fulvestrant-7490 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the fulvestrant-7490 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNT aryl hydrocarbon receptor nuclear translocator
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BCL2L1 BCL2-like 1
BLNK B-cell linker
BTBD7 BTB (POZ) domain containing 7
BTG2 BTG family, member 2
CA5BP1 carbonic anhydrase VB pseudogene 1
CCNG2 cyclin G2
CD3D CD3d molecule, delta (CD3-TCR complex)
CFLAR CASP8 and FADD-like apoptosis regulator
COL1A1 collagen, type I, alpha 1
CSNK1G1 casein kinase 1, gamma 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DGCR2 DiGeorge syndrome critical region gene 2
DXO decapping exoribonuclease
EPHA3 EPH receptor A3
ESR1 estrogen receptor 1
FEM1B fem-1 homolog b (C. elegans)
FGFR2 fibroblast growth factor receptor 2
FKBP10 FK506 binding protein 10, 65 kDa
FLOT1 flotillin 1
FLOT2 flotillin 2
FNDC3A fibronectin type III domain containing 3A
FNTB farnesyltransferase, CAAX box, beta
GAMT guanidinoacetate N-methyltransferase
GK glycerol kinase
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GM2A GM2 ganglioside activator
GPER1 G protein-coupled estrogen receptor 1
GRM4 glutamate receptor, metabotropic 4
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HIPK3 homeodomain interacting protein kinase 3
HP1BP3 heterochromatin protein 1, binding protein 3
IGHM immunoglobulin heavy constant mu
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1A interleukin 1, alpha
ING4 inhibitor of growth family, member 4
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
ITFG2 integrin alpha FG-GAP repeat containing 2
KAZALD1 Kazal-type serine peptidase inhibitor domain 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA1109 KIAA1109
KIF22 kinesin family member 22
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
LIMCH1 LIM and calponin homology domains 1
LOC257152 uncharacterized LOC257152
LRRC14 leucine rich repeat containing 14
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTBP4 latent transforming growth factor beta binding protein 4
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MCL1 myeloid cell leukemia 1
MDFI MyoD family inhibitor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED20 mediator complex subunit 20
NCOA2 nuclear receptor coactivator 2
NF1 neurofibromin 1
NPIPB3 nuclear pore complex interacting protein family, member B3
OGFR opioid growth factor receptor
OSBPL7 oxysterol binding protein-like 7
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCLO piccolo presynaptic cytomatrix protein
PDCD6 programmed cell death 6
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PML promyelocytic leukemia
PRLR prolactin receptor
PSD4 pleckstrin and Sec7 domain containing 4
PTK7 protein tyrosine kinase 7 (inactive)
RARG retinoic acid receptor, gamma
RNF6 ring finger protein (C3H2C3 type) 6
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SAT1 spermidine/spermine N1-acetyltransferase 1
SENP7 SUMO1/sentrin specific peptidase 7
SETD8 SET domain containing (lysine methyltransferase) 8
SLC48A1 solute carrier family 48 (heme transporter), member 1
SNAP23 synaptosomal-associated protein, 23kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPAG8 sperm associated antigen 8
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
STAT2 signal transducer and activator of transcription 2, 113kDa
STIP1 stress-induced phosphoprotein 1
STMN1 stathmin 1
STON1 stonin 1
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TBC1D5 TBC1 domain family, member 5
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM259 transmembrane protein 259
TOX4 TOX high mobility group box family member 4
TPP1 tripeptidyl peptidase I
TRIM23 tripartite motif containing 23
TSC22D3 TSC22 domain family, member 3
WDR1 WD repeat domain 1
ZDHHC17 zinc finger, DHHC-type containing 17
ZNF350 zinc finger protein 350
ZNF532 zinc finger protein 532
ZNF639 zinc finger protein 639
ZSCAN31 zinc finger and SCAN domain containing 31

decreased expression

Symbol Name
APOC4 apolipoprotein C-IV
ARC activity-regulated cytoskeleton-associated protein
ARTN artemin
BARX2 BARX homeobox 2
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BFSP1 beaded filament structural protein 1, filensin
C17ORF53 chromosome 17 open reading frame 53
CCDC88C coiled-coil domain containing 88C
CCND1 cyclin D1
CD48 CD48 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CHSY1 chondroitin sulfate synthase 1
CIDEC cell death-inducing DFFA-like effector c
CST6 cystatin E/M
CXCL12 chemokine (C-X-C motif) ligand 12
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DEFA4 defensin, alpha 4, corticostatin
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DPF1 D4, zinc and double PHD fingers family 1
EGR3 early growth response 3
FAM110B family with sequence similarity 110, member B
FER fer (fps/fes related) tyrosine kinase
FHL2 four and a half LIM domains 2
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
GATA4 GATA binding protein 4
GJA1 gap junction protein, alpha 1, 43kDa
GPR157 G protein-coupled receptor 157
GPR21 G protein-coupled receptor 21
GREB1 growth regulation by estrogen in breast cancer 1
GRPR gastrin-releasing peptide receptor
GSTCD glutathione S-transferase, C-terminal domain containing
HHAT hedgehog acyltransferase
HIST1H1D histone cluster 1, H1d
HIST1H4C histone cluster 1, H4c
HOXA3 homeobox A3
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
IL17RB interleukin 17 receptor B
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JAK2 Janus kinase 2
KDM8 lysine (K)-specific demethylase 8
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF10 Kruppel-like factor 10
LINC00341 long intergenic non-protein coding RNA 341
MAK male germ cell-associated kinase
MAP6D1 MAP6 domain containing 1
MFSD6 major facilitator superfamily domain containing 6
MICB MHC class I polypeptide-related sequence B
MPPED2 metallophosphoesterase domain containing 2
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NFE2L3 nuclear factor, erythroid 2-like 3
NKAIN1 Na+/K+ transporting ATPase interacting 1
NOL10 nucleolar protein 10
NPY1R neuropeptide Y receptor Y1
NRDE2 NRDE-2, necessary for RNA interference, domain containing
ONECUT2 one cut homeobox 2
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAIP2B poly(A) binding protein interacting protein 2B
PDE8B phosphodiesterase 8B
PIPOX pipecolic acid oxidase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PQLC2 PQ loop repeat containing 2
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGES prostaglandin E synthase
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASIP1 Ras interacting protein 1
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RBL1 retinoblastoma-like 1
RHBDD3 rhomboid domain containing 3
RLN1 relaxin 1
SAYSD1 SAYSVFN motif domain containing 1
SDCCAG3 serologically defined colon cancer antigen 3
SGK1 serum/glucocorticoid regulated kinase 1
SH3D21 SH3 domain containing 21
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
SLC44A1 solute carrier family 44 (choline transporter), member 1
SMAD7 SMAD family member 7
STC2 stanniocalcin 2
STXBP5L syntaxin binding protein 5-like
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SYBU syntabulin (syntaxin-interacting)
SYNPO synaptopodin
TCP11 t-complex 11, testis-specific
TCTN2 tectonic family member 2
TMCC2 transmembrane and coiled-coil domain family 2
TMEM183A transmembrane protein 183A
TMEM62 transmembrane protein 62
TMPRSS3 transmembrane protease, serine 3
TMPRSS4 transmembrane protease, serine 4
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP36 ubiquitin specific peptidase 36
ZNF205 zinc finger protein 205