fluoxetine-5356 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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197 genes differentially expressed following the fluoxetine-5356 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHI1 Abelson helper integration site 1
APOC1 apolipoprotein C-I
APOL2 apolipoprotein L, 2
ARC activity-regulated cytoskeleton-associated protein
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARL2BP ADP-ribosylation factor-like 2 binding protein
ATF3 activating transcription factor 3
BAIAP2 BAI1-associated protein 2
BHLHE40 basic helix-loop-helix family, member e40
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CACTIN cactin, spliceosome C complex subunit
CCNG2 cyclin G2
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CES3 carboxylesterase 3
CHKB choline kinase beta
CHPF2 chondroitin polymerizing factor 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
EGR1 early growth response 1
EGR3 early growth response 3
EPB41L1 erythrocyte membrane protein band 4.1-like 1
FAM189A2 family with sequence similarity 189, member A2
FAM46C family with sequence similarity 46, member C
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FRMD4B FERM domain containing 4B
GADD45G growth arrest and DNA-damage-inducible, gamma
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
HEG1 heart development protein with EGF-like domains 1
HIST1H2BJ histone cluster 1, H2bj
HRK harakiri, BCL2 interacting protein
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
INSR insulin receptor
JUN jun proto-oncogene
JUND jun D proto-oncogene
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KDM5A lysine (K)-specific demethylase 5A
KLF2 Kruppel-like factor 2
KLF3 Kruppel-like factor 3 (basic)
KLF6 Kruppel-like factor 6
LAMA3 laminin, alpha 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPIN1 lipin 1
LRRC61 leucine rich repeat containing 61
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP25 matrix metallopeptidase 25
MT1F metallothionein 1F
MVD mevalonate (diphospho) decarboxylase
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NF2 neurofibromin 2 (merlin)
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
OASL 2'-5'-oligoadenylate synthetase-like
PAX5 paired box 5
PCNX pecanex homolog (Drosophila)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPP6R2 protein phosphatase 6, regulatory subunit 2
PRR4 proline rich 4 (lacrimal)
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RAB8B RAB8B, member RAS oncogene family
RBL2 retinoblastoma-like 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SH3BP2 SH3-domain binding protein 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOCS1 suppressor of cytokine signaling 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SREBF2 sterol regulatory element binding transcription factor 2
TET3 tet methylcytosine dioxygenase 3
TLE4 transducin-like enhancer of split 4
TMEM104 transmembrane protein 104
TMEM80 transmembrane protein 80
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM2 tripartite motif containing 2
TSKU tsukushi, small leucine rich proteoglycan
USB1 U6 snRNA biogenesis 1
ZBTB17 zinc finger and BTB domain containing 17
ZC3H12A zinc finger CCCH-type containing 12A
ZNF16 zinc finger protein 16
ZNF750 zinc finger protein 750

decreased expression

Symbol Name
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACAD8 acyl-CoA dehydrogenase family, member 8
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADGRG2 adhesion G protein-coupled receptor G2
ADRA2C adrenoceptor alpha 2C
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
C16ORF59 chromosome 16 open reading frame 59
C17ORF70 chromosome 17 open reading frame 70
C1ORF56 chromosome 1 open reading frame 56
C5ORF45 chromosome 5 open reading frame 45
CA11 carbonic anhydrase XI
CAPN15 calpain 15
CCP110 centriolar coiled coil protein 110kDa
CISH cytokine inducible SH2-containing protein
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DENND4A DENN/MADD domain containing 4A
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
EFNA3 ephrin-A3
ELP4 elongator acetyltransferase complex subunit 4
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FAM222B family with sequence similarity 222, member B
FASTKD5 FAST kinase domains 5
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FKTN fukutin
GDAP1 ganglioside induced differentiation associated protein 1
GLI3 GLI family zinc finger 3
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
HAUS6 HAUS augmin-like complex, subunit 6
HIST1H1D histone cluster 1, H1d
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
KDM5C lysine (K)-specific demethylase 5C
KIAA1551 KIAA1551
KIFC1 kinesin family member C1
KRBOX4 KRAB box domain containing 4
KRCC1 lysine-rich coiled-coil 1
LIG4 ligase IV, DNA, ATP-dependent
LMNB1 lamin B1
LNPEP leucyl/cystinyl aminopeptidase
LOC730101 uncharacterized LOC730101
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRRC8E leucine rich repeat containing 8 family, member E
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MEFV Mediterranean fever
MPI mannose phosphate isomerase
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MVP major vault protein
NPM3 nucleophosmin/nucleoplasmin 3
NUBPL nucleotide binding protein-like
ORC2 origin recognition complex, subunit 2
PACS1 phosphofurin acidic cluster sorting protein 1
PARPBP PARP1 binding protein
PCSK7 proprotein convertase subtilisin/kexin type 7
PLXNA3 plexin A3
PRICKLE3 prickle homolog 3 (Drosophila)
PTDSS2 phosphatidylserine synthase 2
PTK6 protein tyrosine kinase 6
RABL6 RAB, member RAS oncogene family-like 6
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM42 RNA binding motif protein 42
RIBC2 RIB43A domain with coiled-coils 2
RNF121 ring finger protein 121
RNF2 ring finger protein 2
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SEH1L SEH1-like (S. cerevisiae)
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A6 solute carrier family 16, member 6
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC46A3 solute carrier family 46, member 3
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SOBP sine oculis binding protein homolog (Drosophila)
SUGP1 SURP and G patch domain containing 1
SYCP2 synaptonemal complex protein 2
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMEM38B transmembrane protein 38B
TNNT1 troponin T type 1 (skeletal, slow)
TPRA1 transmembrane protein, adipocyte asscociated 1
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TUBA3C tubulin, alpha 3c
VAV1 vav 1 guanine nucleotide exchange factor
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
WDR76 WD repeat domain 76
XK X-linked Kx blood group
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF227 zinc finger protein 227
ZNF273 zinc finger protein 273
ZNF365 zinc finger protein 365
ZNF573 zinc finger protein 573
ZNF586 zinc finger protein 586
ZNF692 zinc finger protein 692
ZNF701 zinc finger protein 701
ZNF83 zinc finger protein 83