felodipine-3295 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the felodipine-3295 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ATF3 activating transcription factor 3
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
C11ORF16 chromosome 11 open reading frame 16
C17ORF53 chromosome 17 open reading frame 53
CA5B carbonic anhydrase VB, mitochondrial
CCL5 chemokine (C-C motif) ligand 5
CD83 CD83 molecule
CDK19 cyclin-dependent kinase 19
CGA glycoprotein hormones, alpha polypeptide
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DLX2 distal-less homeobox 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNASE1 deoxyribonuclease I
DSC2 desmocollin 2
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR4 early growth response 4
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GEM GTP binding protein overexpressed in skeletal muscle
GRB7 growth factor receptor-bound protein 7
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HFE hemochromatosis
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H2AE histone cluster 1, H2ae
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BN histone cluster 1, H2bn
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
ICOSLG inducible T-cell co-stimulator ligand
IER2 immediate early response 2
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INHBE inhibin, beta E
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K5 mitogen-activated protein kinase kinase 5
MTSS1L metastasis suppressor 1-like
NCKIPSD NCK interacting protein with SH3 domain
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OASL 2'-5'-oligoadenylate synthetase-like
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAU plasminogen activator, urokinase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RND1 Rho family GTPase 1
RYR1 ryanodine receptor 1 (skeletal)
SCN10A sodium channel, voltage gated, type X alpha subunit
SEC14L5 SEC14-like 5 (S. cerevisiae)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPRY4 sprouty homolog 4 (Drosophila)
SQSTM1 sequestosome 1
SRCAP Snf2-related CREBBP activator protein
STK24 serine/threonine kinase 24
TLR2 toll-like receptor 2
TMPRSS4 transmembrane protease, serine 4
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPMT thiopurine S-methyltransferase
TRIB1 tribbles pseudokinase 1
USP2 ubiquitin specific peptidase 2
ZFP36 ZFP36 ring finger protein
ZMIZ2 zinc finger, MIZ-type containing 2

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ANKFY1 ankyrin repeat and FYVE domain containing 1
APOC1 apolipoprotein C-I
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARL15 ADP-ribosylation factor-like 15
ARRB1 arrestin, beta 1
ASPHD1 aspartate beta-hydroxylase domain containing 1
BBS7 Bardet-Biedl syndrome 7
BMP4 bone morphogenetic protein 4
C14ORF79 chromosome 14 open reading frame 79
C1ORF105 chromosome 1 open reading frame 105
C3 complement component 3
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALCOCO1 calcium binding and coiled-coil domain 1
CCDC121 coiled-coil domain containing 121
CCDC47 coiled-coil domain containing 47
CENPO centromere protein O
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CLCF1 cardiotrophin-like cytokine factor 1
CLSPN claspin
CORO7 coronin 7
CRYBB2P1 crystallin, beta B2 pseudogene 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAAH fatty acid amide hydrolase
FAM111A family with sequence similarity 111, member A
FAM160B2 family with sequence similarity 160, member B2
FAM184A family with sequence similarity 184, member A
FLCN folliculin
GADD45G growth arrest and DNA-damage-inducible, gamma
GDAP1 ganglioside induced differentiation associated protein 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR143 G protein-coupled receptor 143
GRTP1 growth hormone regulated TBC protein 1
GSTA4 glutathione S-transferase alpha 4
HPN hepsin
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
IFT140 intraflagellar transport 140
IPO8 importin 8
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
KCNK5 potassium channel, two pore domain subfamily K, member 5
KREMEN2 kringle containing transmembrane protein 2
LAMB1 laminin, beta 1
LHX6 LIM homeobox 6
LIN7B lin-7 homolog B (C. elegans)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LY6D lymphocyte antigen 6 complex, locus D
LYRM9 LYR motif containing 9
MEFV Mediterranean fever
MOCS3 molybdenum cofactor synthesis 3
MRPL44 mitochondrial ribosomal protein L44
MSMB microseminoprotein, beta-
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NKX3-2 NK3 homeobox 2
NLRX1 NLR family member X1
NME6 NME/NM23 nucleoside diphosphate kinase 6
NOL10 nucleolar protein 10
NPY5R neuropeptide Y receptor Y5
NT5E 5'-nucleotidase, ecto (CD73)
NUDT2 nudix (nucleoside diphosphate linked moiety X)-type motif 2
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PCBP4 poly(rC) binding protein 4
PCDHB13 protocadherin beta 13
PCDHGB5 protocadherin gamma subfamily B, 5
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G3 phospholipase A2, group III
PLD2 phospholipase D2
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RBM41 RNA binding motif protein 41
RNF121 ring finger protein 121
RNF122 ring finger protein 122
RNF2 ring finger protein 2
RPL23AP32 ribosomal protein L23a pseudogene 32
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SH2D4A SH2 domain containing 4A
SH3GL1 SH3-domain GRB2-like 1
SP1 Sp1 transcription factor
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TDRKH tudor and KH domain containing
TEP1 telomerase-associated protein 1
TMC7 transmembrane channel-like 7
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TRAPPC13 trafficking protein particle complex 13
UBQLN4 ubiquilin 4
USB1 U6 snRNA biogenesis 1
XYLT2 xylosyltransferase II
ZBTB6 zinc finger and BTB domain containing 6
ZNF134 zinc finger protein 134
ZNF137P zinc finger protein 137, pseudogene
ZNF204P zinc finger protein 204, pseudogene
ZNF219 zinc finger protein 219
ZNF350 zinc finger protein 350
ZNF480 zinc finger protein 480