focal adhesion Gene Set

Dataset KEGG Pathways
Category structural or functional annotations
Type pathway
Description Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. (Gene Ontology, GO_0005925)
External Link http://www.genome.jp/kegg/pathway/hsa/hsa04510.html
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Genes

192 proteins participating in the focal adhesion pathway from the KEGG Pathways dataset.

Symbol Name
ACTB actin, beta
ACTG1 actin gamma 1
ACTN1 actinin, alpha 1
ACTN2 actinin, alpha 2
ACTN3 actinin, alpha 3 (gene/pseudogene)
ACTN4 actinin, alpha 4
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ARHGAP5 Rho GTPase activating protein 5
BAD BCL2-associated agonist of cell death
BCAR1 breast cancer anti-estrogen resistance 1
BCL2 B-cell CLL/lymphoma 2
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
CAPN2 calpain 2, (m/II) large subunit
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CAV3 caveolin 3
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CDC42 cell division cycle 42
CHAD chondroadherin
COL11A1 collagen, type XI, alpha 1
COL11A2 collagen, type XI, alpha 2
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL2A1 collagen, type II, alpha 1
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A4 collagen, type IV, alpha 4
COL4A6 collagen, type IV, alpha 6
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COL5A3 collagen, type V, alpha 3
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COL6A6 collagen, type VI, alpha 6
COMP cartilage oligomeric matrix protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DIAPH1 diaphanous-related formin 1
DOCK1 dedicator of cytokinesis 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ELK1 ELK1, member of ETS oncogene family
ERBB2 erb-b2 receptor tyrosine kinase 2
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FLNA filamin A, alpha
FLNB filamin B, beta
FLNC filamin C, gamma
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GRB2 growth factor receptor-bound protein 2
GSK3B glycogen synthase kinase 3 beta
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HRAS Harvey rat sarcoma viral oncogene homolog
IBSP integrin-binding sialoprotein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
ILK integrin-linked kinase
ITGA1 integrin, alpha 1
ITGA10 integrin, alpha 10
ITGA11 integrin, alpha 11
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGA7 integrin, alpha 7
ITGA8 integrin, alpha 8
ITGA9 integrin, alpha 9
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
ITGB6 integrin, beta 6
ITGB7 integrin, beta 7
ITGB8 integrin, beta 8
JUN jun proto-oncogene
KDR kinase insert domain receptor
LAMA1 laminin, alpha 1
LAMA2 laminin, alpha 2
LAMA3 laminin, alpha 3
LAMA4 laminin, alpha 4
LAMA5 laminin, alpha 5
LAMB1 laminin, beta 1
LAMB2 laminin, beta 2 (laminin S)
LAMB3 laminin, beta 3
LAMB4 laminin, beta 4
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMC2 laminin, gamma 2
LAMC3 laminin, gamma 3
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MET MET proto-oncogene, receptor tyrosine kinase
MYL2 myosin, light chain 2, regulatory, cardiac, slow
MYL5 myosin, light chain 5, regulatory
MYL7 myosin, light chain 7, regulatory
MYL8P myosin, light chain 8, pseudogene
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
MYLK2 myosin light chain kinase 2
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PARVA parvin, alpha
PARVB parvin, beta
PARVG parvin, gamma
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PDPK1 3-phosphoinositide dependent protein kinase 1
PGF placental growth factor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PRKCA protein kinase C, alpha
PRKCG protein kinase C, gamma
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1
RELN reelin
RHOA ras homolog family member A
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SHC4 SHC (Src homology 2 domain containing) family, member 4
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THBS3 thrombospondin 3
THBS4 thrombospondin 4
TLN1 talin 1
TLN2 talin 2
TNC tenascin C
TNN tenascin N
TNR tenascin R
TNXB tenascin XB
VASP vasodilator-stimulated phosphoprotein
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VCL vinculin
VEGFA vascular endothelial growth factor A
VEGFB vascular endothelial growth factor B
VEGFC vascular endothelial growth factor C
VTN vitronectin
VWF von Willebrand factor
ZYX zyxin