fibrinogen complex Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds. (Gene Ontology, GO_0005577)
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366 proteins co-occuring with the fibrinogen complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 4.46246
F2 coagulation factor II (thrombin) 4.41595
F3 coagulation factor III (thromboplastin, tissue factor) 4.08932
PLG plasminogen 3.90008
CRP C-reactive protein, pentraxin-related 3.81671
PLAT plasminogen activator, tissue 3.51495
VWF von Willebrand factor 3.38074
F7 coagulation factor VII (serum prothrombin conversion accelerator) 3.29257
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 3.16959
ALB albumin 3.13338
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 3.03788
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.84716
F5 coagulation factor V (proaccelerin, labile factor) 2.81803
F8 coagulation factor VIII, procoagulant component 2.76883
PROS1 protein S (alpha) 2.59442
FBL fibrillarin 2.49248
FN1 fibronectin 1 2.4674
HP haptoglobin 2.40753
HPR haptoglobin-related protein 2.37309
IL6 interleukin 6 2.28925
THBD thrombomodulin 2.19481
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 2.19333
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.14642
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 2.10711
FGB fibrinogen beta chain 2.09327
FBLL1 fibrillarin-like 1 2.04304
F12 coagulation factor XII (Hageman factor) 2.03506
FGG fibrinogen gamma chain 1.99905
SEBOX SEBOX homeobox 1.96427
F9 coagulation factor IX 1.92925
FGA fibrinogen alpha chain 1.92229
PF4 platelet factor 4 1.88417
INS insulin 1.79177
CPB2 carboxypeptidase B2 (plasma) 1.75788
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 1.68726
CP ceruloplasmin (ferroxidase) 1.66901
APOB apolipoprotein B 1.64434
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.64434
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 1.63896
APOA1 apolipoprotein A-I 1.62
ICAM1 intercellular adhesion molecule 1 1.61647
CD79A CD79a molecule, immunoglobulin-associated alpha 1.57302
TF transferrin 1.55594
C3 complement component 3 1.50453
FDPS farnesyl diphosphate synthase 1.5017
F2R coagulation factor II (thrombin) receptor 1.48305
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 1.45364
TTR transthyretin 1.45307
F10 coagulation factor X 1.44064
HRG histidine-rich glycoprotein 1.42261
ASRGL1 asparaginase like 1 1.41811
KNG1 kininogen 1 1.40914
PLAU plasminogen activator, urokinase 1.39517
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.37796
TNF tumor necrosis factor 1.31789
F13A1 coagulation factor XIII, A1 polypeptide 1.29371
GPX2 glutathione peroxidase 2 1.28729
SELE selectin E 1.27983
CSN1S1 casein alpha s1 1.24393
COG2 component of oligomeric golgi complex 2 1.22828
LPA lipoprotein, Lp(a) 1.21169
FCN1 ficolin (collagen/fibrinogen domain containing) 1 1.20756
FCN3 ficolin (collagen/fibrinogen domain containing) 3 1.2055
ACE angiotensin I converting enzyme 1.19828
LYZ lysozyme 1.16953
KLKB1 kallikrein B, plasma (Fletcher factor) 1 1.1644
VCAM1 vascular cell adhesion molecule 1 1.15364
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.12858
GP1BA glycoprotein Ib (platelet), alpha polypeptide 1.09594
COX5A cytochrome c oxidase subunit Va 1.09594
SAA1 serum amyloid A1 1.07359
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.05438
ELANE elastase, neutrophil expressed 1.03729
CD40LG CD40 ligand 1.03378
FTH1 ferritin, heavy polypeptide 1 1.03228
FTL ferritin, light polypeptide 1.03078
LEP leptin 1.03029
POU2F3 POU class 2 homeobox 3 0.989759
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.987806
HPX hemopexin 0.970814
IL1B interleukin 1, beta 0.966474
GGT1 gamma-glutamyltransferase 1 0.959748
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.956874
ALPPL2 alkaline phosphatase, placental-like 2 0.950665
ALPL alkaline phosphatase, liver/bone/kidney 0.950189
ALPP alkaline phosphatase, placental 0.949713
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.93596
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.933601
RRBP1 ribosome binding protein 1 0.922791
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 0.919514
FGL2 fibrinogen-like 2 0.911113
APOE apolipoprotein E 0.895794
MASP2 mannan-binding lectin serine peptidase 2 0.892556
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.892093
CST3 cystatin C 0.890245
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.875028
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.874567
CD63 CD63 molecule 0.874567
TNC tenascin C 0.870885
AFP alpha-fetoprotein 0.869505
AMBP alpha-1-microglobulin/bikunin precursor 0.863988
SUMF1 sulfatase modifying factor 1 0.863068
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.854798
CCL2 chemokine (C-C motif) ligand 2 0.851583
SHBG sex hormone-binding globulin 0.851124
FGL1 fibrinogen-like 1 0.838269
GC group-specific component (vitamin D binding protein) 0.834597
APOH apolipoprotein H (beta-2-glycoprotein I) 0.825418
SYK spleen tyrosine kinase 0.823582
THPO thrombopoietin 0.813946
GP6 glycoprotein VI (platelet) 0.787817
MPO myeloperoxidase 0.777298
F13B coagulation factor XIII, B polypeptide 0.776384
CXCL8 chemokine (C-X-C motif) ligand 8 0.771363
ANGPTL4 angiopoietin-like 4 0.762707
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.752716
C1S complement component 1, s subcomponent 0.746833
B2M beta-2-microglobulin 0.73018
NAAA N-acylethanolamine acid amidase 0.71857
MMP9 matrix metallopeptidase 9 0.711022
AHSG alpha-2-HS-glycoprotein 0.709251
MB myoglobin 0.707039
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 0.703949
SAA2 serum amyloid A2 0.694709
APOA4 apolipoprotein A-IV 0.690764
PROCR protein C receptor, endothelial 0.683335
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.671159
C5AR1 complement component 5a receptor 1 0.660345
GP9 glycoprotein IX (platelet) 0.656895
RETN resistin 0.656464
TNXB tenascin XB 0.65001
TNXA tenascin XA (pseudogene) 0.65001
MBL2 mannose-binding lectin (protein C) 2, soluble 0.639289
LTF lactotransferrin 0.638005
HBA2 hemoglobin, alpha 2 0.630318
THBS1 thrombospondin 1 0.626057
C4A complement component 4A (Rodgers blood group) 0.621804
MPI mannose phosphate isomerase 0.620954
LBP lipopolysaccharide binding protein 0.615013
CTSG cathepsin G 0.613742
CPA6 carboxypeptidase A6 0.611201
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.609086
FIBCD1 fibrinogen C domain containing 1 0.603596
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.594332
IGF1 insulin-like growth factor 1 (somatomedin C) 0.592232
REN renin 0.591812
APOA2 apolipoprotein A-II 0.585942
PLA2G1B phospholipase A2, group IB (pancreas) 0.584686
GPR176 G protein-coupled receptor 176 0.582176
ITGAV integrin, alpha V 0.577581
ANXA5 annexin A5 0.572578
CPB1 carboxypeptidase B1 (tissue) 0.570496
MMRN1 multimerin 1 0.561772
IL6R interleukin 6 receptor 0.560114
PTH parathyroid hormone 0.558871
VEGFA vascular endothelial growth factor A 0.558871
A2M alpha-2-macroglobulin 0.547297
PRTN3 proteinase 3 0.54606
SOD2 superoxide dismutase 2, mitochondrial 0.545648
PTK2 protein tyrosine kinase 2 0.544
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.542352
CSN3 casein kappa 0.537416
HBA1 hemoglobin, alpha 1 0.53413
IL1RN interleukin 1 receptor antagonist 0.528798
CD36 CD36 molecule (thrombospondin receptor) 0.525522
KIAA0101 KIAA0101 0.523885
PHF12 PHD finger protein 12 0.521432
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.521023
CTRL chymotrypsin-like 0.512862
APCS amyloid P component, serum 0.511233
RAP1B RAP1B, member of RAS oncogene family 0.509604
CADM1 cell adhesion molecule 1 0.509197
ZFYVE9 zinc finger, FYVE domain containing 9 0.50757
FGF2 fibroblast growth factor 2 (basic) 0.505944
RNASE3 ribonuclease, RNase A family, 3 0.50107
CAT catalase 0.496205
SPP1 secreted phosphoprotein 1 0.490539
CTSB cathepsin B 0.487307
ITGB8 integrin, beta 8 0.486096
SELPLG selectin P ligand 0.485693
GGT2 gamma-glutamyltransferase 2 0.48287
TSPO translocator protein (18kDa) 0.479647
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.47844
ANGPTL1 angiopoietin-like 1 0.478038
ANGPTL3 angiopoietin-like 3 0.470005
IL18 interleukin 18 0.469604
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 0.458404
ANGPTL2 angiopoietin-like 2 0.457606
ITGB7 integrin, beta 7 0.457606
MGAM maltase-glucoamylase 0.457208
ITGB6 integrin, beta 6 0.456809
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.453621
GPX1 glutathione peroxidase 1 0.444482
CD9 CD9 molecule 0.443689
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.43696
SELL selectin L 0.434196
PON1 paraoxonase 1 0.433801
TNR tenascin R 0.432618
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.432618
PNMA1 paraneoplastic Ma antigen 1 0.432224
ANGPTL5 angiopoietin-like 5 0.430253
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.427891
APOC3 apolipoprotein C-III 0.427104
CD5L CD5 molecule-like 0.424353
GCG glucagon 0.42396
CFP complement factor properdin 0.42396
F11 coagulation factor XI 0.423567
AAAS achalasia, adrenocortical insufficiency, alacrimia 0.421997
LRG1 leucine-rich alpha-2-glycoprotein 1 0.416902
GSN gelsolin 0.415337
MMP2 matrix metallopeptidase 2 0.414946
DLL1 delta-like 1 (Drosophila) 0.41221
HABP2 hyaluronan binding protein 2 0.405193
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.400916
CFB complement factor B 0.39626
TGM4 transglutaminase 4 0.388523
MEFV Mediterranean fever 0.386208
TGFB1 transforming growth factor, beta 1 0.38428
PGF placental growth factor 0.383509
TNNT2 troponin T type 2 (cardiac) 0.380814
TBXAS1 thromboxane A synthase 1 (platelet) 0.380045
PATE1 prostate and testis expressed 1 0.378122
LPO lactoperoxidase 0.375818
ITLN1 intelectin 1 (galactofuranose binding) 0.374666
CETP cholesteryl ester transfer protein, plasma 0.373899
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.372366
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 0.372366
SFTPD surfactant protein D 0.371599
ITGB4 integrin, beta 4 0.362804
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.36204
IL1A interleukin 1, alpha 0.359752
POMC proopiomelanocortin 0.357467
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.357086
GPX5 glutathione peroxidase 5 0.355944
PRSS21 protease, serine, 21 (testisin) 0.354802
FGR FGR proto-oncogene, Src family tyrosine kinase 0.352901
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.350243
GPX4 glutathione peroxidase 4 0.350243
P2RY12 purinergic receptor P2Y, G-protein coupled, 12 0.347587
BCHE butyrylcholinesterase 0.343799
VEPH1 ventricular zone expressed PH domain-containing 1 0.342664
CYGB cytoglobin 0.342285
IL11 interleukin 11 0.342285
NOS3 nitric oxide synthase 3 (endothelial cell) 0.341529
FBN1 fibrillin 1 0.339261
PADI4 peptidyl arginine deiminase, type IV 0.338128
VASP vasodilator-stimulated phosphoprotein 0.336996
NAGS N-acetylglutamate synthase 0.336619
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 0.332848
CD4 CD4 molecule 0.330213
RBP4 retinol binding protein 4, plasma 0.330213
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 0.326453
TBXA2R thromboxane A2 receptor 0.325327
ZNF324 zinc finger protein 324 0.323075
SPINK9 serine peptidase inhibitor, Kazal type 9 0.323075
TRBC2 T cell receptor beta constant 2 0.323075
SLC44A3 solute carrier family 44, member 3 0.323075
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 0.319328
ETV3 ets variant 3 0.315586
TLR4 toll-like receptor 4 0.314465
ICAM2 intercellular adhesion molecule 2 0.311851
C1R complement component 1, r subcomponent 0.310732
CBS cystathionine-beta-synthase 0.310732
TIMP1 TIMP metallopeptidase inhibitor 1 0.30924
ZNF483 zinc finger protein 483 0.305515
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.304399
ESAM endothelial cell adhesion molecule 0.303655
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.302912
KLK14 kallikrein-related peptidase 14 0.302912
CD34 CD34 molecule 0.300311
GPX3 glutathione peroxidase 3 0.29994
IL10 interleukin 10 0.291787
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.283295
CFH complement factor H 0.281453
LYN LYN proto-oncogene, Src family tyrosine kinase 0.278509
NAMPT nicotinamide phosphoribosyltransferase 0.277406
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.275569
CLEC3B C-type lectin domain family 3, member B 0.274835
HNF1A HNF1 homeobox A 0.273
SPARCL1 SPARC-like 1 (hevin) 0.270068
A1BG alpha-1-B glycoprotein 0.268969
ERI2 ERI1 exoribonuclease family member 2 0.267505
IGLV5-52 immunoglobulin lambda variable 5-52 0.267505
ZCCHC16 zinc finger, CCHC domain containing 16 0.262755
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.260931
GRHL1 grainyhead-like 1 (Drosophila) 0.257652
PZP pregnancy-zone protein 0.257289
MFAP4 microfibrillar-associated protein 4 0.255107
NID1 nidogen 1 0.25438
PRSS1 protease, serine, 1 (trypsin 1) 0.253291
LCN2 lipocalin 2 0.252927
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.249302
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.248578
TRIM37 tripartite motif containing 37 0.247854
TLN1 talin 1 0.247854
TG thyroglobulin 0.247854
P4HB prolyl 4-hydroxylase, beta polypeptide 0.24713
IL4I1 interleukin 4 induced 1 0.243519
LATS1 large tumor suppressor kinase 1 0.243158
CIB1 calcium and integrin binding 1 (calmyrin) 0.242797
NAT9 N-acetyltransferase 9 (GCN5-related, putative) 0.242437
ENO1 enolase 1, (alpha) 0.242076
CLU clusterin 0.237042
FBLN1 fibulin 1 0.235249
BMP2K BMP2 inducible kinase 0.234891
APP amyloid beta (A4) precursor protein 0.233459
S100A12 S100 calcium binding protein A12 0.232744
AFM afamin 0.227752
PPARA peroxisome proliferator-activated receptor alpha 0.226686
LECT2 leukocyte cell-derived chemotaxin 2 0.225267
LPL lipoprotein lipase 0.22385
EDN1 endothelin 1 0.222083
RFC2 replication factor C (activator 1) 2, 40kDa 0.221025
CTSC cathepsin C 0.21681
SCARB1 scavenger receptor class B, member 1 0.216111
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 0.216111
PLAUR plasminogen activator, urokinase receptor 0.215761
NONO non-POU domain containing, octamer-binding 0.214366
NPPB natriuretic peptide B 0.208137
CD47 CD47 molecule 0.207108
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.206766
FLG filaggrin 0.206423
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.206082
KLK3 kallikrein-related peptidase 3 0.204378
FGF1 fibroblast growth factor 1 (acidic) 0.200999
SHC4 SHC (Src homology 2 domain containing) family, member 4 0.196999
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.195353
PLEK pleckstrin 0.193719
APOC1 apolipoprotein C-I 0.191135
VCL vinculin 0.190814
SCARB2 scavenger receptor class B, member 2 0.18516
OSM oncostatin M 0.18516
ANGPT1 angiopoietin 1 0.184241
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.181823
ESR1 estrogen receptor 1 0.18093
ANXA2 annexin A2 0.177724
CDH5 cadherin 5, type 2 (vascular endothelium) 0.177724
VSIG4 V-set and immunoglobulin domain containing 4 0.177439
VAV1 vav 1 guanine nucleotide exchange factor 0.177154
KLK1 kallikrein 1 0.176024
LDLR low density lipoprotein receptor 0.175466
BGLAP bone gamma-carboxyglutamate (gla) protein 0.175188
GAS6 growth arrest-specific 6 0.175188
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 0.173543
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 0.173543
TSKU tsukushi, small leucine rich proteoglycan 0.173003
FETUB fetuin B 0.171937
BHLHE22 basic helix-loop-helix family, member e22 0.171149
NFIB nuclear factor I/B 0.170888
MMP26 matrix metallopeptidase 26 0.170371
PPARG peroxisome proliferator-activated receptor gamma 0.169859
CFI complement factor I 0.16935
GP5 glycoprotein V (platelet) 0.168847
FERMT3 fermitin family member 3 0.166643
NFIA nuclear factor I/A 0.166167
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.165697
TNNI3 troponin I type 3 (cardiac) 0.165231
PRR4 proline rich 4 (lacrimal) 0.165231
IL2 interleukin 2 0.165
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.163641
CFHR1 complement factor H-related 1 0.161275
SPINK1 serine peptidase inhibitor, Kazal type 1 0.159268
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.158882
OR10K1 olfactory receptor, family 10, subfamily K, member 1 0.15776
KRT10 keratin 10, type I 0.156688
S100A8 S100 calcium binding protein A8 0.156513