glial cytoplasmic inclusion Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Non-membrane-bound cytoplasmic inclusions composed of 10-40 nm granule-coated fibrils. These inclusions have an abnormal accumulation of alpha-synuclein protein and are found in association with multiple system atrophy. (Gene Ontology, GO_0097409)
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Genes

82 proteins co-occuring with the glial cytoplasmic inclusion cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
FUS FUS RNA binding protein 1.31573
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.30497
TPPP tubulin polymerization promoting protein 1.30067
NIFK nucleolar protein interacting with the FHA domain of MKI67 1.15569
SNCAIP synuclein, alpha interacting protein 1.09798
TARDBP TAR DNA binding protein 1.07917
HBQ1 hemoglobin, theta 1 1.06903
OPTN optineurin 0.983419
MAPT microtubule-associated protein tau 0.980501
PACRG PARK2 co-regulated 0.961187
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 0.881477
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.86169
SPG11 spastic paraplegia 11 (autosomal recessive) 0.787817
THPO thrombopoietin 0.728389
CHMP2B charged multivesicular body protein 2B 0.728389
CRYAB crystallin, alpha B 0.72258
HDAC6 histone deacetylase 6 0.681155
GUCY2D guanylate cyclase 2D, membrane (retina-specific) 0.677238
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.666394
SNCB synuclein, beta 0.638005
LRRK2 leucine-rich repeat kinase 2 0.633305
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.623079
NDRG1 N-myc downstream regulated 1 0.612471
MAP1B microtubule-associated protein 1B 0.596435
FBXO7 F-box protein 7 0.583849
CEP57 centrosomal protein 57kDa 0.583431
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 0.5597
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.543176
RPL23 ribosomal protein L23 0.541117
MBP myelin basic protein 0.537827
RPS15A ribosomal protein S15a 0.533719
BPI bactericidal/permeability-increasing protein 0.531668
LXN latexin 0.512455
SQSTM1 sequestosome 1 0.500664
PGM2 phosphoglucomutase 2 0.496205
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.488115
UBQLN2 ubiquilin 2 0.487711
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 0.444482
ESD esterase D 0.443689
KLK6 kallikrein-related peptidase 6 0.420428
PHF20 PHD finger protein 20 0.41886
MMP10 matrix metallopeptidase 10 0.410259
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.395873
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 0.377354
GYPC glycophorin C (Gerbich blood group) 0.376586
GSK3B glycogen synthase kinase 3 beta 0.374283
MAP2 microtubule-associated protein 2 0.372366
NBR1 neighbor of BRCA1 gene 1 0.367771
SNCG synuclein, gamma (breast cancer-specific protein 1) 0.351382
CDK5 cyclin-dependent kinase 5 0.344556
INA internexin neuronal intermediate filament protein, alpha 0.330966
GADD45B growth arrest and DNA-damage-inducible, beta 0.326453
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.31596
GCDH glutaryl-CoA dehydrogenase 0.314465
SP1 Sp1 transcription factor 0.301425
GRM7 glutamate receptor, metabotropic 7 0.298455
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 0.289938
TCN2 transcobalamin II 0.279245
RUNX3 runt-related transcription factor 3 0.278141
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.257652
MDK midkine (neurite growth-promoting factor 2) 0.248216
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 0.245685
GLO1 glyoxalase I 0.243519
PGM1 phosphoglucomutase 1 0.238837
SUMF2 sulfatase modifying factor 2 0.238478
NPTN neuroplastin 0.23776
CP ceruloplasmin (ferroxidase) 0.232744
NUP62 nucleoporin 62kDa 0.232744
HBA1 hemoglobin, alpha 1 0.204718
TLR8 toll-like receptor 8 0.204378
HBA2 hemoglobin, alpha 2 0.199993
ERVW-1 endogenous retrovirus group W, member 1 0.191777
TBX1 T-box 1 0.189222
HMGB2 high mobility group box 2 0.180634
TLR1 toll-like receptor 1 0.178299
GUCY2C guanylate cyclase 2C 0.172468
NPR1 natriuretic peptide receptor 1 0.167125
GC group-specific component (vitamin D binding protein) 0.167125
LDHB lactate dehydrogenase B 0.160658
ATXN3 ataxin 3 0.159856
TLR5 toll-like receptor 5 0.157943
DCTN1 dynactin 1 0.157943