glaucoma Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)|Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor. (Experimental Factor Ontology, EFO_0000516)
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Genes

160 genes co-occuring with the biological term glaucoma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACE angiotensin I converting enzyme
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
AFAP1 actin filament associated protein 1
ANGPTL7 angiopoietin-like 7
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
ASB10 ankyrin repeat and SOCS box containing 10
ATOH7 atonal homolog 7 (Drosophila)
BAK1 BCL2-antagonist/killer 1
BCL2L1 BCL2-like 1
BEST1 bestrophin 1
BMP4 bone morphogenetic protein 4
CA12 carbonic anhydrase XII
CALCRL calcitonin receptor-like
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAT catalase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2B-AS1 CDKN2B antisense RNA 1
CNTNAP4 contactin associated protein-like 4
COCH cochlin
COL11A1 collagen, type XI, alpha 1
COL5A1 collagen, type V, alpha 1
COL8A1 collagen, type VIII, alpha 1
COL8A2 collagen, type VIII, alpha 2
CPNE1 copine I
CSTA cystatin A (stefin A)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEFB4A defensin, beta 4A
EDN1 endothelin 1
EDNRA endothelin receptor type A
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
ELN elastin
ELOVL5 ELOVL fatty acid elongase 5
EPO erythropoietin
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FBN1 fibrillin 1
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FOXC1 forkhead box C1
FST follistatin
GJA1 gap junction protein, alpha 1, 43kDa
GLC1C glaucoma 1, open angle, C
GLC1H glaucoma 1, open angle, H (adult-onset)
GLC1L glaucoma 1, open angle, L (adult-onset)
GLC3C glaucoma 3, primary congenital, C
GMDS GDP-mannose 4,6-dehydratase
GREM1 gremlin 1, DAN family BMP antagonist
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAMP hepcidin antimicrobial peptide
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
LDLR low density lipoprotein receptor
LMX1B LIM homeobox transcription factor 1, beta
LOXL1 lysyl oxidase-like 1
LTBP2 latent transforming growth factor beta binding protein 2
MFRP membrane frizzled-related protein
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUTYH mutY homolog
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCK2 NCK adaptor protein 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NPPA natriuretic peptide A
NPR1 natriuretic peptide receptor 1
NRG2 neuregulin 2
NTF4 neurotrophin 4
NTM neurotrimin
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OCLM oculomedin
OGG1 8-oxoguanine DNA glycosylase
OPA1 optic atrophy 1 (autosomal dominant)
OPTC opticin
OPTN optineurin
PADI2 peptidyl arginine deiminase, type II
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
PEX5 peroxisomal biogenesis factor 5
PITX2 paired-like homeodomain 2
PLEKHA7 pleckstrin homology domain containing, family A member 7
PON1 paraoxonase 1
PRSS56 protease, serine, 56
PTGFR prostaglandin F receptor (FP)
PXDN peroxidasin
RFTN1 raftlin, lipid raft linker 1
RHOA ras homolog family member A
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1
SBF2 SET binding factor 2
SEC14L2 SEC14-like 2 (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SIX1 SIX homeobox 1
SIX6 SIX homeobox 6
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10
SOD1 superoxide dismutase 1, soluble
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SRBD1 S1 RNA binding domain 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBK1 TANK-binding kinase 1
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMCO1 transmembrane and coiled-coil domains 1
TNF tumor necrosis factor
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TP53 tumor protein p53
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPM5 transient receptor potential cation channel, subfamily M, member 5
TTR transthyretin
TYR tyrosinase
TYRP1 tyrosinase-related protein 1
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VCP valosin containing protein
VEGFA vascular endothelial growth factor A
VSX2 visual system homeobox 2
VWF von Willebrand factor
WDR36 WD repeat domain 36
WWTR1 WW domain containing transcription regulator 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
YAP1 Yes-associated protein 1
ZEB1 zinc finger E-box binding homeobox 1
ZNF469 zinc finger protein 469