forebrain hypoplasia Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description underdevelopment or reduced size, usually due to a reduced number of cells, in the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions) (Mammalian Phenotype Ontology, MP_0000784)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0000784
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Genes

21 gene mutations causing the forebrain hypoplasia phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ARID1A AT rich interactive domain 1A (SWI-like)
ARNT aryl hydrocarbon receptor nuclear translocator
AXIN1 axin 1
CCNF cyclin F
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYCS cytochrome c, somatic
ERF Ets2 repressor factor
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
LHX2 LIM homeobox 2
LIAS lipoic acid synthetase
LRP6 low density lipoprotein receptor-related protein 6
MBOAT7 membrane bound O-acyltransferase domain containing 7
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NR2E1 nuclear receptor subfamily 2, group E, member 1
OTX2 orthodenticle homeobox 2
PHGDH phosphoglycerate dehydrogenase
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
SETD2 SET domain containing 2
TULP3 tubby like protein 3
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble