hearing abnormality Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description An abnormality of the sensory perception of sound. (Human Phenotype Ontology, HP_0000364)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0000364
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Genes

150 genes associated with the hearing abnormality phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
DMD dystrophin 1.50337
MIR99AHG mir-99a-let-7c cluster host gene 1.49777
PTPRO protein tyrosine phosphatase, receptor type, O 1.33428
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 1.23766
WBSCR17 Williams-Beuren syndrome chromosome region 17 1.23436
HIP1 huntingtin interacting protein 1 1.23265
CDH12 cadherin 12, type 2 (N-cadherin 2) 1.16497
FAT3 FAT atypical cadherin 3 1.155
PRKCB protein kinase C, beta 1.13633
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 1.12528
ETV1 ets variant 1 1.11258
FAM155A family with sequence similarity 155, member A 1.10674
TRPC4 transient receptor potential cation channel, subfamily C, member 4 1.10312
DPYSL3 dihydropyrimidinase-like 3 0.576549
PKNOX2 PBX/knotted 1 homeobox 2 0.462011
PTPRD protein tyrosine phosphatase, receptor type, D 0.456703
IQGAP2 IQ motif containing GTPase activating protein 2 0.450694
PDE9A phosphodiesterase 9A 0.441715
DTD1 D-tyrosyl-tRNA deacylase 1 0.427168
CMIP c-Maf inducing protein 0.424814
PTPRK protein tyrosine phosphatase, receptor type, K 0.413807
EPAS1 endothelial PAS domain protein 1 0.412891
PRCP prolylcarboxypeptidase (angiotensinase C) 0.412842
YAP1 Yes-associated protein 1 0.412794
KLHL25 kelch-like family member 25 0.411171
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.409511
MMP8 matrix metallopeptidase 8 0.409511
MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 0.409292
SLCO6A1 solute carrier organic anion transporter family, member 6A1 0.408428
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.408335
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.407581
FMN1 formin 1 0.407498
PTPRG protein tyrosine phosphatase, receptor type, G 0.407351
RIMBP2 RIMS binding protein 2 0.40696
QRFPR pyroglutamylated RFamide peptide receptor 0.406809
COMMD10 COMM domain containing 10 0.406603
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.406403
DIAPH3 diaphanous-related formin 3 0.406388
LOC284379 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 pseudogene 0.406153
TACC2 transforming, acidic coiled-coil containing protein 2 0.406126
LUZP2 leucine zipper protein 2 0.405603
FGF14 fibroblast growth factor 14 0.405565
SALL3 spalt-like transcription factor 3 0.405178
KIAA0895 KIAA0895 0.405128
PCDH15 protocadherin-related 15 0.404608
ANGPT4 angiopoietin 4 0.404574
CLSTN2 calsyntenin 2 0.404379
ALPK2 alpha-kinase 2 0.403749
PIBF1 progesterone immunomodulatory binding factor 1 0.403403
KRT82 keratin 82, type II 0.402647
MFSD1 major facilitator superfamily domain containing 1 0.402417
UBE2Q2P1 ubiquitin-conjugating enzyme E2Q family member 2 pseudogene 1 0.402102
PARK2 parkin RBR E3 ubiquitin protein ligase 0.401823
LOC100129620 uncharacterized LOC100129620 0.401576
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 0.40156
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.401404
ROR1 receptor tyrosine kinase-like orphan receptor 1 0.400158
KIF26B kinesin family member 26B 0.396022
LRRN1 leucine rich repeat neuronal 1 0.395376
CSMD1 CUB and Sushi multiple domains 1 0.393942
MSRA methionine sulfoxide reductase A 0.393942
PLCE1 phospholipase C, epsilon 1 0.392924
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 0.390316
WDR33 WD repeat domain 33 0.390031
ZNF496 zinc finger protein 496 0.389969
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.389633
GPHN gephyrin 0.389308
LOC100287944 uncharacterized LOC100287944 0.388456
ZNF146 zinc finger protein 146 0.388111
FLJ45872 0.387686
PEX14 peroxisomal biogenesis factor 14 0.386765
TMEM135 transmembrane protein 135 0.385603
PTPRT protein tyrosine phosphatase, receptor type, T 0.385502
CD209 CD209 molecule 0.384222
EFNA5 ephrin-A5 0.382228
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.381783
LMO7 LIM domain 7 0.381547
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.381449
GPR155 G protein-coupled receptor 155 0.380587
FGD4 FYVE, RhoGEF and PH domain containing 4 0.380142
ASXL2 additional sex combs like transcriptional regulator 2 0.379509
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.378906
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 0.377334
FOXP1 forkhead box P1 0.377236
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.377069
LINC00486 long intergenic non-protein coding RNA 486 0.376608
C1ORF87 chromosome 1 open reading frame 87 0.376013
STIM2 stromal interaction molecule 2 0.375889
FRMD4A FERM domain containing 4A 0.375643
TP63 tumor protein p63 0.375403
LOC100507462 uncharacterized LOC100507462 0.375284
CREB5 cAMP responsive element binding protein 5 0.374047
REN renin 0.37373
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 0.372631
TENM1 teneurin transmembrane protein 1 0.371273
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.371018
KISS1 KiSS-1 metastasis-suppressor 0.371018
TMEM260 transmembrane protein 260 0.370523
TSPAN9 tetraspanin 9 0.370443
MYOM2 myomesin 2 0.370204
CHN2 chimerin 2 0.369969
AIRE autoimmune regulator 0.36951
COL23A1 collagen, type XXIII, alpha 1 0.369436
CADPS Ca++-dependent secretion activator 0.369214
LGMN legumain 0.368996
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.368026
PDZD8 PDZ domain containing 8 0.367377
STK3 serine/threonine kinase 3 0.367251
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.367189
TTLL11 tubulin tyrosine ligase-like family member 11 0.366942
PRMT3 protein arginine methyltransferase 3 0.36682
EGFEM1P EGF-like and EMI domain containing 1, pseudogene 0.3667
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.3667
TNIK TRAF2 and NCK interacting kinase 0.3667
TRIM23 tripartite motif containing 23 0.36664
NUB1 negative regulator of ubiquitin-like proteins 1 0.366521
TGFB2 transforming growth factor, beta 2 0.366521
T T, brachyury homolog (mouse) 0.366463
GTPBP8 GTP-binding protein 8 (putative) 0.366058
CHL1 cell adhesion molecule L1-like 0.366058
KCNK9 potassium channel, two pore domain subfamily K, member 9 0.365556
ACSS1 acyl-CoA synthetase short-chain family member 1 0.365447
KIN Kin17 DNA and RNA binding protein 0.364969
GRID2 glutamate receptor, ionotropic, delta 2 0.364711
ASTN2 astrotactin 2 0.36466
LPP LIM domain containing preferred translocation partner in lipoma 0.364559
LASP1 LIM and SH3 protein 1 0.364408
BCAP31 B-cell receptor-associated protein 31 0.364309
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.36355
TTC27 tetratricopeptide repeat domain 27 0.36335
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit 0.362959
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.362959
BMPER BMP binding endothelial regulator 0.362862
CABS1 calcium-binding protein, spermatid-specific 1 0.362862
PALLD palladin, cytoskeletal associated protein 0.362163
COL4A2 collagen, type IV, alpha 2 0.361893
BICC1 BicC family RNA binding protein 1 0.36176
ANK2 ankyrin 2, neuronal 0.361542
CFAP43 cilia and flagella associated protein 43 0.3612
AMPH amphiphysin 0.361115
NSRP1 nuclear speckle splicing regulatory protein 1 0.361115
HLX H2.0-like homeobox 0.360907
NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa 0.360825
LIPC lipase, hepatic 0.360784
CARD6 caspase recruitment domain family, member 6 0.360067
GRAMD1B GRAM domain containing 1B 0.359497
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.359276
MAST2 microtubule associated serine/threonine kinase 2 0.358916
DDIAS DNA damage-induced apoptosis suppressor 0.354865
SLC44A4 solute carrier family 44, member 4 0.350681