head and neck neoplasms Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651) (Experimental Factor Ontology, EFO_0004284)
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Genes

25 genes associated with the disease head and neck neoplasms in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APOE apolipoprotein E
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HELQ helicase, POLQ-like
MGMT O-6-methylguanine-DNA methyltransferase
MIR196A2 microRNA 196a-2
MSH2 mutS homolog 2
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit
TP53 tumor protein p53
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7
XPA xeroderma pigmentosum, complementation group A
XPC xeroderma pigmentosum, complementation group C
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3