geldanamycin-2688 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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200 genes differentially expressed following the geldanamycin-2688 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
AASS aminoadipate-semialdehyde synthase
ABHD3 abhydrolase domain containing 3
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
ANXA2P3 annexin A2 pseudogene 3
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BTNL8 butyrophilin-like 8
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD68 CD68 molecule
CD84 CD84 molecule
CD8B CD8b molecule
CDH10 cadherin 10, type 2 (T2-cadherin)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLCA2 chloride channel accessory 2
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CNPY4 canopy FGF signaling regulator 4
COL14A1 collagen, type XIV, alpha 1
COL1A2 collagen, type I, alpha 2
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CRELD2 cysteine-rich with EGF-like domains 2
CRYZ crystallin, zeta (quinone reductase)
DCAF17 DDB1 and CUL4 associated factor 17
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EHD2 EH-domain containing 2
EPB42 erythrocyte membrane protein band 4.2
EVI5 ecotropic viral integration site 5
F2RL1 coagulation factor II (thrombin) receptor-like 1
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FKBP4 FK506 binding protein 4, 59kDa
FLOT1 flotillin 1
FRMD4B FERM domain containing 4B
GJB3 gap junction protein, beta 3, 31kDa
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPC3 glypican 3
GPR137 G protein-coupled receptor 137
GULP1 GULP, engulfment adaptor PTB domain containing 1
HOXA4 homeobox A4
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA2 heat shock 70kDa protein 2
HSPA4L heat shock 70kDa protein 4-like
HSPB1 heat shock 27kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IDS iduronate 2-sulfatase
IL17RC interleukin 17 receptor C
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KIAA0226L KIAA0226-like
KRT17 keratin 17, type I
MBNL2 muscleblind-like splicing regulator 2
MCTP2 multiple C2 domains, transmembrane 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSRB2 methionine sulfoxide reductase B2
MUC6 mucin 6, oligomeric mucus/gel-forming
NF1 neurofibromin 1
NMU neuromedin U
NR4A2 nuclear receptor subfamily 4, group A, member 2
OTOF otoferlin
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PCDHGA10 protocadherin gamma subfamily A, 10
PCDHGA8 protocadherin gamma subfamily A, 8
PDE4B phosphodiesterase 4B, cAMP-specific
PDE4DIP phosphodiesterase 4D interacting protein
PEG10 paternally expressed 10
PP14571 uncharacterized LOC100130449
PPID peptidylprolyl isomerase D
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RB1 retinoblastoma 1
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SEZ6L seizure related 6 homolog (mouse)-like
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC35F5 solute carrier family 35, member F5
SPATS2L spermatogenesis associated, serine-rich 2-like
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRSF5 serine/arginine-rich splicing factor 5
STARD13 StAR-related lipid transfer (START) domain containing 13
STIP1 stress-induced phosphoprotein 1
TAAR3 trace amine associated receptor 3 (gene/pseudogene)
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TAPT1 transmembrane anterior posterior transformation 1
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TESK1 testis-specific kinase 1
THBS1 thrombospondin 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNP2 transition protein 2 (during histone to protamine replacement)
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
ZNF224 zinc finger protein 224
ZNF415 zinc finger protein 415

decreased expression

Symbol Name
ABHD11 abhydrolase domain containing 11
AEN apoptosis enhancing nuclease
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
ARPC5L actin related protein 2/3 complex, subunit 5-like
BAHCC1 BAH domain and coiled-coil containing 1
BATF3 basic leucine zipper transcription factor, ATF-like 3
BBC3 BCL2 binding component 3
BHLHE41 basic helix-loop-helix family, member e41
BOLA1 bolA family member 1
BYSL bystin-like
C10ORF2 chromosome 10 open reading frame 2
C5AR1 complement component 5a receptor 1
C8A complement component 8, alpha polypeptide
C9ORF91 chromosome 9 open reading frame 91
CBX7 chromobox homolog 7
CD3EAP CD3e molecule, epsilon associated protein
CD69 CD69 molecule
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHML choroideremia-like (Rab escort protein 2)
CHST10 carbohydrate sulfotransferase 10
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CLEC2D C-type lectin domain family 2, member D
CNN1 calponin 1, basic, smooth muscle
COL15A1 collagen, type XV, alpha 1
CPNE7 copine VII
CUL9 cullin 9
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DHDDS dehydrodolichyl diphosphate synthase
DHRS11 dehydrogenase/reductase (SDR family) member 11
DPH2 DPH2 homolog (S. cerevisiae)
DUSP14 dual specificity phosphatase 14
DUSP2 dual specificity phosphatase 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ENDOG endonuclease G
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EYA3 EYA transcriptional coactivator and phosphatase 3
FAM86B1 family with sequence similarity 86, member B1
FHOD1 formin homology 2 domain containing 1
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
GFOD1 glucose-fructose oxidoreductase domain containing 1
GID4 GID complex subunit 4
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPR22 G protein-coupled receptor 22
GPR68 G protein-coupled receptor 68
HYAL2 hyaluronoglucosaminidase 2
IER2 immediate early response 2
INHBE inhibin, beta E
IRF7 interferon regulatory factor 7
JAG2 jagged 2
MAPKBP1 mitogen-activated protein kinase binding protein 1
METTL1 methyltransferase like 1
MOCS3 molybdenum cofactor synthesis 3
MPI mannose phosphate isomerase
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTHFSD methenyltetrahydrofolate synthetase domain containing
MXD3 MAX dimerization protein 3
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NPFFR1 neuropeptide FF receptor 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLA2G12A phospholipase A2, group XIIA
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PRDM13 PR domain containing 13
PRKCZ protein kinase C, zeta
PRR7 proline rich 7 (synaptic)
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PUS1 pseudouridylate synthase 1
PYCRL pyrroline-5-carboxylate reductase-like
RGS16 regulator of G-protein signaling 16
RNF122 ring finger protein 122
RPP25 ribonuclease P/MRP 25kDa subunit
RPUSD2 RNA pseudouridylate synthase domain containing 2
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SETD6 SET domain containing 6
SGMS1 sphingomyelin synthase 1
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC10A3 solute carrier family 10, member 3
SLC12A8 solute carrier family 12, member 8
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SPATA2L spermatogenesis associated 2-like
SRD5A3 steroid 5 alpha-reductase 3
STC2 stanniocalcin 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TCTA T-cell leukemia translocation altered
TEC tec protein tyrosine kinase
TERT telomerase reverse transcriptase
THBS3 thrombospondin 3
TIMP2 TIMP metallopeptidase inhibitor 2
TNF tumor necrosis factor
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB3 tribbles pseudokinase 3
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF215 zinc finger protein 215