focal Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

467 genes co-occuring with the biological term focal in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AATF apoptosis antagonizing transcription factor
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABI1 abl-interactor 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ACE angiotensin I converting enzyme
ACTG1 actin gamma 1
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
ADAM15 ADAM metallopeptidase domain 15
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADRB2 adrenoceptor beta 2, surface
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AGO2 argonaute RISC catalytic component 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALOX15 arachidonate 15-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
AMACR alpha-methylacyl-CoA racemase
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANKRD28 ankyrin repeat domain 28
ANKRD30A ankyrin repeat domain 30A
ANTXR1 anthrax toxin receptor 1
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
APOE apolipoprotein E
APOL1 apolipoprotein L, 1
APP amyloid beta (A4) precursor protein
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARF6 ADP-ribosylation factor 6
ARHGAP21 Rho GTPase activating protein 21
ARHGAP24 Rho GTPase activating protein 24
ARHGAP31 Rho GTPase activating protein 31
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASIC1 acid sensing (proton gated) ion channel 1
ATG13 autophagy related 13
BAG3 BCL2-associated athanogene 3
BAX BCL2-associated X protein
BCAR1 breast cancer anti-estrogen resistance 1
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BDNF brain-derived neurotrophic factor
BMX BMX non-receptor tyrosine kinase
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA1 breast cancer 1, early onset
BSG basigin (Ok blood group)
C3 complement component 3
C9ORF72 chromosome 9 open reading frame 72
CA9 carbonic anhydrase IX
CALB2 calbindin 2
CALD1 caldesmon 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CAPN2 calpain 2, (m/II) large subunit
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CASS4 Cas scaffolding protein family member 4
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CD24 CD24 molecule
CD2AP CD2-associated protein
CD34 CD34 molecule
CD38 CD38 molecule
CD44 CD44 molecule (Indian blood group)
CD80 CD80 molecule
CD9 CD9 molecule
CD99 CD99 molecule
CDC42 cell division cycle 42
CDCP1 CUB domain containing protein 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDKL5 cyclin-dependent kinase-like 5
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX2 caudal type homeobox 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFH complement factor H
CFL1 cofilin 1 (non-muscle)
CHRM1 cholinergic receptor, muscarinic 1
CIB1 calcium and integrin binding 1 (calmyrin)
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
CLCN5 chloride channel, voltage-sensitive 5
CLDN1 claudin 1
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CNR1 cannabinoid receptor 1 (brain)
CNTNAP2 contactin associated protein-like 2
COL11A1 collagen, type XI, alpha 1
COL16A1 collagen, type XVI, alpha 1
COL1A1 collagen, type I, alpha 1
COL2A1 collagen, type II, alpha 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
COMP cartilage oligomeric matrix protein
COX2
CPA6 carboxypeptidase A6
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYBA cytochrome b-245, alpha polypeptide
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP26C1 cytochrome P450, family 26, subfamily C, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAPK3 death-associated protein kinase 3
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53
DEFB4A defensin, beta 4A
DEPDC5 DEP domain containing 5
DIAPH3 diaphanous-related formin 3
DIXDC1 DIX domain containing 1
DLC1 DLC1 Rho GTPase activating protein
DLGAP2 discs, large (Drosophila) homolog-associated protein 2
DMD dystrophin
DMPK dystrophia myotonica-protein kinase
DNM2 dynamin 2
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DOCK1 dedicator of cytokinesis 1
DPYSL3 dihydropyrimidinase-like 3
DRD5 dopamine receptor D5
EDNRA endothelin receptor type A
EDNRB endothelin receptor type B
EGF epidermal growth factor
EGFL7 EGF-like-domain, multiple 7
EGFR epidermal growth factor receptor
EIF3H eukaryotic translation initiation factor 3, subunit H
ENG endoglin
EPB41 erythrocyte membrane protein band 4.1
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
EYA1 EYA transcriptional coactivator and phosphatase 1
F2R coagulation factor II (thrombin) receptor
FAM107A family with sequence similarity 107, member A
FBN1 fibrillin 1
FER fer (fps/fes related) tyrosine kinase
FERMT1 fermitin family member 1
FERMT2 fermitin family member 2
FERMT3 fermitin family member 3
FGB fibrinogen beta chain
FGD1 FYVE, RhoGEF and PH domain containing 1
FGF10 fibroblast growth factor 10
FGF2 fibroblast growth factor 2 (basic)
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FHL2 four and a half LIM domains 2
FLNB filamin B, beta
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FOCAD focadhesin
FSCN1 fascin actin-bundling protein 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB2 GRB2-associated binding protein 2
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GATA2 GATA binding protein 2
GFAP glial fibrillary acidic protein
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GJA1 gap junction protein, alpha 1, 43kDa
GJB2 gap junction protein, beta 2, 26kDa
GLUL glutamate-ammonia ligase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GPC3 glypican 3
GRB7 growth factor receptor-bound protein 7
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GSK3B glycogen synthase kinase 3 beta
HDAC6 histone deacetylase 6
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSPB1 heat shock 27kDa protein 1
HSPG2 heparan sulfate proteoglycan 2
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IHH indian hedgehog
IL10 interleukin 10
IL17A interleukin 17A
IL17RA interleukin 17 receptor A
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL2 interleukin 2
IL24 interleukin 24
IL5 interleukin 5
IL6 interleukin 6
ILK integrin-linked kinase
INF2 inverted formin, FH2 and WH2 domain containing
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGA9 integrin, alpha 9
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB1BP1 integrin beta 1 binding protein 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KDR kinase insert domain receptor
KEAP1 kelch-like ECH-associated protein 1
KIF1C kinesin family member 1C
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT19 keratin 19, type I
KRT6A keratin 6A, type II
KRT6C keratin 6C, type II
KRT7 keratin 7, type II
LAMB2 laminin, beta 2 (laminin S)
LAMP2 lysosomal-associated membrane protein 2
LASP1 LIM and SH3 protein 1
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LIMD1 LIM domains containing 1
LIMS1 LIM and senescent cell antigen-like domains 1
LIMS2 LIM and senescent cell antigen-like domains 2
LMX1B LIM homeobox transcription factor 1, beta
LOX lysyl oxidase
LPAR1 lysophosphatidic acid receptor 1
LPP LIM domain containing preferred translocation partner in lipoma
LRP1 low density lipoprotein receptor-related protein 1
LRP1B low density lipoprotein receptor-related protein 1B
LTF lactotransferrin
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3
MAP2 microtubule-associated protein 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K5 mitogen-activated protein kinase kinase 5
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MIR138-1 microRNA 138-1
MIR141 microRNA 141
MIR186 microRNA 186
MIR200A microRNA 200a
MIR200B microRNA 200b
MIR200C microRNA 200c
MIR30A microRNA 30a
MIR383 microRNA 383
MIR429 microRNA 429
MISP mitotic spindle positioning
MLH1 mutL homolog 1
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYD88 myeloid differentiation primary response 88
MYH9 myosin, heavy chain 9, non-muscle
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYO1E myosin IE
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
MYOG myogenin (myogenic factor 4)
NCAM1 neural cell adhesion molecule 1
NCK2 NCK adaptor protein 2
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NEBL nebulette
NF2 neurofibromin 2 (merlin)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX4 NADPH oxidase 4
NPC2 Niemann-Pick disease, type C2
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRCAM neuronal cell adhesion molecule
NXF5 nuclear RNA export factor 5
PABPC1 poly(A) binding protein, cytoplasmic 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PANK2 pantothenate kinase 2
PARVA parvin, alpha
PARVB parvin, beta
PCDH19 protocadherin 19
PDGFA platelet-derived growth factor alpha polypeptide
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PEAK1 pseudopodium-enriched atypical kinase 1
PGR progesterone receptor
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLCE1 phospholipase C, epsilon 1
PLEC plectin
PLK1 polo-like kinase 1
PNKD paroxysmal nonkinesigenic dyskinesia
PODXL podocalyxin-like
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POLG polymerase (DNA directed), gamma
PORCN porcupine homolog (Drosophila)
POSTN periostin, osteoblast specific factor
POU5F1 POU class 5 homeobox 1
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKD1 protein kinase D1
PRKG1 protein kinase, cGMP-dependent, type I
PRNP prion protein
PRUNE prune exopolyphosphatase
PSEN1 presenilin 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTK6 protein tyrosine kinase 6
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRU protein tyrosine phosphatase, receptor type, U
PVR poliovirus receptor
PXN paxillin
RAB5A RAB5A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAP1A RAP1A, member of RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RAVER1 ribonucleoprotein, PTB-binding 1
RB1 retinoblastoma 1
RB1CC1 RB1-inducible coiled-coil 1
RELN reelin
RET ret proto-oncogene
RGS1 regulator of G-protein signaling 1
RHOA ras homolog family member A
RHOD ras homolog family member D
RHOJ ras homolog family member J
RHOU ras homolog family member U
RND3 Rho family GTPase 3
RNF14 ring finger protein 14
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RRAS related RAS viral (r-ras) oncogene homolog
RRM1 ribonucleotide reductase M1
RTKN rhotekin
RYR1 ryanodine receptor 1 (skeletal)
S100A4 S100 calcium binding protein A4
S100B S100 calcium binding protein B
S100P S100 calcium binding protein P
SALL4 spalt-like transcription factor 4
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN3A sodium channel, voltage gated, type III alpha subunit
SDC4 syndecan 4
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SH2D3C SH2 domain containing 3C
SHH sonic hedgehog
SIGLEC9 sialic acid binding Ig-like lectin 9
SKAP2 src kinase associated phosphoprotein 2
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC16A4 solute carrier family 16, member 4
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SNAI1 snail family zinc finger 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNRPE small nuclear ribonucleoprotein polypeptide E
SNX27 sorting nexin family member 27
SOCS1 suppressor of cytokine signaling 1
SOD1 superoxide dismutase 1, soluble
SORBS3 sorbin and SH3 domain containing 3
SOX2 SRY (sex determining region Y)-box 2
SPAST spastin
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
SSTR2 somatostatin receptor 2
STARD13 StAR-related lipid transfer (START) domain containing 13
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STEAP4 STEAP family member 4
STK11 serine/threonine kinase 11
SUMO1 small ubiquitin-like modifier 1
SYK spleen tyrosine kinase
SYNE1 spectrin repeat containing, nuclear envelope 1
SYNPO synaptopodin
TBC1D24 TBC1 domain family, member 24
TES testin LIM domain protein
TF transferrin
TGFB1 transforming growth factor, beta 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
THAP1 THAP domain containing, apoptosis associated protein 1
THBS1 thrombospondin 1
THSD1 thrombospondin, type I, domain containing 1
TIMP4 TIMP metallopeptidase inhibitor 4
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLN1 talin 1
TLR2 toll-like receptor 2
TMBIM4 transmembrane BAX inhibitor motif containing 4
TNC tenascin C
TNF tumor necrosis factor
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy
TNS2 tensin 2
TNS3 tensin 3
TNS4 tensin 4
TOR1A torsin family 1, member A (torsin A)
TP53 tumor protein p53
TP63 tumor protein p63
TRIP6 thyroid hormone receptor interactor 6
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TWIST2 twist family bHLH transcription factor 2
ULK1 unc-51 like autophagy activating kinase 1
VAMP7 vesicle-associated membrane protein 7
VASP vasodilator-stimulated phosphoprotein
VCAM1 vascular cell adhesion molecule 1
VCL vinculin
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VIM vimentin
VPREB1 pre-B lymphocyte 1
VTN vitronectin
WNT1 wingless-type MMTV integration site family, member 1
WT1 Wilms tumor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZFYVE21 zinc finger, FYVE domain containing 21
ZYX zyxin