fipexide-3176 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the fipexide-3176 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSL4 acyl-CoA synthetase long-chain family member 4
AKAP8L A kinase (PRKA) anchor protein 8-like
ANO2 anoctamin 2, calcium activated chloride channel
ARID1A AT rich interactive domain 1A (SWI-like)
ASPN asporin
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
AURKC aurora kinase C
CCDC28B coiled-coil domain containing 28B
CCL22 chemokine (C-C motif) ligand 22
CCRL2 chemokine (C-C motif) receptor-like 2
CD22 CD22 molecule
CD70 CD70 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CFAP45 cilia and flagella associated protein 45
CLDN11 claudin 11
CRHR2 corticotropin releasing hormone receptor 2
CSDC2 cold shock domain containing C2, RNA binding
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
DCBLD2 discoidin, CUB and LCCL domain containing 2
DGKI diacylglycerol kinase, iota
DKFZP434L187 uncharacterized LOC26082
DNAH7 dynein, axonemal, heavy chain 7
DOK5 docking protein 5
EDNRB endothelin receptor type B
EGF epidermal growth factor
ENOX2 ecto-NOX disulfide-thiol exchanger 2
EPB41 erythrocyte membrane protein band 4.1
FGF9 fibroblast growth factor 9
FMO1 flavin containing monooxygenase 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GREM2 gremlin 2, DAN family BMP antagonist
HAMP hepcidin antimicrobial peptide
HAS2 hyaluronan synthase 2
HEPH hephaestin
HIST1H3C histone cluster 1, H3c
HOXA10 homeobox A10
HPCA hippocalcin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGKV4-1 immunoglobulin kappa variable 4-1
INO80D INO80 complex subunit D
INSL5 insulin-like 5
IQCA1 IQ motif containing with AAA domain 1
IQCC IQ motif containing C
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KIAA0040 KIAA0040
KRT14 keratin 14, type I
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LUZP4 leucine zipper protein 4
LY86 lymphocyte antigen 86
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MDFI MyoD family inhibitor
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MYO3A myosin IIIA
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
MYOZ2 myozenin 2
NEURL1 neuralized E3 ubiquitin protein ligase 1
NEUROG1 neurogenin 1
NOVA2 neuro-oncological ventral antigen 2
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
PAX7 paired box 7
PDLIM5 PDZ and LIM domain 5
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLEKHS1 pleckstrin homology domain containing, family S member 1
PLG plasminogen
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PSD4 pleckstrin and Sec7 domain containing 4
RBBP4 retinoblastoma binding protein 4
RPL10 ribosomal protein L10
RRH retinal pigment epithelium-derived rhodopsin homolog
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SEZ6L seizure related 6 homolog (mouse)-like
SGK2 serum/glucocorticoid regulated kinase 2
SIM2 single-minded family bHLH transcription factor 2
SIRPB1 signal-regulatory protein beta 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SMC1A structural maintenance of chromosomes 1A
SOX15 SRY (sex determining region Y)-box 15
SP100 SP100 nuclear antigen
SPTBN2 spectrin, beta, non-erythrocytic 2
SRPK2 SRSF protein kinase 2
SSTR5 somatostatin receptor 5
STARD8 StAR-related lipid transfer (START) domain containing 8
SYN2 synapsin II
TGM2 transglutaminase 2
TRDMT1 tRNA aspartic acid methyltransferase 1
TTLL5 tubulin tyrosine ligase-like family member 5
UBE2B ubiquitin-conjugating enzyme E2B
USP29 ubiquitin specific peptidase 29
ZBP1 Z-DNA binding protein 1
ZNF695 zinc finger protein 695

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AKAP12 A kinase (PRKA) anchor protein 12
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ALS2CL ALS2 C-terminal like
ANXA2P3 annexin A2 pseudogene 3
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
C6ORF47 chromosome 6 open reading frame 47
CAPRIN2 caprin family member 2
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCNK cyclin K
CENPO centromere protein O
CHST10 carbohydrate sulfotransferase 10
COL4A5 collagen, type IV, alpha 5
CPSF7 cleavage and polyadenylation specific factor 7, 59kDa
CPTP ceramide-1-phosphate transfer protein
CTC1 CTS telomere maintenance complex component 1
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DEAF1 DEAF1 transcription factor
DYSF dysferlin
ECSIT ECSIT signalling integrator
ENO2 enolase 2 (gamma, neuronal)
FBXO31 F-box protein 31
FLRT3 fibronectin leucine rich transmembrane protein 3
FLT4 fms-related tyrosine kinase 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GALK1 galactokinase 1
GBP2 guanylate binding protein 2, interferon-inducible
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GUSBP3 glucuronidase, beta pseudogene 3
HIRA histone cell cycle regulator
HIST1H1B histone cluster 1, H1b
HIST1H2AL histone cluster 1, H2al
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IFI35 interferon-induced protein 35
IKZF5 IKAROS family zinc finger 5 (Pegasus)
ITPKB inositol-trisphosphate 3-kinase B
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDM8 lysine (K)-specific demethylase 8
KIF13A kinesin family member 13A
KIFAP3 kinesin-associated protein 3
KRT13 keratin 13, type I
LDHB lactate dehydrogenase B
LIN7A lin-7 homolog A (C. elegans)
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LYZ lysozyme
MAP7D1 MAP7 domain containing 1
MBOAT2 membrane bound O-acyltransferase domain containing 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MPO myeloperoxidase
MUC3A mucin 3A, cell surface associated
MYL5 myosin, light chain 5, regulatory
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
OLFML3 olfactomedin-like 3
PADI2 peptidyl arginine deiminase, type II
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLXNA3 plexin A3
PSKH1 protein serine kinase H1
RAB32 RAB32, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RNF121 ring finger protein 121
RNF19B ring finger protein 19B
RNF39 ring finger protein 39
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC46A3 solute carrier family 46, member 3
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SOX3 SRY (sex determining region Y)-box 3
SPAG4 sperm associated antigen 4
SPINK4 serine peptidase inhibitor, Kazal type 4
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SRGN serglycin
STX1A syntaxin 1A (brain)
TEAD3 TEA domain family member 3
TESC tescalcin
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TKFC triokinase/FMN cyclase
TMUB2 transmembrane and ubiquitin-like domain containing 2
UBXN6 UBX domain protein 6
UNC119 unc-119 homolog (C. elegans)
URGCP upregulator of cell proliferation
USP27X ubiquitin specific peptidase 27, X-linked
ZC3H3 zinc finger CCCH-type containing 3
ZNF324 zinc finger protein 324
ZNF350 zinc finger protein 350
ZNF696 zinc finger protein 696