frontotemporal dementia Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A basal ganglia disease characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language. (Human Disease Ontology, DOID_9255)
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Genes

239 genes co-occuring with the disease frontotemporal dementia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
GRN granulin 3.17561
TARDBP TAR DNA binding protein 3.14146
MAPT microtubule-associated protein tau 3.10091
C9ORF72 chromosome 9 open reading frame 72 3.04211
VCP valosin containing protein 2.54074
FUS FUS RNA binding protein 2.47579
CHMP2B charged multivesicular body protein 2B 2.42634
TMEM106B transmembrane protein 106B 2.08915
UBQLN2 ubiquilin 2 1.86232
CBS cystathionine-beta-synthase 1.54893
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 1.54098
PSEN1 presenilin 1 1.48779
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 1.47506
SQSTM1 sequestosome 1 1.42762
SORT1 sortilin 1 1.3542
APOE apolipoprotein E 1.34461
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 1.32236
PSEN2 presenilin 2 1.32236
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 1.3027
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 1.2861
IFT74 intraflagellar transport 74 1.25645
TREM2 triggering receptor expressed on myeloid cells 2 1.23299
ATXN2 ataxin 2 1.22952
RUNDC3A RUN domain containing 3A 1.19316
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 1.12741
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 1.09881
DCTN1 dynactin 1 1.04588
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 1.04125
TNPO1 transportin 1 1.02861
UNC13A unc-13 homolog A (C. elegans) 0.977165
TRA2B transformer 2 beta homolog (Drosophila) 0.975482
INA internexin neuronal intermediate filament protein, alpha 0.951187
LY6G6F lymphocyte antigen 6 complex, locus G6F 0.950769
LY6G6D lymphocyte antigen 6 complex, locus G6D 0.950769
SIGMAR1 sigma non-opioid intracellular receptor 1 0.938289
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.934141
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 0.897461
NEFH neurofilament, heavy polypeptide 0.885569
MOB3B MOB kinase activator 3B 0.877786
RRM2 ribonucleotide reductase M2 0.871643
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 0.869596
TMEM106A transmembrane protein 106A 0.865093
KANSL1 KAT8 regulatory NSL complex subunit 1 0.849945
APP amyloid beta (A4) precursor protein 0.838885
BCHE butyrylcholinesterase 0.838476
CDK5 cyclin-dependent kinase 5 0.832738
SLC25A39 solute carrier family 25, member 39 0.828229
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.824128
CSTB cystatin B (stefin B) 0.816745
ACHE acetylcholinesterase (Yt blood group) 0.801974
RBM45 RNA binding motif protein 45 0.799513
WNT2 wingless-type MMTV integration site family member 2 0.799513
TMEM40 transmembrane protein 40 0.793361
OPTN optineurin 0.784345
DCP1B decapping mRNA 1B 0.777795
TPRKB TP53RK binding protein 0.777795
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.763086
VGF VGF nerve growth factor inducible 0.755749
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 0.752898
KIF24 kinesin family member 24 0.750864
AGRN agrin 0.748017
MAP4 microtubule-associated protein 4 0.741923
PRNP prion protein 0.729762
IFNK interferon, kappa 0.706351
RBM43 RNA binding motif protein 43 0.695504
PCBP3 poly(rC) binding protein 3 0.672722
HDAC6 histone deacetylase 6 0.672324
UBXN6 UBX domain protein 6 0.670333
UBAP2 ubiquitin associated protein 2 0.66914
MAP2 microtubule-associated protein 2 0.666755
LRRK2 leucine-rich repeat kinase 2 0.658818
SRSF9 serine/arginine-rich splicing factor 9 0.656441
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.65565
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.64577
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.641039
EWSR1 EWS RNA-binding protein 1 0.638282
ATXN3 ataxin 3 0.631598
SRSF11 serine/arginine-rich splicing factor 11 0.631598
DNAH8 dynein, axonemal, heavy chain 8 0.631205
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 0.6214
SPAG8 sperm associated antigen 8 0.619051
TAGLN3 transgelin 3 0.612401
ADNP activity-dependent neuroprotector homeobox 0.610057
STX12 syntaxin 12 0.60108
KIAA0196 KIAA0196 0.594064
ERMP1 endoplasmic reticulum metallopeptidase 1 0.590948
PHF1 PHD finger protein 1 0.589779
UBQLN1 ubiquilin 1 0.588222
WDFY1 WD repeat and FYVE domain containing 1 0.584719
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.583941
CCDC62 coiled-coil domain containing 62 0.579272
MOBP myelin-associated oligodendrocyte basic protein 0.571884
NEFM neurofilament, medium polypeptide 0.562946
EFHD2 EF-hand domain family, member D2 0.558674
NOTUM notum pectinacetylesterase homolog (Drosophila) 0.556732
PCBP2 poly(rC) binding protein 2 0.554791
SRP54 signal recognition particle 54kDa 0.551298
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 0.534635
PFN1 profilin 1 0.529994
SPPL2C signal peptide peptidase like 2C 0.527676
DNALI1 dynein, axonemal, light intermediate chain 1 0.524588
SRSF1 serine/arginine-rich splicing factor 1 0.519961
ABLIM1 actin binding LIM protein 1 0.51534
RMDN3 regulator of microtubule dynamics 3 0.510728
PRMT8 protein arginine methyltransferase 8 0.507657
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.50689
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 0.502292
MAP6 microtubule-associated protein 6 0.501909
FAF2 Fas associated factor family member 2 0.501527
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.494266
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.486266
SPPL2A signal peptide peptidase like 2A 0.485505
CRYAB crystallin, alpha B 0.483604
UBB ubiquitin B 0.469576
HTT huntingtin 0.463149
HIST1H1E histone cluster 1, H1e 0.462772
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.460506
SORCS3 sortilin-related VPS10 domain containing receptor 3 0.459373
SOD2 superoxide dismutase 2, mitochondrial 0.456355
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 0.446182
VGLL3 vestigial-like family member 3 0.445805
ADGRB3 adhesion G protein-coupled receptor B3 0.439034
SPPL2B signal peptide peptidase like 2B 0.438282
FZD2 frizzled class receptor 2 0.436778
FNIP2 folliculin interacting protein 2 0.430017
UBAP1 ubiquitin associated protein 1 0.42739
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 0.42739
CHMP5 charged multivesicular body protein 5 0.425139
LAMP1 lysosomal-associated membrane protein 1 0.42289
SP4 Sp4 transcription factor 0.416896
FNIP1 folliculin interacting protein 1 0.416521
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.409414
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 0.409414
FNDC3A fibronectin type III domain containing 3A 0.404184
CST3 cystatin C 0.390025
MAP1B microtubule-associated protein 1B 0.388166
TTBK1 tau tubulin kinase 1 0.383708
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 0.383337
PLIN4 perilipin 4 0.381852
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.379256
UBN1 ubinuclein 1 0.377402
ZNF699 zinc finger protein 699 0.375179
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta 0.369628
CSNK1D casein kinase 1, delta 0.368888
NMB neuromedin B 0.368518
PABPC1 poly(A) binding protein, cytoplasmic 1 0.368518
GSK3B glycogen synthase kinase 3 beta 0.362239
MPEG1 macrophage expressed 1 0.359657
ETF1 eukaryotic translation termination factor 1 0.35082
RRM1 ribonucleotide reductase M1 0.35082
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.344574
RD3 retinal degeneration 3 0.340173
TYROBP TYRO protein tyrosine kinase binding protein 0.339806
KPNB1 karyopherin (importin) beta 1 0.338707
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.333218
SYP synaptophysin 0.32373
EPHA6 EPH receptor A6 0.321181
NTNG1 netrin G1 0.32009
DUSP12 dual specificity phosphatase 12 0.317909
DUSP8 dual specificity phosphatase 8 0.317909
TBC1D24 TBC1 domain family, member 24 0.315003
GRID2 glutamate receptor, ionotropic, delta 2 0.312464
ATG7 autophagy related 7 0.311377
RSPO2 R-spondin 2 0.31029
SGSH N-sulfoglucosamine sulfohydrolase 0.30848
ATP13A2 ATPase type 13A2 0.307033
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 0.301615
ALG10 ALG10, alpha-1,2-glucosyltransferase 0.300533
SMN2 survival of motor neuron 2, centromeric 0.296931
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 0.296571
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.295851
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 0.295132
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.293694
NTNG2 netrin G2 0.291539
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.289744
NUB1 negative regulator of ubiquitin-like proteins 1 0.287952
SEPT11 septin 11 0.28616
ELP3 elongator acetyltransferase complex subunit 3 0.285802
STAU1 staufen double-stranded RNA binding protein 1 0.276514
SLC30A3 solute carrier family 30 (zinc transporter), member 3 0.275445
SCG5 secretogranin V 0.274376
BDNF brain-derived neurotrophic factor 0.269398
PRMT3 protein arginine methyltransferase 3 0.260891
MATR3 matrin 3 0.260184
CRABP2 cellular retinoic acid binding protein 2 0.260184
CCNF cyclin F 0.255594
TFEB transcription factor EB 0.255594
GIGYF2 GRB10 interacting GYF protein 2 0.246799
SNX9 sorting nexin 9 0.246098
C10ORF2 chromosome 10 open reading frame 2 0.243295
KIN Kin17 DNA and RNA binding protein 0.242945
PARK2 parkin RBR E3 ubiquitin protein ligase 0.237357
MADD MAP-kinase activating death domain 0.236312
GZMM granzyme M (lymphocyte met-ase 1) 0.23492
SCG3 secretogranin III 0.230063
LGALS4 lectin, galactoside-binding, soluble, 4 0.224196
ATG5 autophagy related 5 0.224196
MAPK13 mitogen-activated protein kinase 13 0.219057
UNC119 unc-119 homolog (C. elegans) 0.219057
MAP1A microtubule-associated protein 1A 0.214297
TTBK2 tau tubulin kinase 2 0.212271
DROSHA drosha, ribonuclease type III 0.209918
CRHR1 corticotropin releasing hormone receptor 1 0.208914
SRSF2 serine/arginine-rich splicing factor 2 0.201308
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.200006
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 0.196779
HCRT hypocretin (orexin) neuropeptide precursor 0.194548
DPYSL3 dihydropyrimidinase-like 3 0.190786
HIST1H1C histone cluster 1, H1c 0.189244
RXRG retinoid X receptor, gamma 0.185612
NOTCH3 notch 3 0.183248
SIM1 single-minded family bHLH transcription factor 1 0.182957
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 0.182957
UBC ubiquitin C 0.179802
ANG angiogenin, ribonuclease, RNase A family, 5 0.179802
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.178126
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.177301
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.177301
CSN1S1 casein alpha s1 0.176215
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.175947
RPS27A ribosomal protein S27a 0.173314
CSF1R colony stimulating factor 1 receptor 0.172799
RAB38 RAB38, member RAS oncogene family 0.172291
C1ORF174 chromosome 1 open reading frame 174 0.170789
ANXA2 annexin A2 0.169571
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.168381
MSI1 musashi RNA-binding protein 1 0.166095
CA4 carbonic anhydrase IV 0.166095
YBX2 Y box binding protein 2 0.165435
ACE angiotensin I converting enzyme 0.165217
KLK6 kallikrein-related peptidase 6 0.165001
PHF6 PHD finger protein 6 0.164786
NOTCH4 notch 4 0.163729
A2M alpha-2-macroglobulin 0.162505
FOXO3 forkhead box O3 0.162306
NCL nucleolin 0.160203
RELN reelin 0.159838
CRMP1 collapsin response mediator protein 1 0.159124
HTRA2 HtrA serine peptidase 2 0.158434