25 0.311377
IGLV3-10 immunoglobulin lambda variable 3-10 0.310652
PEX12 peroxisomal biogenesis factor 12 0.31029
VCX2 variable charge, X-linked 2 0.307757
AVPR2 arginine vasopressin receptor 2 0.30631
CKM creatine kinase, muscle 0.304142
VEGFA vascular endothelial growth factor A 0.303059
SMAD3 SMAD family member 3 0.299812
LOX lysyl oxidase 0.299092
TGFB2 transforming growth factor, beta 2 0.297651
KLF10 Kruppel-like factor 10 0.296931
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 0.293694
HPD 4-hydroxyphenylpyruvate dioxygenase 0.289744
MYSM1 Myb-like, SWIRM and MPN domains 1 0.289027
INS insulin 0.287235
MSX2 msh homeobox 2 0.284013
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 0.284013
RFX1 regulatory factor X, 1 (influences HLA class II expression) 0.283655
TGM4 transglutaminase 4 0.281868
FGF1 fibroblast growth factor 1 (acidic) 0.277227
MB myoglobin 0.277227
IBSP integrin-binding sialoprotein 0.277227
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.274732
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.274021
VCX3B variable charge, X-linked 3B 0.274021
S100A9 S100 calcium binding protein A9 0.273664
BANF1 barrier to autointegration factor 1 0.272597
MECOM MDS1 and EVI1 complex locus 0.269398
CCL2 chemokine (C-C motif) ligand 2 0.269043
EVC Ellis van Creveld protein 0.267622
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 0.266913
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.265849
JUN jun proto-oncogene 0.265849
MYH7 myosin, heavy chain 7, cardiac muscle, beta 0.264431
MSX1 msh homeobox 1 0.261245
NEBL nebulette 0.260538
FOXO4 forkhead box O4 0.260184
ACTA2 actin, alpha 2, smooth muscle, aorta 0.257005
RPS2 ribosomal protein S2 0.255594
VCX3A variable charge, X-linked 3A 0.254536
F5 coagulation factor V (proaccelerin, labile factor) 0.253127
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.253127
FAT3 FAT atypical cadherin 3 0.252774
IL10 interleukin 10 0.251366
POU2F3 POU class 2 homeobox 3 0.251015
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.250663
SELE selectin E 0.247501
ZMYM3 zinc finger, MYM-type 3 0.24715
GUSB glucuronidase, beta 0.246799
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.245046
CRCP CGRP receptor component 0.245046
ACKR3 atypical chemokine receptor 3 0.243295
MMP25 matrix metallopeptidase 25 0.242945
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.241196
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.238054
RNF112 ring finger protein 112 0.237357
RCAN1 regulator of calcineurin 1 0.235616
CST3 cystatin C 0.23353
CXCL8 chemokine (C-X-C motif) ligand 8 0.232489
ACOT13 acyl-CoA thioesterase 13 0.230755
CHAT choline O-acetyltransferase 0.230409
EHD1 EH-domain containing 1 0.229024
SNAPIN SNAP-associated protein 0.228679
PRTN3 proteinase 3 0.228679
RFX6 regulatory factor X, 6 0.227642
COL1A2 collagen, type I, alpha 2 0.227297
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.226952
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.224196
MTTP microsomal triglyceride transfer protein 0.223509
CTF1 cardiotrophin 1 0.223165
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.223165
PER3 period circadian clock 3 0.222822
BMP2K BMP2 inducible kinase 0.222136
TLR2 toll-like receptor 2 0.218715
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.218715
KMT2A lysine (K)-specific methyltransferase 2A 0.218034
BAMBI BMP and activin membrane-bound inhibitor 0.217693
CALCA calcitonin-related polypeptide alpha 0.217352
GSR glutathione reductase 0.216332
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.214975
EMILIN1 elastin microfibril interfacer 1 0.214636
JARID2 jumonji, AT rich interactive domain 2 0.214636
APLNR apelin receptor 0.213621
ADORA2A adenosine A2a receptor 0.213283
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.212945
DNTT DNA nucleotidylexotransferase 0.212608
ADSL adenylosuccinate lyase 0.212271
RDX radixin 0.211261
WNT3A wingless-type MMTV integration site family, member 3A 0.209918
XYLT2 xylosyltransferase II 0.209583
NANP N-acetylneuraminic acid phosphatase 0.209583
ERAS ES cell expressed Ras 0.208914
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 0.208579
JPH2 junctophilin 2 0.207578
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.207245
MYOM2 myomesin 2 0.206913
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.205916
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.204923
APOH apolipoprotein H (beta-2-glycoprotein I) 0.204593
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) 0.203275
VARS valyl-tRNA synthetase 0.203275
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.202946
KLF15 Kruppel-like factor 15 0.202618
BBS2 Bardet-Biedl syndrome 2 0.20229
TPH1 tryptophan hydroxylase 1 0.201635
NAAA N-acylethanolamine acid amidase 0.200656
LEFTY1 left-right determination factor 1 0.199681
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) 0.198709
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.198386
STAB2 stabilin 2 0.196779
BCL7A B-cell CLL/lymphoma 7A 0.19582
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.195501
IVD isovaleryl-CoA dehydrogenase 0.194548
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.193915
MMP13 matrix metallopeptidase 13 0.192971
ADCY2 adenylate cyclase 2 (brain) 0.192971
AVP arginine vasopressin 0.188326
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.187113
MAPK3 mitogen-activated protein kinase 3 0.18651
SDF4 stromal cell derived factor 4 0.18591
CCNDBP1 cyclin D-type binding-protein 1 0.18591
COL1A1 collagen, type I, alpha 1 0.185612
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.185313
DSC3 desmocollin 3 0.184128
ASXL1 additional sex combs like transcriptional regulator 1 0.182375
ADRB2 adrenoceptor beta 2, surface 0.181798
RAB27A RAB27A, member RAS oncogene family 0.18151
SRSF2 serine/arginine-rich splicing factor 2 0.180084
LY96 lymphocyte antigen 96 0.177851
TIMP3 TIMP metallopeptidase inhibitor 3 0.177029
SMAD9 SMAD family member 9 0.176757
PON1 paraoxonase 1 0.176485
NPY neuropeptide Y 0.174881
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.174354
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.174093
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.172799
PAAF1 proteasomal ATPase-associated factor 1 0.171785
TTR transthyretin 0.167682
PER1 period circadian clock 1 0.166544
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.166095
CT45A1 cancer/testis antigen family 45, member A1 0.165217
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.164786
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 0.164571
CTSV cathepsin V 0.164149
CASQ2 calsequestrin 2 (cardiac muscle) 0.163938
HLA-B major histocompatibility complex, class I, B 0.163729
MAPT microtubule-associated protein tau 0.163523
OGN osteoglycin 0.163111
ACTN1 actinin, alpha 1 0.161912
FBL fibrillarin 0.160761
ZIC3 Zic family member 3 0.159838
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.158266
NOX4 NADPH oxidase 4 0.158097
KLHL17 kelch-like family member 17 0.138476
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.137918
MAP9 microtubule-associated protein 9 0.137273
HES5 hes family bHLH transcription factor 5 0.13634
SRI sorcin 0.136206
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 0.135646
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.135324
LACTB lactamase, beta 0.134056
LY6E lymphocyte antigen 6 complex, locus E 0.13367
SLC30A2 solute carrier family 30 (zinc transporter), member 2 0.132691
NKX2-5 NK2 homeobox 5 0.131599
TBX2 T-box 2 0.131479
BIN2 bridging integrator 2 0.130114
AUTS2 autism susceptibility candidate 2 0.129526
AURKAIP1 aurora kinase A interacting protein 1 0.128647
BMPR1A bone morphogenetic protein receptor, type IA 0.128324
RER1 retention in endoplasmic reticulum sorting receptor 1 0.127448
LEMD3 LEM domain containing 3 0.127113
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.126564
CDK11A cyclin-dependent kinase 11A 0.126431
RBM41 RNA binding motif protein 41 0.125952
OXTR oxytocin receptor 0.125386
HMGA2 high mobility group AT-hook 2 0.124968
ATF2 activating transcription factor 2 0.124303
GAB1 GRB2-associated binding protein 1 0.123981
ELOVL6 ELOVL fatty acid elongase 6 0.123815
LIMS1 LIM and senescent cell antigen-like domains 1 0.123427
THBD thrombomodulin 0.122628
CNTN4 contactin 4 0.122525
EFNA5 ephrin-A5 0.122464
UTS2 urotensin 2 0.122282
AMT aminomethyltransferase 0.121968
ZFPM2 zinc finger protein, FOG family member 2 0.121887
RING1 ring finger protein 1 0.121106
FXYD1 FXYD domain containing ion transport regulator 1 0.120966
ADD3 adducin 3 (gamma) 0.120053
GGCX gamma-glutamyl carboxylase 0.119687
HAND1 heart and neural crest derivatives expressed 1 0.119288
PTF1A pancreas specific transcription factor, 1a 0.117826
MINK1 misshapen-like kinase 1 0.117421
PTCH2 patched 2 0.117224
SPRED1 sprouty-related, EVH1 domain containing 1 0.1169
CLIC1 chloride intracellular channel 1 0.116697
EDN3 endothelin 3 0.116685
PLIN1 perilipin 1 0.116471
INSC inscuteable homolog (Drosophila) 0.116184
DCPS decapping enzyme, scavenger 0.115244
CTAG2 cancer/testis antigen 2 0.115027
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.114691
COL5A1 collagen, type V, alpha 1 0.114431
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.114071
PRIMA1 proline rich membrane anchor 1 0.112429
IL31RA interleukin 31 receptor A 0.11235
HIP1 huntingtin interacting protein 1 0.112311
CXCL6 chemokine (C-X-C motif) ligand 6 0.112311
INVS inversin 0.112258
CKB creatine kinase, brain 0.112192
GPR182 G protein-coupled receptor 182 0.112139
HLA-E major histocompatibility complex, class I, E 0.111723
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 0.11171
PICALM phosphatidylinositol binding clathrin assembly protein 0.111072
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.110822
MAP6 microtubule-associated protein 6 0.11064
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 0.110445
ARR3 arrestin 3, retinal (X-arrestin) 0.110417
NOTO notochord homeobox 0.110361
TBX3 T-box 3 0.11018
ANGPT2 angiopoietin 2 0.109938
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 0.109852
KRAS Kirsten rat sarcoma viral oncogene homolog 0.109809
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 0.109795
FLT4 fms-related tyrosine kinase 4 0.109737
BCO1 beta-carotene oxygenase 1 0.109579
FMN1 formin 1 0.109565
COL6A2 collagen, type VI, alpha 2 0.10912
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.108618
GRHL1 grainyhead-like 1 (Drosophila) 0.108471
ONECUT3 one cut homeobox 3 0.108338
MT-ATP8 ATP synthase F0 subunit 8 0.108176
GLG1 golgi glycoprotein 1 0.108102
TTC34 tetratricopeptide repeat domain 34 0.108012
HLA-DMA major histocompatibility complex, class II, DM alpha 0.107739
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.107496
CYGB cytoglobin 0.106996
SPATA5 spermatogenesis associated 5 0.106715
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 0.106014
ZNF185 zinc finger protein 185 (LIM domain) 0.105664
PMM2 phosphomannomutase 2 0.10552
CSPG4 chondroitin sulfate proteoglycan 4 0.10512
UBAP1 ubiquitin associated protein 1 0.105024
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.10496
LINGO1 leucine rich repeat and Ig domain containing 1 0.10439
KRT84 keratin 84, type II 0.104078
LDHA lactate dehydrogenase A 0.104078
PHB2 prohibitin 2 0.10398
RAD23B RAD23 homolog B (S. cerevisiae) 0.103783
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.103484
KLK15 kallikrein-related peptidase 15 0.103181
IL17C interleukin 17C 0.103046
HSPB8 heat shock 22kDa protein 8 0.102811
SCN5A sodium channel, voltage gated, type V alpha subunit 0.102727
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.101888
COL18A1 collagen, type XVIII, alpha 1 0.101819
POLB polymerase (DNA directed), beta 0.101716
PRAMEF6 PRAME family member 6 0.101716
USO1 USO1 vesicle transport factor 0.101578
NOVA2 neuro-oncological ventral antigen 2 0.101544
DKK3 dickkopf WNT signaling pathway inhibitor 3 0.101527
IGFBP3 insulin-like growth factor binding protein 3 0.101492
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.101441
JAG2 jagged 2 0.10132
TPTE transmembrane phosphatase with tensin homology 0.101127
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.101109
PLTP phospholipid transfer protein 0.100809
ZFYVE9 zinc finger, FYVE domain containing 9 0.100721
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 0.100615
DLX5 distal-less homeobox 5 0.100562
MUS81 MUS81 structure-specific endonuclease subunit 0.100527
ATP2A3 ATPase, Ca++ transporting, ubiquitous 0.100527
FBLL1 fibrillarin-like 1 0.100333
C1ORF174 chromosome 1 open reading frame 174 0.100245
CORIN corin, serine peptidase 0.100175
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 0.099997
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.099925
TBX20 T-box 20 0.099925
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.099853
LIN7A lin-7 homolog A (C. elegans) 0.099708
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 0.0996
PEPD peptidase D 0.0996
DCT dopachrome tautomerase 0.099492
TXNIP thioredoxin interacting protein 0.099095
AK2 adenylate kinase 2 0.098987
SFRP2 secreted frizzled-related protein 2 0.098879
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.098843
ANXA7 annexin A7 0.098789
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 0.09877
CAPN2 calpain 2, (m/II) large subunit 0.098475
FAM131C family with sequence similarity 131, member C 0.098475
WIPF2 WAS/WASL interacting protein family, member 2 0.098456
HTN3 histatin 3 0.098272
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.098216
ANO1 anoctamin 1, calcium activated chloride channel 0.098216
AMD1 adenosylmethionine decarboxylase 1 0.098069
CXCL16 chemokine (C-X-C motif) ligand 16 0.097977
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.097719
RRM2 ribonucleotide reductase M2 0.09746
RYR2 ryanodine receptor 2 (cardiac) 0.097384
FOXC1 forkhead box C1 0.096367
LDHC lactate dehydrogenase C 0.09616
BMF Bcl2 modifying factor 0.095852
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.095852
IL1RL1 interleukin 1 receptor-like 1 0.09566
CYLD cylindromatosis (turban tumor syndrome) 0.095525
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 0.095371
IFI44 interferon-induced protein 44 0.095218
FBLN2 fibulin 2 0.094735
BCL9 B-cell CLL/lymphoma 9 0.094696
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 0.094206
TKT transketolase 0.094147
NCBP1 nuclear cap binding protein subunit 1, 80kDa 0.094147
TAS1R1 taste receptor, type 1, member 1 0.094069
MYBPC3 myosin binding protein C, cardiac 0.09403
POR P450 (cytochrome) oxidoreductase 0.093853
RSPO1 R-spondin 1 0.093834
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.093618
PLG plasminogen 0.093599
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.09356
PNKD paroxysmal nonkinesigenic dyskinesia 0.093521
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.093421
A1BG alpha-1-B glycoprotein 0.093401
TMEM245 transmembrane protein 245 0.092043
PERP PERP, TP53 apoptosis effector 0.091799
MYO7A myosin VIIA 0.091677
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.091656
ACVRL1 activin A receptor type II-like 1 0.090965
AGER advanced glycosylation end product-specific receptor 0.090803
LPA lipoprotein, Lp(a) 0.090329
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.090247
PTPRF protein tyrosine phosphatase, receptor type, F 0.09004
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.089379
PEX10 peroxisomal biogenesis factor 10 0.089338
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.089338
CUTA cutA divalent cation tolerance homolog (E. coli) 0.089192
ADORA2B adenosine A2b receptor 0.088898
FOS FBJ murine osteosarcoma viral oncogene homolog 0.08706
EPHA2 EPH receptor A2 0.087038
MAPK9 mitogen-activated protein kinase 9 0.086932
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.086506
KCNK2 potassium channel, two pore domain subfamily K, member 2 0.086293
SALL1 spalt-like transcription factor 1 0.086054
AXL AXL receptor tyrosine kinase 0.08599
OSCAR osteoclast associated, immunoglobulin-like receptor 0.085405
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 0.083945
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.083089
PROM1 prominin 1 0.082134
AATF apoptosis antagonizing transcription factor 0.082112
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.081578
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.081421
MLXIPL MLX interacting protein-like 0.081353
ADRBK1 adrenergic, beta, receptor kinase 1 0.079983
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.079166
RHOF ras homolog family member F (in filopodia) 0.07912
NOS1 nitric oxide synthase 1 (neuronal) 0.078667
GYPA glycophorin A (MNS blood group) 0.078462
NPR3 natriuretic peptide receptor 3 0.07766
MMD monocyte to macrophage differentiation-associated 0.077042
GP2 glycoprotein 2 (zymogen granule membrane) 0.076465
MEFV Mediterranean fever 0.075564
ACVR1 activin A receptor, type I 0.074472
MASP2 mannan-binding lectin serine peptidase 2 0.073634
FTL ferritin, light polypeptide 0.073399
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.073399
FTH1 ferritin, heavy polypeptide 1 0.073399
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.07286
MRI1 methylthioribose-1-phosphate isomerase 1 0.07272
MARS methionyl-tRNA synthetase 0.072673
FGFR1 fibroblast growth factor receptor 1 0.072416
LMNA lamin A/C 0.072228
DYNLT1 dynein, light chain, Tctex-type 1 0.071004
CA8 carbonic anhydrase VIII 0.070839
IGLL5 immunoglobulin lambda-like polypeptide 5 0.070839
TCN2 transcobalamin II 0.070721
MIXL1 Mix paired-like homeobox 0.070368
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.070083
FGB fibrinogen beta chain 0.069823
POMT2 protein-O-mannosyltransferase 2 0.069728
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa 0.069373
SCG5 secretogranin V 0.069326
TOB1 transducer of ERBB2, 1 0.069302
FAT1 FAT atypical cadherin 1 0.069184
BCHE butyrylcholinesterase 0.069042
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 0.068972
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 0.06883
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 0.068806
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.068473
KLF6 Kruppel-like factor 6 0.067974
AAAS achalasia, adrenocortical insufficiency, alacrimia 0.067832
EVL Enah/Vasp-like 0.067832
MTDH metadherin 0.066477
PCSK9 proprotein convertase subtilisin/kexin type 9 0.066334
GPANK1 G patch domain and ankyrin repeats 1 0.06631
TBK1 TANK-binding kinase 1 0.066143
CLEC3B C-type lectin domain family 3, member B 0.065929
WNT3 wingless-type MMTV integration site family, member 3 0.065882
ACTC1 actin, alpha, cardiac muscle 1 0.065834
PTK2 protein tyrosine kinase 2 0.065691
THBS4 thrombospondin 4 0.06562
UST uronyl-2-sulfotransferase 0.065596
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 0.065334
PDS5B PDS5 cohesin associated factor B 0.065024
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 0.064928
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.06469
SST somatostatin 0.064547
HAPLN1 hyaluronan and proteoglycan link protein 1 0.064499
INA internexin neuronal intermediate filament protein, alpha 0.064451
POMT1 protein-O-mannosyltransferase 1 0.064428
VAV1 vav 1 guanine nucleotide exchange factor 0.06438
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.064356
RRM1 ribonucleotide reductase M1 0.064213
DAND5 DAN domain family member 5, BMP antagonist 0.064189
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.064094
PHGDH phosphoglycerate dehydrogenase 0.063999
TERF2 telomeric repeat binding factor 2 0.063928
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.06388
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.063761
CHGA chromogranin A 0.063522
MCAM melanoma cell adhesion molecule 0.063474
FLT1 fms-related tyrosine kinase 1 0.063474
CABIN1 calcineurin binding protein 1 0.063355
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 0.063355
HYAL1 hyaluronoglucosaminidase 1 0.063331
ADAM17 ADAM metallopeptidase domain 17 0.063331
GDF15 growth differentiation factor 15 0.063211
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.063188
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.062854
VCP valosin containing protein 0.062544
WEE1 WEE1 G2 checkpoint kinase 0.062472
JUNB jun B proto-oncogene 0.062353
GJC1 gap junction protein, gamma 1, 45kDa 0.062329
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.062067
TRIM21 tripartite motif containing 21 0.062043
NPC1L1 NPC1-like 1 0.061852
IL18 interleukin 18 0.061805