foreign-body giant cell Gene Set

Dataset TISSUES Text-mining Tissue Protein Expression Evidence Scores
Category structural or functional annotations
Type tissue
Description Syncytium formed by the fusion of macrophages in response to an indigestible particle too large to be phagocytosed for example talc, silica or asbestos fibres. Multinucleated cells (fused macrophages), characteristic of granulomatous inflammation, which form around exogenous material in the skin. They are similar in appearance to Langhans giant cells, but foreign-body giant cells have more abundant chromatin and their nuclei are scattered in an irregular pattern in the cytoplasm. (BRENDA Tissue and Enzyme Source Ontology, BTO_0003107)
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Genes

81 proteins co-occuring with the tissue foreign-body giant cell in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.

Symbol Name Standardized Value
DCSTAMP dendrocyte expressed seven transmembrane protein 2.03535
OCSTAMP osteoclast stimulatory transmembrane protein 1.9159
IL4 interleukin 4 1.23272
CD68 CD68 molecule 1.17447
SEBOX SEBOX homeobox 1.10668
CTSK cathepsin K 1.10225
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.976315
IL13 interleukin 13 0.944366
MRC1 mannose receptor, C type 1 0.939636
FN1 fibronectin 1 0.931051
DGKQ diacylglycerol kinase, theta 110kDa 0.925479
ACPP acid phosphatase, prostate 0.919061
C3 complement component 3 0.864312
DGKD diacylglycerol kinase, delta 130kDa 0.85547
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.822339
ADAM12 ADAM metallopeptidase domain 12 0.767368
MNDA myeloid cell nuclear differentiation antigen 0.744214
MARCO macrophage receptor with collagenous structure 0.72322
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.682287
SLC7A4 solute carrier family 7, member 4 0.678617
DGKA diacylglycerol kinase, alpha 80kDa 0.63719
GCAT glycine C-acetyltransferase 0.633549
ACP5 acid phosphatase 5, tartrate resistant 0.606514
IL1B interleukin 1, beta 0.600077
NIPBL Nipped-B homolog (Drosophila) 0.597263
SIRPA signal-regulatory protein alpha 0.574816
ALB albumin 0.559254
ADAM8 ADAM metallopeptidase domain 8 0.557263
CALCR calcitonin receptor 0.537416
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.527534
PRPF4B pre-mRNA processing factor 4B 0.507064
TSPO translocator protein (18kDa) 0.501182
TLK1 tousled-like kinase 1 0.50079
CCL2 chemokine (C-C motif) ligand 2 0.499223
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 0.492963
STK4 serine/threonine kinase 4 0.477367
CA10 carbonic anhydrase X 0.476201
ADAM9 ADAM metallopeptidase domain 9 0.468048
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.462626
SPP1 secreted phosphoprotein 1 0.461852
PRKD3 protein kinase D3 0.459145
PLK4 polo-like kinase 4 0.45567
TNF tumor necrosis factor 0.449501
BMP2 bone morphogenetic protein 2 0.444115
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.443731
EDA ectodysplasin A 0.437589
MMP9 matrix metallopeptidase 9 0.435289
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 0.434523
KRT7 keratin 7, type II 0.420385
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.394953
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.389666
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 0.371245
CD9 CD9 molecule 0.371245
MARK2 MAP/microtubule affinity-regulating kinase 2 0.351485
ITGB8 integrin, beta 8 0.340757
ITGB6 integrin, beta 6 0.336704
KLK15 kallikrein-related peptidase 15 0.336704
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.32205
A1BG alpha-1-B glycoprotein 0.318042
GPR162 G protein-coupled receptor 162 0.317315
VWF von Willebrand factor 0.316951
ITGB7 integrin, beta 7 0.315135
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 0.312957
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.304279
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 0.293151
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.292436
BMP7 bone morphogenetic protein 7 0.287803
VCL vinculin 0.25457
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.250627
TCHH trichohyalin 0.250301
CEL carboxyl ester lipase 0.24804
ITGB4 integrin, beta 4 0.23781
CCR2 chemokine (C-C motif) receptor 2 0.232599
FHIT fragile histidine triad 0.23176
BAG1 BCL2-associated athanogene 0.228764
F8 coagulation factor VIII, procoagulant component 0.22415
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.223177
TNC tenascin C 0.215147
TIMP2 TIMP metallopeptidase inhibitor 2 0.214576
BGLAP bone gamma-carboxyglutamate (gla) protein 0.213291
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.212761