hearing impairment Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A decreased magnitude of the sensory perception of sound. (Human Phenotype Ontology, HP_0000365)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0000365
Similar Terms
Downloads & Tools

Genes

137 genes associated with the hearing impairment phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
PKNOX2 PBX/knotted 1 homeobox 2 1.114
PTPRD protein tyrosine phosphatase, receptor type, D 1.10714
IQGAP2 IQ motif containing GTPase activating protein 2 1.09906
PDE9A phosphodiesterase 9A 1.08514
DTD1 D-tyrosyl-tRNA deacylase 1 1.05335
CMIP c-Maf inducing protein 1.04605
PTPRK protein tyrosine phosphatase, receptor type, K 1.00059
EPAS1 endothelial PAS domain protein 1 0.994211
PRCP prolylcarboxypeptidase (angiotensinase C) 0.993873
YAP1 Yes-associated protein 1 0.993537
KLHL25 kelch-like family member 25 0.978536
MMP8 matrix metallopeptidase 8 0.959521
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.959521
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 0.956697
SLCO6A1 solute carrier organic anion transporter family, member 6A1 0.945598
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.944405
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.933903
FMN1 formin 1 0.932707
PTPRG protein tyrosine phosphatase, receptor type, G 0.930595
RIMBP2 RIMS binding protein 2 0.924992
QRFPR pyroglutamylated RFamide peptide receptor 0.922853
COMMD10 COMM domain containing 10 0.919947
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.917141
DIAPH3 diaphanous-related formin 3 0.916944
LOC284379 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 pseudogene 0.91336
TACC2 transforming, acidic coiled-coil containing protein 2 0.91294
LUZP2 leucine zipper protein 2 0.904931
FGF14 fibroblast growth factor 14 0.904359
SALL3 spalt-like transcription factor 3 0.898656
KIAA0895 KIAA0895 0.897947
PCDH15 protocadherin-related 15 0.89067
ANGPT4 angiopoietin 4 0.890162
CLSTN2 calsyntenin 2 0.887255
ALPK2 alpha-kinase 2 0.877992
PIBF1 progesterone immunomodulatory binding factor 1 0.872981
KRT82 keratin 82, type II 0.862169
MFSD1 major facilitator superfamily domain containing 1 0.858869
UBE2Q2P1 ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 1 0.854378
PARK2 parkin RBR E3 ubiquitin protein ligase 0.850449
LOC100129620 uncharacterized LOC100129620 0.847125
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 0.846908
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.844874
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.828922
KIF26B kinesin family member 26B 0.778885
LRRN1 leucine rich repeat neuronal 1 0.771265
MSRA methionine sulfoxide reductase A 0.753299
CSMD1 CUB and Sushi multiple domains 1 0.753299
PLCE1 phospholipase C, epsilon 1 0.741936
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 0.712886
WDR33 WD repeat domain 33 0.709765
ZNF496 zinc finger protein 496 0.709012
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.704969
GPHN gephyrin 0.701084
LOC100287944 uncharacterized LOC100287944 0.691208
ZNF146 zinc finger protein 146 0.687825
FLJ45872 0.683684
PEX14 peroxisomal biogenesis factor 14 0.674238
TMEM135 transmembrane protein 135 0.662069
PTPRT protein tyrosine phosphatase, receptor type, T 0.661032
CD209 CD209 molecule 0.64787
EFNA5 ephrin-A5 0.62629
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.621876
LMO7 LIM domain 7 0.619547
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.618593
GPR155 G protein-coupled receptor 155 0.609951
FGD4 FYVE, RhoGEF and PH domain containing 4 0.605515
ASXL2 additional sex combs like transcriptional regulator 2 0.599285
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.593421
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 0.579396
FOXP1 forkhead box P1 0.578589
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.577224
LINC00486 long intergenic non-protein coding RNA 486 0.573469
C1ORF87 chromosome 1 open reading frame 87 0.568635
STIM2 stromal interaction molecule 2 0.56762
FRMD4A FERM domain containing 4A 0.565624
TP63 tumor protein p63 0.563675
LOC100507462 uncharacterized LOC100507462 0.562717
CREB5 cAMP responsive element binding protein 5 0.554715
REN renin 0.552815
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 0.546287
TENM1 teneurin transmembrane protein 1 0.539082
KISS1 KiSS-1 metastasis-suppressor 0.537883
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.537883
TMEM260 transmembrane protein 260 0.535562
TSPAN9 tetraspanin 9 0.535185
MYOM2 myomesin 2 0.53407
CHN2 chimerin 2 0.532978
AIRE autoimmune regulator 0.53086
COL23A1 collagen, type XXIII, alpha 1 0.530515
CADPS Ca++-dependent secretion activator 0.529494
LGMN legumain 0.528492
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.524164
PDZD8 PDZ domain containing 8 0.521292
STK3 serine/threonine kinase 3 0.520736
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.520461
TTLL11 tubulin tyrosine ligase-like family member 11 0.519375
PRMT3 protein arginine methyltransferase 3 0.51884
DMD dystrophin 0.518312
EGFEM1P EGF-like and EMI domain containing 1, pseudogene 0.518312
TNIK TRAF2 and NCK interacting kinase 0.518312
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.518312
TRIM23 tripartite motif containing 23 0.518049
NUB1 negative regulator of ubiquitin-like proteins 1 0.517529
TGFB2 transforming growth factor, beta 2 0.517529
T T, brachyury homolog (mouse) 0.517271
CHL1 cell adhesion molecule L1-like 0.5155
GTPBP8 GTP-binding protein 8 (putative) 0.5155
KCNK9 potassium channel, two pore domain subfamily K, member 9 0.513244
ACSS1 acyl-CoA synthetase short-chain family member 1 0.512746
KIN Kin17 DNA and RNA binding protein 0.510564
GRID2 glutamate receptor, ionotropic, delta 2 0.509391
ASTN2 astrotactin 2 0.509159
LPP LIM domain containing preferred translocation partner in lipoma 0.508699
LASP1 LIM and SH3 protein 1 0.508017
BCAP31 B-cell receptor-associated protein 31 0.507568
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.504316
TTC27 tetratricopeptide repeat domain 27 0.503483
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.501857
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 0.501857
CABS1 calcium-binding protein, spermatid-specific 1 0.501459
BMPER BMP binding endothelial regulator 0.501459
PALLD palladin, cytoskeletal associated protein 0.498388
COL4A2 collagen, type IV, alpha 2 0.497193
BICC1 BicC family RNA binding protein 1 0.496606
ANK2 ankyrin 2, neuronal 0.495641
CFAP43 cilia and flagella associated protein 43 0.494133
NSRP1 nuclear speckle splicing regulatory protein 1 0.493763
AMPH amphiphysin 0.493763
HLX H2.0-like homeobox 0.492848
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 0.492487
LIPC lipase, hepatic 0.492307
CARD6 caspase recruitment domain family, member 6 0.489171
GRAMD1B GRAM domain containing 1B 0.486693
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.485639
MAST2 microtubule associated serine/threonine kinase 2 0.483925
DDIAS DNA damage-induced apoptosis suppressor 0.46563
SLC44A4 solute carrier family 44, member 4 0.446509