headache Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve. (Human Phenotype Ontology, HP_0002315)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0002315
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Genes

134 genes associated with the headache phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
HBB hemoglobin, beta 2.36493
OR51F1 olfactory receptor, family 51, subfamily F, member 1 (gene/pseudogene) 1.79316
OR51B5 olfactory receptor, family 51, subfamily B, member 5 1.6456
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 1.5462
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 1.41863
LRP1 low density lipoprotein receptor-related protein 1 1.28733
TRPM8 transient receptor potential cation channel, subfamily M, member 8 1.19958
CDH13 cadherin 13 1.08774
POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) 1.06211
ZNF804A zinc finger protein 804A 1.04365
PRDM16 PR domain containing 16 0.95402
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 0.899912
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.886251
OR51E2 olfactory receptor, family 51, subfamily E, member 2 0.881393
MAST2 microtubule associated serine/threonine kinase 2 0.850788
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 0.844241
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.844241
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.834343
PLXNA4 plexin A4 0.834343
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 0.817516
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.809986
PARK2 parkin RBR E3 ubiquitin protein ligase 0.809986
FAM53B family with sequence similarity 53, member B 0.7965
CIAPIN1 cytokine induced apoptosis inhibitor 1 0.747666
STON2 stonin 2 0.734535
MAML2 mastermind-like 2 (Drosophila) 0.734535
WWOX WW domain containing oxidoreductase 0.722116
MEIS1 Meis homeobox 1 0.703894
MTMR10 myotubularin related protein 10 0.703894
HNMT histamine N-methyltransferase 0.697013
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 0.687523
STAC SH3 and cysteine rich domain 0.681679
TSHZ2 teashirt zinc finger homeobox 2 0.681679
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.661809
PHACTR1 phosphatase and actin regulator 1 0.652197
OR13D1 olfactory receptor, family 13, subfamily D, member 1 0.639858
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.624663
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.622665
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.613082
LOC648987 uncharacterized LOC648987 0.609408
ZNF329 zinc finger protein 329 0.602436
RYR2 ryanodine receptor 2 (cardiac) 0.602436
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.597506
OPCML opioid binding protein/cell adhesion molecule-like 0.594349
LOC400927 TPTE and PTEN homologous inositol lipid phosphatase pseudogene 0.592807
LINC01587 long intergenic non-protein coding RNA 1587 0.591289
SUGCT succinyl-CoA:glutarate-CoA transferase 0.586853
DCLK1 doublecortin-like kinase 1 0.580678
ASTN2 astrotactin 2 0.572823
DEPTOR DEP domain containing MTOR-interacting protein 0.562717
MEF2D myocyte enhancer factor 2D 0.52897
FBN2 fibrillin 2 0.425116
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.422406
RABGAP1L RAB GTPase activating protein 1-like 0.411267
HPSE2 heparanase 2 (inactive) 0.410769
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 0.40911
MRVI1 murine retrovirus integration site 1 homolog 0.406676
SMYD3 SET and MYND domain containing 3 0.404074
KCNK5 potassium channel, two pore domain subfamily K, member 5 0.401236
ACTN4 actinin, alpha 4 0.399275
TGFB1 transforming growth factor, beta 1 0.397588
FOXP1 forkhead box P1 0.396438
KSR2 kinase suppressor of ras 2 0.394688
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.393429
ATF7 activating transcription factor 7 0.393046
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.392915
CTIF CBP80/20-dependent translation initiation factor 0.390074
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.386911
SORBS1 sorbin and SH3 domain containing 1 0.380484
HAUS1 HAUS augmin-like complex, subunit 1 0.356732
LEPROTL1 leptin receptor overlapping transcript-like 1 0.356732
PRKG1 protein kinase, cGMP-dependent, type I 0.35372
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.351596
MMP17 matrix metallopeptidase 17 (membrane-inserted) 0.349897
WAPAL wings apart-like homolog (Drosophila) 0.348436
MRPL37 mitochondrial ribosomal protein L37 0.346142
WASL Wiskott-Aldrich syndrome-like 0.34437
MARCH4 membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase 0.34437
VSTM4 V-set and transmembrane domain containing 4 0.34437
KIAA1456 KIAA1456 0.341581
ADAMTSL1 ADAMTS-like 1 0.338676
ARL15 ADP-ribosylation factor-like 15 0.338502
LIMCH1 LIM and calponin homology domains 1 0.338502
RSU1 Ras suppressor protein 1 0.338502
ZDHHC6 zinc finger, DHHC-type containing 6 0.338502
KANK1 KN motif and ankyrin repeat domains 1 0.33503
GFRA1 GDNF family receptor alpha 1 0.33503
NRP1 neuropilin 1 0.33503
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.332291
CDKN2B-AS1 CDKN2B antisense RNA 1 0.332291
CHRM2 cholinergic receptor, muscarinic 2 0.332291
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.332291
SNX24 sorting nexin 24 0.332291
INSIG2 insulin induced gene 2 0.331986
NSD1 nuclear receptor binding SET domain protein 1 0.330164
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 0.328434
SV2C synaptic vesicle glycoprotein 2C 0.328434
ADRA1B adrenoceptor alpha 1B 0.326976
PHF20 PHD finger protein 20 0.326976
IGLL1 immunoglobulin lambda-like polypeptide 1 0.325689
FRMD4A FERM domain containing 4A 0.325689
COX7B2 cytochrome c oxidase subunit VIIb2 0.325689
TBXAS1 thromboxane A synthase 1 (platelet) 0.325689
PTPRD protein tyrosine phosphatase, receptor type, D 0.325689
BPIFC BPI fold containing family C 0.325689
CASZ1 castor zinc finger 1 0.324368
STK10 serine/threonine kinase 10 0.324368
NBEA neurobeachin 0.324368
ZNF555 zinc finger protein 555 0.323693
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 0.323496
NF1 neurofibromin 1 0.321632
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 0.321066
ALK anaplastic lymphoma receptor tyrosine kinase 0.315683
FAM49B family with sequence similarity 49, member B 0.315463
MYLK4 myosin light chain kinase family, member 4 0.315408
ZNF311 zinc finger protein 311 0.314372
NXPH1 neurexophilin 1 0.313815
NAV2 neuron navigator 2 0.313755
COG3 component of oligomeric golgi complex 3 0.311437
GRM7 glutamate receptor, metabotropic 7 0.311437
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.310746
MYO3B myosin IIIB 0.309421
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.306028
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.302592
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.302176
CAMTA1 calmodulin binding transcription activator 1 0.30202
FAM155A family with sequence similarity 155, member A 0.301353
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.299879
STK39 serine threonine kinase 39 0.298039
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.297847
GOLM1 golgi membrane protein 1 0.295877
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 0.294858
IQGAP2 IQ motif containing GTPase activating protein 2 0.294661
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.272676