fluphenazine-5597 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the fluphenazine-5597 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
AKAP8L A kinase (PRKA) anchor protein 8-like
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BARX2 BARX homeobox 2
C1ORF54 chromosome 1 open reading frame 54
C3 complement component 3
CA5B carbonic anhydrase VB, mitochondrial
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCDC57 coiled-coil domain containing 57
CCDC64 coiled-coil domain containing 64
CCNG2 cyclin G2
CCNK cyclin K
CD53 CD53 molecule
CDC14A cell division cycle 14A
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CLCN6 chloride channel, voltage-sensitive 6
CLEC4E C-type lectin domain family 4, member E
COL1A1 collagen, type I, alpha 1
COL7A1 collagen, type VII, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CSF1R colony stimulating factor 1 receptor
CSHL1 chorionic somatomammotropin hormone-like 1
DIAPH2-AS1 DIAPH2 antisense RNA 1
EPX eosinophil peroxidase
ERO1LB ERO1-like beta (S. cerevisiae)
ESR1 estrogen receptor 1
FAM66D family with sequence similarity 66, member D
FCMR Fc fragment of IgM receptor
FXYD2 FXYD domain containing ion transport regulator 2
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GJA9 gap junction protein, alpha 9, 59kDa
GPR85 G protein-coupled receptor 85
GPSM3 G-protein signaling modulator 3
GRB10 growth factor receptor-bound protein 10
HAO2 hydroxyacid oxidase 2 (long chain)
HOXB5 homeobox B5
HOXB6 homeobox B6
HPCA hippocalcin
HR hair growth associated
HYAL3 hyaluronoglucosaminidase 3
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KIAA0485 uncharacterized LOC57235
KLHL24 kelch-like family member 24
KRTAP2-4 keratin associated protein 2-4
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LENEP lens epithelial protein
LINC00341 long intergenic non-protein coding RNA 341
LPIN1 lipin 1
LRP12 low density lipoprotein receptor-related protein 12
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOB monoamine oxidase B
MAP2 microtubule-associated protein 2
MPZ myelin protein zero
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MXD4 MAX dimerization protein 4
NKTR natural killer cell triggering receptor
NNAT neuronatin
NR4A3 nuclear receptor subfamily 4, group A, member 3
NR6A1 nuclear receptor subfamily 6, group A, member 1
OPLAH 5-oxoprolinase (ATP-hydrolysing)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCDHGA10 protocadherin gamma subfamily A, 10
PDLIM4 PDZ and LIM domain 4
PLA2G5 phospholipase A2, group V
PLIN2 perilipin 2
PSG6 pregnancy specific beta-1-glycoprotein 6
PTGIS prostaglandin I2 (prostacyclin) synthase
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RGS12 regulator of G-protein signaling 12
RNASE4 ribonuclease, RNase A family, 4
RND1 Rho family GTPase 1
RPL35A ribosomal protein L35a
RPLP2 ribosomal protein, large, P2
S100A7 S100 calcium binding protein A7
SAA3P serum amyloid A3 pseudogene
SCN11A sodium channel, voltage gated, type XI alpha subunit
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNCAIP synuclein, alpha interacting protein
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNX1 sorting nexin 1
SYT11 synaptotagmin XI
TCF7 transcription factor 7 (T-cell specific, HMG-box)
TFDP3 transcription factor Dp family, member 3
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPMT thiopurine S-methyltransferase
TREX1 three prime repair exonuclease 1
TRIM2 tripartite motif containing 2
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TSC22D2 TSC22 domain family, member 2
ZNF358 zinc finger protein 358
ZNF76 zinc finger protein 76

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
BBS7 Bardet-Biedl syndrome 7
C11ORF30 chromosome 11 open reading frame 30
C11ORF80 chromosome 11 open reading frame 80
C19ORF73 chromosome 19 open reading frame 73
C5AR2 complement component 5a receptor 2
C6ORF47 chromosome 6 open reading frame 47
CA5BP1 carbonic anhydrase VB pseudogene 1
CBX4 chromobox homolog 4
CDK20 cyclin-dependent kinase 20
CLDN15 claudin 15
CLSTN2 calsyntenin 2
CRY2 cryptochrome circadian clock 2
CRYBG3 beta-gamma crystallin domain containing 3
CXORF56 chromosome X open reading frame 56
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DUSP8 dual specificity phosphatase 8
EFNA3 ephrin-A3
EN2 engrailed homeobox 2
EVPL envoplakin
EXD3 exonuclease 3'-5' domain containing 3
FAM120C family with sequence similarity 120C
FBXW4 F-box and WD repeat domain containing 4
FJX1 four jointed box 1 (Drosophila)
FLJ11710 uncharacterized protein FLJ11710
GAMT guanidinoacetate N-methyltransferase
GBP2 guanylate binding protein 2, interferon-inducible
GNA14 guanine nucleotide binding protein (G protein), alpha 14
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HOXD11 homeobox D11
HSPA1L heat shock 70kDa protein 1-like
IL15RA interleukin 15 receptor, alpha
IQCC IQ motif containing C
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNIP1 Kv channel interacting protein 1
KIAA0319L KIAA0319-like
LAMP3 lysosomal-associated membrane protein 3
LIG4 ligase IV, DNA, ATP-dependent
LTBP2 latent transforming growth factor beta binding protein 2
MAST3 microtubule associated serine/threonine kinase 3
MMP2 matrix metallopeptidase 2
MNS1 meiosis-specific nuclear structural 1
NBAS neuroblastoma amplified sequence
NDE1 nudE neurodevelopment protein 1
NKAIN1 Na+/K+ transporting ATPase interacting 1
NOL12 nucleolar protein 12
NOL6 nucleolar protein 6 (RNA-associated)
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5E 5'-nucleotidase, ecto (CD73)
OLFML2A olfactomedin-like 2A
ONECUT2 one cut homeobox 2
OSGIN1 oxidative stress induced growth inhibitor 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PC pyruvate carboxylase
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLXNA3 plexin A3
POLL polymerase (DNA directed), lambda
PPAN peter pan homolog (Drosophila)
PRF1 perforin 1 (pore forming protein)
PTPRU protein tyrosine phosphatase, receptor type, U
PYCRL pyrroline-5-carboxylate reductase-like
QTRT1 queuine tRNA-ribosyltransferase 1
RAB30 RAB30, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RIN1 Ras and Rab interactor 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SRD5A3 steroid 5 alpha-reductase 3
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYNC syncoilin, intermediate filament protein
TADA2A transcriptional adaptor 2A
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBC1D12 TBC1 domain family, member 12
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM121 transmembrane protein 121
TMPRSS3 transmembrane protease, serine 3
TNS2 tensin 2
UNC119 unc-119 homolog (C. elegans)
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XYLT1 xylosyltransferase I
XYLT2 xylosyltransferase II
ZNF350 zinc finger protein 350
ZNF639 zinc finger protein 639
ZNF768 zinc finger protein 768