focal adhesion Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. (Gene Ontology, GO_0005925)
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Genes

584 proteins co-occuring with the focal adhesion cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
PXN paxillin 3.73063
VCL vinculin 3.07973
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.74599
FN1 fibronectin 1 2.63746
PTK2 protein tyrosine kinase 2 2.48293
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.14132
PTK2B protein tyrosine kinase 2 beta 1.99333
ZYX zyxin 1.92368
ILK integrin-linked kinase 1.91882
BCAR1 breast cancer anti-estrogen resistance 1 1.9084
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.83203
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 1.82524
CRK v-crk avian sarcoma virus CT10 oncogene homolog 1.78058
TNS1 tensin 1 1.77144
SEBOX SEBOX homeobox 1.77015
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.65393
CDC42 cell division cycle 42 1.64015
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.50057
SDC4 syndecan 4 1.47627
VASP vasodilator-stimulated phosphoprotein 1.47118
PTPN12 protein tyrosine phosphatase, non-receptor type 12 1.43839
FERMT1 fermitin family member 1 1.42092
CSK c-src tyrosine kinase 1.4069
GRB2 growth factor receptor-bound protein 2 1.38905
ITGB6 integrin, beta 6 1.37464
MMP2 matrix metallopeptidase 2 1.36857
ITGB7 integrin, beta 7 1.33522
ITGB8 integrin, beta 8 1.33359
FYN FYN proto-oncogene, Src family tyrosine kinase 1.33304
FERMT2 fermitin family member 2 1.32384
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 1.30873
ITGB4 integrin, beta 4 1.29692
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 1.2905
TLN1 talin 1 1.28729
GRB7 growth factor receptor-bound protein 7 1.26815
MMP9 matrix metallopeptidase 9 1.26075
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.24707
PARVA parvin, alpha 1.23296
DLC1 DLC1 Rho GTPase activating protein 1.2314
PTPRD protein tyrosine phosphatase, receptor type, D 1.2314
CTTN cortactin 1.2288
ARHGAP35 Rho GTPase activating protein 35 1.19983
EGFR epidermal growth factor receptor 1.1988
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 1.19674
PTEN phosphatase and tensin homolog 1.19468
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.18697
DNM2 dynamin 2 1.16081
TRIP6 thyroid hormone receptor interactor 6 1.13216
JUN jun proto-oncogene 1.12909
TNS2 tensin 2 1.1046
GRP gastrin-releasing peptide 1.09086
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 1.07613
PTPN3 protein tyrosine phosphatase, non-receptor type 3 1.07562
TNS4 tensin 4 1.0741
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 1.06701
BCAR3 breast cancer anti-estrogen resistance 3 1.06195
MAPK3 mitogen-activated protein kinase 3 1.05589
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 1.05287
MSN moesin 1.04733
PLAU plasminogen activator, urokinase 1.0418
PARVB parvin, beta 1.03529
RB1CC1 RB1-inducible coiled-coil 1 1.03428
EZR ezrin 1.01635
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 1.01536
LPP LIM domain containing preferred translocation partner in lipoma 1.00892
ITGAV integrin, alpha V 1.00005
SPP1 secreted phosphoprotein 1 0.99956
LHX3 LIM homeobox 3 0.999068
CD44 CD44 molecule (Indian blood group) 0.988294
DOCK1 dedicator of cytokinesis 1 0.983906
THBS1 thrombospondin 1 0.980501
TGFB1 transforming growth factor, beta 1 0.978559
PKN1 protein kinase N1 0.976619
CAV1 caveolin 1, caveolae protein, 22kDa 0.976619
RDX radixin 0.968884
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.947808
EPHA2 EPH receptor A2 0.943533
MET MET proto-oncogene, receptor tyrosine kinase 0.938795
TNC tenascin C 0.924197
LPXN leupaxin 0.917644
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.90646
LASP1 LIM and SH3 protein 1 0.905996
VEGFA vascular endothelial growth factor A 0.898109
KDR kinase insert domain receptor 0.893943
ARHGAP1 Rho GTPase activating protein 1 0.89348
MYLK myosin light chain kinase 0.889321
STARD13 StAR-related lipid transfer (START) domain containing 13 0.876869
CCND1 cyclin D1 0.866287
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.86169
SAR1A secretion associated, Ras related GTPase 1A 0.86077
FERMT3 fermitin family member 3 0.859852
ZHX2 zinc fingers and homeoboxes 2 0.857095
LIMS2 LIM and senescent cell antigen-like domains 2 0.855257
IGF1 insulin-like growth factor 1 (somatomedin C) 0.85388
LIMS3 LIM and senescent cell antigen-like domains 3 0.845155
RHOB ras homolog family member B 0.833679
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.831843
RAP2B RAP2B, member of RAS oncogene family 0.82863
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.820829
ARF3 ADP-ribosylation factor 3 0.819911
ARHGAP18 Rho GTPase activating protein 18 0.819452
RAB1B RAB1B, member RAS oncogene family 0.816699
LYN LYN proto-oncogene, Src family tyrosine kinase 0.812111
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 0.8089
ERBB2 erb-b2 receptor tyrosine kinase 2 0.807982
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.801104
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.801104
FGF2 fibroblast growth factor 2 (basic) 0.800645
PALLD palladin, cytoskeletal associated protein 0.800187
CIB1 calcium and integrin binding 1 (calmyrin) 0.789649
CXCL12 chemokine (C-X-C motif) ligand 12 0.787817
MAPK8 mitogen-activated protein kinase 8 0.779583
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.770451
TP53 tumor protein p53 0.76726
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.765438
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.754983
CDH5 cadherin 5, type 2 (vascular endothelium) 0.752263
IGF1R insulin-like growth factor 1 receptor 0.746833
ZFYVE21 zinc finger, FYVE domain containing 21 0.741416
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.740515
ACTN4 actinin, alpha 4 0.723026
MAPK14 mitogen-activated protein kinase 14 0.715458
NCK2 NCK adaptor protein 2 0.710579
FLNA filamin A, alpha 0.710579
LAMB2 laminin, beta 2 (laminin S) 0.707482
GRPR gastrin-releasing peptide receptor 0.705714
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.702626
MAPK1 mitogen-activated protein kinase 1 0.698663
PFN1 profilin 1 0.697784
EFNA1 ephrin-A1 0.693832
PARVG parvin, gamma 0.693832
TNS3 tensin 3 0.693393
ROCK1P1 Rho-associated, coiled-coil containing protein kinase 1 pseudogene 1 0.692516
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 0.685517
MAPK11 mitogen-activated protein kinase 11 0.683335
SYK spleen tyrosine kinase 0.679849
FLT4 fms-related tyrosine kinase 4 0.678978
MBTPS1 membrane-bound transcription factor peptidase, site 1 0.676803
PTS 6-pyruvoyltetrahydropterin synthase 0.668992
PLEK pleckstrin 0.665529
SORBS1 sorbin and SH3 domain containing 1 0.664664
JAK2 Janus kinase 2 0.662072
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.659913
VCAM1 vascular cell adhesion molecule 1 0.65001
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.648291
IRS1 insulin receptor substrate 1 0.648291
ICAM1 intercellular adhesion molecule 1 0.647003
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.647003
IBSP integrin-binding sialoprotein 0.645287
CDKN2A cyclin-dependent kinase inhibitor 2A 0.639289
KLF8 Kruppel-like factor 8 0.638861
HRAS Harvey rat sarcoma viral oncogene homolog 0.634586
TGM2 transglutaminase 2 0.632878
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.626483
ZNF384 zinc finger protein 384 0.626483
PFN2 profilin 2 0.624781
ITGA6 integrin, alpha 6 0.62393
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.61883
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.612895
VAV2 vav 2 guanine nucleotide exchange factor 0.609086
FOS FBJ murine osteosarcoma viral oncogene homolog 0.605706
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.601909
PFN4 profilin family, member 4 0.598117
FLT1 fms-related tyrosine kinase 1 0.596014
ITGB1BP1 integrin beta 1 binding protein 1 0.594753
SDC1 syndecan 1 0.593492
GSN gelsolin 0.591812
LIMS1 LIM and senescent cell antigen-like domains 1 0.587618
CTGF connective tissue growth factor 0.586361
PLG plasminogen 0.585942
CD151 CD151 molecule (Raph blood group) 0.585105
RSU1 Ras suppressor protein 1 0.583849
INPPL1 inositol polyphosphate phosphatase-like 1 0.581758
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.577581
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.577581
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.572578
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.57008
BGLAP bone gamma-carboxyglutamate (gla) protein 0.568416
TM4SF5 transmembrane 4 L six family member 5 0.566338
GRB14 growth factor receptor-bound protein 14 0.565923
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.564677
CALR calreticulin 0.563017
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.558457
TNF tumor necrosis factor 0.558457
SMAD2 SMAD family member 2 0.557214
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 0.54606
EDN1 endothelin 1 0.542352
INS insulin 0.53906
SORBS2 sorbin and SH3 domain containing 2 0.538238
CD9 CD9 molecule 0.537827
CDK20 cyclin-dependent kinase 20 0.537005
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.530847
NPHP1 nephronophthisis 1 (juvenile) 0.527569
CAST calpastatin 0.527569
EFS embryonal Fyn-associated substrate 0.52716
TLN2 talin 2 0.520615
SHB Src homology 2 domain containing adaptor protein B 0.518573
CALD1 caldesmon 1 0.51694
ESR1 estrogen receptor 1 0.514085
NEBL nebulette 0.511233
CTNND1 catenin (cadherin-associated protein), delta 1 0.511233
TYRO3 TYRO3 protein tyrosine kinase 0.510826
NRP1 neuropilin 1 0.509197
TPM1 tropomyosin 1 (alpha) 0.50757
WASL Wiskott-Aldrich syndrome-like 0.506757
LIMK1 LIM domain kinase 1 0.500258
TJP1 tight junction protein 1 0.499447
VAV1 vav 1 guanine nucleotide exchange factor 0.499042
FSCN1 fascin actin-bundling protein 1 0.497015
ARHGAP31 Rho GTPase activating protein 31 0.49661
SDC2 syndecan 2 0.49661
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.496205
GSTA1 glutathione S-transferase alpha 1 0.4958
F2R coagulation factor II (thrombin) receptor 0.493371
TES testin LIM domain protein 0.491348
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.487711
CYR61 cysteine-rich, angiogenic inducer, 61 0.487307
ALPPL2 alkaline phosphatase, placental-like 2 0.487307
RUNX2 runt-related transcription factor 2 0.487307
GSTA3 glutathione S-transferase alpha 3 0.4865
ALPL alkaline phosphatase, liver/bone/kidney 0.4865
ALPP alkaline phosphatase, placental 0.4865
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 0.486096
GSTA2 glutathione S-transferase alpha 2 0.484483
GSTA4 glutathione S-transferase alpha 4 0.484483
FOCAD focadhesin 0.483273
KNG1 kininogen 1 0.481258
PLCG1 phospholipase C, gamma 1 0.47844
FHL2 four and a half LIM domains 2 0.470005
EPHB4 EPH receptor B4 0.468401
ALB albumin 0.465998
RHOJ ras homolog family member J 0.465598
MMP13 matrix metallopeptidase 13 0.464798
TIMP2 TIMP metallopeptidase inhibitor 2 0.462398
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.460001
MARCKS myristoylated alanine-rich protein kinase C substrate 0.457208
EGFL6 EGF-like-domain, multiple 6 0.45641
FGF1 fibroblast growth factor 1 (acidic) 0.45641
LIM2 lens intrinsic membrane protein 2, 19kDa 0.454816
INSR insulin receptor 0.453223
CAPN2 calpain 2, (m/II) large subunit 0.452825
MMP1 matrix metallopeptidase 1 0.449245
LCK LCK proto-oncogene, Src family tyrosine kinase 0.448848
RRAS related RAS viral (r-ras) oncogene homolog 0.444878
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 0.444482
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 0.444085
MARK2 MAP/microtubule affinity-regulating kinase 2 0.441708
AJUBA ajuba LIM protein 0.439728
ZER1 zyg-11 related, cell cycle regulator 0.438542
BMX BMX non-receptor tyrosine kinase 0.438146
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 0.43617
SMAD3 SMAD family member 3 0.43538
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.434985
ERBB3 erb-b2 receptor tyrosine kinase 3 0.430253
GRB10 growth factor receptor-bound protein 10 0.428284
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.427497
EPHB2 EPH receptor B2 0.427104
EPHA1 EPH receptor A1 0.426318
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.426318
MMP7 matrix metallopeptidase 7 0.41886
PI3 peptidase inhibitor 3, skin-derived 0.41886
ACTA1 actin, alpha 1, skeletal muscle 0.418077
NET1 neuroepithelial cell transforming 1 0.417685
CXCR4 chemokine (C-X-C motif) receptor 4 0.415728
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.414946
PTPRH protein tyrosine phosphatase, receptor type, H 0.413773
ACTB actin, beta 0.413382
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.41143
EPB41 erythrocyte membrane protein band 4.1 0.408699
SDCBP syndecan binding protein (syntenin) 0.408699
RND3 Rho family GTPase 3 0.408699
CCKBR cholecystokinin B receptor 0.408309
FHL1 four and a half LIM domains 1 0.40247
GP6 glycoprotein VI (platelet) 0.402081
ITGB5 integrin, beta 5 0.399363
MYLK3 myosin light chain kinase 3 0.397811
TTC9 tetratricopeptide repeat domain 9 0.39626
PARP1 poly (ADP-ribose) polymerase 1 0.395873
NTN1 netrin 1 0.395098
CFL1 cofilin 1 (non-muscle) 0.39471
NPS neuropeptide S 0.392001
TIMP1 TIMP metallopeptidase inhibitor 1 0.390841
MIR197 microRNA 197 0.390455
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.388909
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 0.388137
PRKD3 protein kinase D3 0.385051
ACTN1 actinin, alpha 1 0.381584
NOV nephroblastoma overexpressed 0.381584
RET ret proto-oncogene 0.378507
ANKRD28 ankyrin repeat domain 28 0.378122
TGFB1I1 transforming growth factor beta 1 induced transcript 1 0.378122
GSK3B glycogen synthase kinase 3 beta 0.375818
DIXDC1 DIX domain containing 1 0.371982
LOX lysyl oxidase 0.371216
MMP3 matrix metallopeptidase 3 0.371216
EGFL7 EGF-like-domain, multiple 7 0.370833
STK4 serine/threonine kinase 4 0.367771
NEO1 neogenin 1 0.367388
LIMD1 LIM domains containing 1 0.367388
PRPF4B pre-mRNA processing factor 4B 0.365477
MYOCD myocardin 0.36204
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.361277
CD82 CD82 molecule 0.361277
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.360896
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.35899
TMSB4X thymosin beta 4, X-linked 0.358609
SIRPA signal-regulatory protein alpha 0.358228
CCR1 chemokine (C-C motif) receptor 1 0.357467
TLK1 tousled-like kinase 1 0.357467
GAST gastrin 0.357086
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.356705
S100A4 S100 calcium binding protein A4 0.354422
ATG13 autophagy related 13 0.354042
FBN1 fibrillin 1 0.353662
COL18A1 collagen, type XVIII, alpha 1 0.351762
ITGA1 integrin, alpha 1 0.351382
ITGA8 integrin, alpha 8 0.351002
RECK reversion-inducing-cysteine-rich protein with kazal motifs 0.349863
ESAM endothelial cell adhesion molecule 0.349863
NOS3 nitric oxide synthase 3 (endothelial cell) 0.347208
ACTG1 actin gamma 1 0.346829
WNT5A wingless-type MMTV integration site family, member 5A 0.346829
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4 0.346071
ISL1 ISL LIM homeobox 1 0.344556
TESK1 testis-specific kinase 1 0.343799
PDCD10 programmed cell death 10 0.343421
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.342285
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.342285
NF2 neurofibromin 2 (merlin) 0.342285
EVL Enah/Vasp-like 0.341529
PHACTR4 phosphatase and actin regulator 4 0.338506
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.337751
RABL3 RAB, member of RAS oncogene family-like 3 0.333979
FGR FGR proto-oncogene, Src family tyrosine kinase 0.331719
NELL1 NEL-like 1 (chicken) 0.331342
RTKN rhotekin 0.330589
DMD dystrophin 0.329084
BMP2 bone morphogenetic protein 2 0.328708
RAVER1 ribonucleoprotein, PTB-binding 1 0.328332
PEPD peptidase D 0.326829
STK25 serine/threonine kinase 25 0.326078
RHOA ras homolog family member A 0.32345
DAP death-associated protein 0.323075
EPS8 epidermal growth factor receptor pathway substrate 8 0.3227
ULK1 unc-51 like autophagy activating kinase 1 0.3227
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.32195
PDGFB platelet-derived growth factor beta polypeptide 0.321575
COL1A1 collagen, type I, alpha 1 0.321201
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.318205
MAPK7 mitogen-activated protein kinase 7 0.316708
THY1 Thy-1 cell surface antigen 0.316708
MAP2K1 mitogen-activated protein kinase kinase 1 0.315212
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.313718
HCK HCK proto-oncogene, Src family tyrosine kinase 0.313718
ANK1 ankyrin 1, erythrocytic 0.311105
FMN1 formin 1 0.309613
SRCIN1 SRC kinase signaling inhibitor 1 0.308867
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.308494
ANGPT2 angiopoietin 2 0.306632
ANXA5 annexin A5 0.305888
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 0.304027
RHOBTB2 Rho-related BTB domain containing 2 0.303283
DDR1 discoidin domain receptor tyrosine kinase 1 0.302912
NRP2 neuropilin 2 0.30254
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.30254
COL13A1 collagen, type XIII, alpha 1 0.302168
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 0.302168
CD47 CD47 molecule 0.301797
LGI3 leucine-rich repeat LGI family, member 3 0.300682
ADAM12 ADAM metallopeptidase domain 12 0.300311
MIR95 microRNA 95 0.299197
KRAS Kirsten rat sarcoma viral oncogene homolog 0.298455
ARF6 ADP-ribosylation factor 6 0.29623
NOX1 NADPH oxidase 1 0.295489
FLNB filamin B, beta 0.294748
TYK2 tyrosine kinase 2 0.291047
WAS Wiskott-Aldrich syndrome 0.288829
SCARA5 scavenger receptor class A, member 5 0.28846
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.286614
TNK2 tyrosine kinase, non-receptor, 2 0.285876
ARHGAP10 Rho GTPase activating protein 10 0.285507
IL1B interleukin 1, beta 0.282926
SOS1 son of sevenless homolog 1 (Drosophila) 0.282558
AXL AXL receptor tyrosine kinase 0.282558
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.281453
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.27998
MCF2 MCF.2 cell line derived transforming sequence 0.27998
TIAM1 T-cell lymphoma invasion and metastasis 1 0.278877
RAP1A RAP1A, member of RAS oncogene family 0.278141
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.278141
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.277038
SYNM synemin, intermediate filament protein 0.276671
CDK2 cyclin-dependent kinase 2 0.273734
FGFR2 fibroblast growth factor receptor 2 0.272633
BSG basigin (Ok blood group) 0.271533
MERTK MER proto-oncogene, tyrosine kinase 0.270068
OCLN occludin 0.269701
BST1 bone marrow stromal cell antigen 1 0.268969
LGALS3 lectin, galactoside-binding, soluble, 3 0.268969
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E 0.268969
IL32 interleukin 32 0.266774
NGF nerve growth factor (beta polypeptide) 0.266774
LOXL2 lysyl oxidase-like 2 0.264215
CSPG4 chondroitin sulfate proteoglycan 4 0.26385
CXCL8 chemokine (C-X-C motif) ligand 8 0.259109
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 0.259109
AR androgen receptor 0.258381
CDCP1 CUB domain containing protein 1 0.258016
LMO7 LIM domain 7 0.256197
EPHA3 EPH receptor A3 0.255834
MYOM1 myomesin 1 0.25547
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.255107
MAPK9 mitogen-activated protein kinase 9 0.253653
IQGAP1 IQ motif containing GTPase activating protein 1 0.251476
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 0.250751
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.250389
UTRN utrophin 0.250026
MARK3 MAP/microtubule affinity-regulating kinase 3 0.247854
EFNB2 ephrin-B2 0.247854
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.246407
LPAR2 lysophosphatidic acid receptor 2 0.246046
IRS2 insulin receptor substrate 2 0.245685
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.245685
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.243879
STARD8 StAR-related lipid transfer (START) domain containing 8 0.243158
MIR15B microRNA 15b 0.242437
MACF1 microtubule-actin crosslinking factor 1 0.242076
RPSA ribosomal protein SA 0.241356
LAMA5 laminin, alpha 5 0.239916
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.239916
FBLIM1 filamin binding LIM protein 1 0.239916
PGR progesterone receptor 0.238478
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.238119
TMIGD2 transmembrane and immunoglobulin domain containing 2 0.238119
CPNE3 copine III 0.237401
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.237042
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.237042
DCN decorin 0.235607
ANKRD13A ankyrin repeat domain 13A 0.235249
RHOU ras homolog family member U 0.234174
CDK5 cyclin-dependent kinase 5 0.233459
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.230958
HRG histidine-rich glycoprotein 0.230601
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.229888
ARHGAP30 Rho GTPase activating protein 30 0.229888
CDK4 cyclin-dependent kinase 4 0.228464
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.228464
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.228108
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.228108
TENM4 teneurin transmembrane protein 4 0.227397
GJA1 gap junction protein, alpha 1, 43kDa 0.227041
SLK STE20-like kinase 0.225976
EPHA5 EPH receptor A5 0.223497
FLNC filamin C, gamma 0.223143
GRAP2 GRB2-related adaptor protein 2 0.22279
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.222436
PF4 platelet factor 4 0.22173
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.22173
BAX BCL2-associated X protein 0.220673
EDNRB endothelin receptor type B 0.220321
EPHA4 EPH receptor A4 0.219969
VWF von Willebrand factor 0.218914
CRIP2 cysteine-rich protein 2 0.217861
KLHL11 kelch-like family member 11 0.217861
RHOD ras homolog family member D 0.21681
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.21681
MAP2K7 mitogen-activated protein kinase kinase 7 0.215063
PGM5 phosphoglucomutase 5 0.214366
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.214017
CCNB1 cyclin B1 0.214017
LAYN layilin 0.213322
SFTPA2 surfactant protein A2 0.212974
GPR52 G protein-coupled receptor 52 0.21228
AMER2 APC membrane recruitment protein 2 0.21228
FSCN3 fascin actin-bundling protein 3, testicular 0.211587
BCL2L1 BCL2-like 1 0.210894
HBEGF heparin-binding EGF-like growth factor 0.210549
CTHRC1 collagen triple helix repeat containing 1 0.210203
BHLHE22 basic helix-loop-helix family, member e22 0.209858
PKD1P6 polycystic kidney disease 1 (autosomal dominant) pseudogene 6 0.208481
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.208481
MIR223 microRNA 223 0.207108
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 0.207108
PLK4 polo-like kinase 4 0.206423
COL3A1 collagen, type III, alpha 1 0.206082
EFNB3 ephrin-B3 0.205399
ARF5 ADP-ribosylation factor 5 0.204718
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.203361
BIRC5 baculoviral IAP repeat containing 5 0.202346
POSTN periostin, osteoblast specific factor 0.201672
ARHGAP11A Rho GTPase activating protein 11A 0.200663
NCKIPSD NCK interacting protein with SH3 domain 0.200663
PPP6C protein phosphatase 6, catalytic subunit 0.200328
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.199993
NOX4 NADPH oxidase 4 0.199325
FSCN2 fascin actin-bundling protein 2, retinal 0.199325
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.198658
JUP junction plakoglobin 0.198325
PPP5C protein phosphatase 5, catalytic subunit 0.195353
NHSL2 NHS-like 2 0.195353
NHSL1 NHS-like 1 0.195353
NUDT16L1 nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 0.195353
DCC DCC netrin 1 receptor 0.195025
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.194371
EPHA7 EPH receptor A7 0.194371
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.1921
PLAT plasminogen activator, tissue 0.191777
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.191456
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 0.190175
PLXNC1 plexin C1 0.188905
CASP6 caspase 6, apoptosis-related cysteine peptidase 0.188905
TIAM2 T-cell lymphoma invasion and metastasis 2 0.188905
EIF4E eukaryotic translation initiation factor 4E 0.187646
SELE selectin E 0.186397
TESK2 testis-specific kinase 2 0.185469
ANXA2 annexin A2 0.184853
THSD7A thrombospondin, type I, domain containing 7A 0.184853
DMTF1 cyclin D binding myb-like transcription factor 1 0.183935
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.183328
FBLN2 fibulin 2 0.183025
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.182723
FBLN7 fibulin 7 0.18093
WISP1 WNT1 inducible signaling pathway protein 1 0.180339
NEB nebulin 0.180045
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 0.179752
SLC16A11 solute carrier family 16, member 11 0.179752
CAPNS1 calpain, small subunit 1 0.179167
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 0.179167
PPEF1 protein phosphatase, EF-hand calcium binding domain 1 0.178588
CD34 CD34 molecule 0.178011
PNMA6A paraneoplastic Ma antigen family member 6A 0.177439
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.176587
HAS2 hyaluronan synthase 2 0.176587
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.176305
FGFR3 fibroblast growth factor receptor 3 0.176024
TRIM15 tripartite motif containing 15 0.175745
ZDHHC1 zinc finger, DHHC-type containing 1 0.174087
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.173814
CCL4 chemokine (C-C motif) ligand 4 0.173543
EPHB1 EPH receptor B1 0.173003
AMER3 APC membrane recruitment protein 3 0.173003
ATG101 autophagy related 101 0.172468
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.17141
RB1 retinoblastoma 1 0.171149
ITGA7 integrin, alpha 7 0.170888
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.170629
CSRP2 cysteine and glycine-rich protein 2 0.170629
ARF1 ADP-ribosylation factor 1 0.170371
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.170114
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.169859
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.169859
SVIL supervillin 0.168598
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.167856
LAMA3 laminin, alpha 3 0.167856
PNPLA5 patatin-like phospholipase domain containing 5 0.167125
LDB2 LIM domain binding 2 0.167125
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.166405
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.166167
F11R F11 receptor 0.166167
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.165932
KCNH1 potassium channel, voltage gated eag related subfamily H, member 1 0.165932
PVR poliovirus receptor 0.165697
SPDEF SAM pointed domain containing ETS transcription factor 0.165231
ALOX5AP arachidonate 5-lipoxygenase-activating protein 0.164089
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 0.163865
FRK fyn-related Src family tyrosine kinase 0.163641
CAV2 caveolin 2 0.163641
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.16233
SFRP4 secreted frizzled-related protein 4 0.16233
FGF7 fibroblast growth factor 7 0.161275
ERBB4 erb-b2 receptor tyrosine kinase 4 0.160456
PODXL podocalyxin-like 0.160456
JAK1 Janus kinase 1 0.160254
COL5A2 collagen, type V, alpha 2 0.160053
SH2D3C SH2 domain containing 3C 0.160053
PNCK pregnancy up-regulated nonubiquitous CaM kinase 0.158882
TSC2 tuberous sclerosis 2 0.158129
CXCR1 chemokine (C-X-C motif) receptor 1 0.158129
PLXND1 plexin D1 0.158129
LPAR6 lysophosphatidic acid receptor 6 0.157943
ADAM15 ADAM metallopeptidase domain 15 0.157943
PTPRU protein tyrosine phosphatase, receptor type, U 0.157397
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.157397
IL6 interleukin 6 0.156688