failure of primitive streak formation Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description inability to form the epiblast ridge from which arises the germ layers of the embryo (Mammalian Phenotype Ontology, MP_0001693)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0001693
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Genes

32 gene mutations causing the failure of primitive streak formation phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
ACVR1B activin A receptor, type IB
BMP4 bone morphogenetic protein 4
BMPR1A bone morphogenetic protein receptor, type IA
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BPTF bromodomain PHD finger transcription factor
BRCA1 breast cancer 1, early onset
CHD8 chromodomain helicase DNA binding protein 8
EXT1 exostosin glycosyltransferase 1
EXT2 exostosin glycosyltransferase 2
FGFR1 fibroblast growth factor receptor 1
FOXD3 forkhead box D3
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
MACF1 microtubule-actin crosslinking factor 1
MESDC2 mesoderm development candidate 2
MYL1 myosin, light chain 1, alkali; skeletal, fast
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NFE2L1 nuclear factor, erythroid 2-like 1
NODAL nodal growth differentiation factor
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PKNOX1 PBX/knotted 1 homeobox 1
PNN pinin, desmosome associated protein
PRICKLE1 prickle homolog 1 (Drosophila)
SMAD2 SMAD family member 2
SMAD4 SMAD family member 4
SRF serum response factor (c-fos serum response element-binding transcription factor)
TDGF1 teratocarcinoma-derived growth factor 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TRIM33 tripartite motif containing 33
TSG101 tumor susceptibility 101
TXNRD1 thioredoxin reductase 1
WLS wntless Wnt ligand secretion mediator
WNT3 wingless-type MMTV integration site family, member 3