excitatory synapse Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. (Gene Ontology, GO_0060076)
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Genes

272 proteins co-occuring with the excitatory synapse cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.88072
NLGN1 neuroligin 1 1.68726
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.64852
SHANK3 SH3 and multiple ankyrin repeat domains 3 1.55424
GRIA2 glutamate receptor, ionotropic, AMPA 2 1.51186
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 1.48645
NLGN2 neuroligin 2 1.435
GRM1 glutamate receptor, metabotropic 1 1.39684
SHANK2 SH3 and multiple ankyrin repeat domains 2 1.38627
PICK1 protein interacting with PRKCA 1 1.38073
GPHN gephyrin 1.37464
LRRTM2 leucine rich repeat transmembrane neuronal 2 1.37023
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.34828
DLG3 discs, large homolog 3 (Drosophila) 1.34447
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 1.26868
SHANK1 SH3 and multiple ankyrin repeat domains 1 1.26815
GRM5 glutamate receptor, metabotropic 5 1.17209
BDNF brain-derived neurotrophic factor 1.17004
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 1.16901
NLGN3 neuroligin 3 1.1685
SLITRK3 SLIT and NTRK-like family, member 3 1.09187
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 1.08171
PSD pleckstrin and Sec7 domain containing 1.06144
DLG4 discs, large homolog 4 (Drosophila) 1.05236
RBM10 RNA binding motif protein 10 1.03829
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 1.03479
PVALB parvalbumin 1.02331
HOMER1 homer scaffolding protein 1 1.01883
LRRTM4 leucine rich repeat transmembrane neuronal 4 1.0035
IQSEC2 IQ motif and Sec7 domain 2 0.997595
DLG1 discs, large homolog 1 (Drosophila) 0.997595
CNR1 cannabinoid receptor 1 (brain) 0.993672
NTNG1 netrin G1 0.977589
LRRC4B leucine rich repeat containing 4B 0.968884
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.951619
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.950189
CBLN1 cerebellin 1 precursor 0.93596
DBN1 drebrin 1 0.929833
NLGN4X neuroligin 4, X-linked 0.924666
SYNGAP1 synaptic Ras GTPase activating protein 1 0.90739
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.898572
LRRTM1 leucine rich repeat transmembrane neuronal 1 0.895794
KIRREL2 kin of IRRE like 2 (Drosophila) 0.893943
LRRC4C leucine rich repeat containing 4C 0.893018
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 0.891631
TMEM2 transmembrane protein 2 0.888397
GRIP1 glutamate receptor interacting protein 1 0.870885
CBLN2 cerebellin 2 precursor 0.870426
ZC4H2 zinc finger, C4H2 domain containing 0.869046
SYT15 synaptotagmin XV 0.86123
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.859852
SHISA9 shisa family member 9 0.85342
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase 0.852961
NTNG2 netrin G2 0.841941
GRIA3 glutamate receptor, ionotropic, AMPA 3 0.835515
SYP synaptophysin 0.823582
IGSF9B immunoglobulin superfamily, member 9B 0.810276
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.809817
EFNB3 ephrin-B3 0.804313
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 0.795145
EPHB2 EPH receptor B2 0.779126
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 0.765438
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.756799
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 0.756799
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.756345
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.755891
CBLN4 cerebellin 4 precursor 0.75317
NRXN1 neurexin 1 0.749546
GRM2 glutamate receptor, metabotropic 2 0.746833
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.737813
CABP1 calcium binding protein 1 0.734666
SYN1 synapsin I 0.723026
ARC activity-regulated cytoskeleton-associated protein 0.720351
PCDH20 protocadherin 20 0.707924
GRM4 glutamate receptor, metabotropic 4 0.698223
NPTX2 neuronal pentraxin II 0.693832
BSN bassoon presynaptic cytomatrix protein 0.687701
FLRT3 fibronectin leucine rich transmembrane protein 3 0.687701
NPTX1 neuronal pentraxin I 0.678108
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.675065
ERBB4 erb-b2 receptor tyrosine kinase 4 0.67246
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.668992
LRRC4 leucine rich repeat containing 4 0.66726
GSG1L GSG1-like 0.660345
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.650439
TJP1 tight junction protein 1 0.648721
ZDHHC8 zinc finger, DHHC-type containing 8 0.647433
ADGRL3 adhesion G protein-coupled receptor L3 0.646574
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.643144
CTTNBP2 cortactin binding protein 2 0.640573
TARP TCR gamma alternate reading frame protein 0.63715
LRRC7 leucine rich repeat containing 7 0.636295
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.626909
NXPH1 neurexophilin 1 0.603174
MECP2 methyl CpG binding protein 2 0.597276
GLUD2 glutamate dehydrogenase 2 0.591392
HOMER2 homer scaffolding protein 2 0.589295
KALRN kalirin, RhoGEF kinase 0.581758
CPLX2 complexin 2 0.570913
DSE dermatan sulfate epimerase 0.569248
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 0.563847
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 0.5597
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 0.557629
DACT1 dishevelled-binding antagonist of beta-catenin 1 0.557214
GUK1 guanylate kinase 1 0.555973
GPC4 glypican 4 0.552664
RAX2 retina and anterior neural fold homeobox 2 0.552251
CADM1 cell adhesion molecule 1 0.544411
CDKL5 cyclin-dependent kinase-like 5 0.537416
RELN reelin 0.533719
CPLX1 complexin 1 0.528388
FCN3 ficolin (collagen/fibrinogen domain containing) 3 0.526341
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.515716
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.514085
NEXN nexilin (F actin binding protein) 0.51164
RNF167 ring finger protein 167 0.510418
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 0.510418
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.50879
EPHB3 EPH receptor B3 0.500664
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 0.500664
CTNND2 catenin (cadherin-associated protein), delta 2 0.49742
FMR1 fragile X mental retardation 1 0.49661
OPHN1 oligophrenin 1 0.49661
RTN4RL1 reticulon 4 receptor-like 1 0.494585
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.484483
LHB luteinizing hormone beta polypeptide 0.484079
NRG1 neuregulin 1 0.480453
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 0.475625
TBKBP1 TBK1 binding protein 1 0.472813
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.472412
EPHA4 EPH receptor A4 0.469203
DGKZ diacylglycerol kinase, zeta 0.458803
SST somatostatin 0.45641
RTN4RL2 reticulon 4 receptor-like 2 0.449643
SRR serine racemase 0.443292
RIMS1 regulating synaptic membrane exocytosis 1 0.439728
HIST1H1A histone cluster 1, H1a 0.438937
ZDHHC3 zinc finger, DHHC-type containing 3 0.434985
MUSK muscle, skeletal, receptor tyrosine kinase 0.434985
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.434196
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.430647
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 0.426711
MCF2L MCF.2 cell line derived transforming sequence-like 0.425138
HCAR1 hydroxycarboxylic acid receptor 1 0.424745
HCRT hypocretin (orexin) neuropeptide precursor 0.420036
NRGN neurogranin (protein kinase C substrate, RC3) 0.419252
PCP4 Purkinje cell protein 4 0.418468
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.415728
KIF26B kinesin family member 26B 0.410259
SRCIN1 SRC kinase signaling inhibitor 1 0.404804
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.404415
OPRM1 opioid receptor, mu 1 0.404026
STRN striatin, calmodulin binding protein 0.400916
ADAM10 ADAM metallopeptidase domain 10 0.400916
MEA1 male-enhanced antigen 1 0.397035
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.394323
KIF5C kinesin family member 5C 0.392388
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.388137
CRH corticotropin releasing hormone 0.387365
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.385436
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.385436
IGSF9 immunoglobulin superfamily, member 9 0.383895
GPC6 glypican 6 0.383895
NPY neuropeptide Y 0.381584
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 0.380814
GRIK1 glutamate receptor, ionotropic, kainate 1 0.378507
POU6F2 POU class 6 homeobox 2 0.373516
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 0.371982
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.371599
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.364713
KARS lysyl-tRNA synthetase 0.354802
PCDH10 protocadherin 10 0.351762
REM2 RAS (RAD and GEM)-like GTP binding 2 0.349105
ACTN2 actinin, alpha 2 0.348725
GRIP2 glutamate receptor interacting protein 2 0.344178
MAGEE1 melanoma antigen family E1 0.343799
PLK2 polo-like kinase 2 0.338506
GRM7 glutamate receptor, metabotropic 7 0.33511
WNT8A wingless-type MMTV integration site family, member 8A 0.333602
DLG5 discs, large homolog 5 (Drosophila) 0.333602
PTPRF protein tyrosine phosphatase, receptor type, F 0.325702
CDH8 cadherin 8, type 2 0.324951
TRAPPC4 trafficking protein particle complex 4 0.324951
TIAM1 T-cell lymphoma invasion and metastasis 1 0.322325
SDC2 syndecan 2 0.320077
DRD2 dopamine receptor D2 0.319328
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.319328
NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 0.31783
GABARAP GABA(A) receptor-associated protein 0.316708
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 0.31596
GRIK4 glutamate receptor, ionotropic, kainate 4 0.315586
LZTS2 leucine zipper, putative tumor suppressor 2 0.309986
CHAT choline O-acetyltransferase 0.309986
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 0.30924
CA4 carbonic anhydrase IV 0.305888
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 0.305515
ADCY1 adenylate cyclase 1 (brain) 0.305515
SYNPO synaptopodin 0.301054
ADORA1 adenosine A1 receptor 0.294748
LIMK1 LIM domain kinase 1 0.286245
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.284769
CRHR1 corticotropin releasing hormone receptor 1 0.284401
PRG1 p53-responsive gene 1 0.283663
CTTN cortactin 0.280349
PTPRD protein tyrosine phosphatase, receptor type, D 0.277774
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.277406
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.273
CRIPT cysteine-rich PDZ-binding protein 0.271167
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.268237
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 0.268237
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.265311
PUM2 pumilio RNA-binding family member 2 0.264581
NPY2R neuropeptide Y receptor Y2 0.264215
TNR tenascin R 0.262755
LZTS1 leucine zipper, putative tumor suppressor 1 0.258381
NSF N-ethylmaleimide-sensitive factor 0.258016
RAB3A RAB3A, member RAS oncogene family 0.254743
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.253291
MYEF2 myelin expression factor 2 0.251114
CALY calcyon neuron-specific vesicular protein 0.243879
BAIAP2 BAI1-associated protein 2 0.242797
ADAM23 ADAM metallopeptidase domain 23 0.242437
NBEA neurobeachin 0.242437
NGFR nerve growth factor receptor 0.238837
CDC42 cell division cycle 42 0.231672
GRIK2 glutamate receptor, ionotropic, kainate 2 0.228819
PLXNA3 plexin A3 0.227752
ITPKA inositol-trisphosphate 3-kinase A 0.222436
VAC14 Vac14 homolog (S. cerevisiae) 0.215761
EFNA3 ephrin-A3 0.214017
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.212627
RGS12 regulator of G-protein signaling 12 0.21228
BAIAP2L1 BAI1-associated protein 2-like 1 0.21228
PTPRS protein tyrosine phosphatase, receptor type, S 0.211587
TSPAN7 tetraspanin 7 0.21124
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 0.209169
AKAP5 A kinase (PRKA) anchor protein 5 0.206423
GDF5 growth differentiation factor 5 0.206082
ADAM28 ADAM metallopeptidase domain 28 0.205399
VEZT vezatin, adherens junctions transmembrane protein 0.202009
LGI1 leucine-rich, glioma inactivated 1 0.202009
SHARPIN SHANK-associated RH domain interactor 0.197993
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.19307
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.190814
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 0.190814
TRPV3 transient receptor potential cation channel, subfamily V, member 3 0.185469
HDAC2 histone deacetylase 2 0.184853
NTM neurotrimin 0.183935
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.181524
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 0.178877
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.178299
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 0.177154
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.17687
TMOD4 tropomodulin 4 (muscle) 0.176024
NOS1 nitric oxide synthase 1 (neuronal) 0.176024
ADGRB1 adhesion G protein-coupled receptor B1 0.175745
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.174361
PLXNA4 plexin A4 0.171937
SYNE1 spectrin repeat containing, nuclear envelope 1 0.171149
PYCR1 pyrroline-5-carboxylate reductase 1 0.170371
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 0.169859
FAAH fatty acid amide hydrolase 0.169859
UBE3A ubiquitin protein ligase E3A 0.16935
SKAP2 src kinase associated phosphoprotein 2 0.167611
DNM3 dynamin 3 0.16298
ADAM22 ADAM metallopeptidase domain 22 0.16298
CNR2 cannabinoid receptor 2 (macrophage) 0.162763
CAMK2B calcium/calmodulin-dependent protein kinase II beta 0.161905
DLX1 distal-less homeobox 1 0.160254
FYN FYN proto-oncogene, Src family tyrosine kinase 0.158882
COMMD1 copper metabolism (Murr1) domain containing 1 0.157943
DVL1 dishevelled segment polarity protein 1 0.156513